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Protein
Submitted name:

Nuclear receptor subfamily 4 group A member 1

Gene

NR4A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi318 – 393Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear receptor subfamily 4 group A member 1Imported
Gene namesi
Name:NR4A1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000123358.19
HGNCiHGNC:7980 NR4A1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000123358

PTM / Processingi

Proteomic databases

EPDiF5GXF0
MaxQBiF5GXF0
PRIDEiF5GXF0

Expressioni

Gene expression databases

BgeeiENSG00000123358
ExpressionAtlasiF5GXF0 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliF5GXF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini318 – 393Nuclear receptorInterPro annotationAdd BLAST76
Domaini414 – 649NR LBDInterPro annotationAdd BLAST236

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4217 Eukaryota
ENOG410YWNC LUCA
GeneTreeiENSGT00760000118887
OMAiTDRHGLQ
OrthoDBiEOG091G0GUM
PhylomeDBiF5GXF0

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR003071 Nuc_orp_HMR_rcpt
IPR003070 Nuc_orph_rcpt
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01285 HMRNUCRECPTR
PR01284 NUCLEARECPTR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

F5GXF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSAQYKIKI LIEGLHHGQR PGPAPPRQPG SFCWALKADG IMWLAKACWS
60 70 80 90 100
IQSEMPCIQA QYGTPAPSPG PRDHLASDPL TPEFIKPTMD LASPEAAPAA
110 120 130 140 150
PTALPSFSTF MDGYTGEFDT FLYQLPGTVQ PCSSASSSAS STSSSSATSP
160 170 180 190 200
ASASFKFEDF QVYGCYPGPL SGPVDEALSS SGSDYYGSPC SAPSPSTPSF
210 220 230 240 250
QPPQLSPWDG SFGHFSPSQT YEGLRAWTEQ LPKASGPPQP PAFFSFSPPT
260 270 280 290 300
GPSPSLAQSP LKLFPSQATH QLGEGESYSM PTAFPGLAPT SPHLEGSGIL
310 320 330 340 350
DTPVTSTKAR SGAPGGSEGR CAVCGDNASC QHYGVRTCEG CKGFFKRTVQ
360 370 380 390 400
KNAKYICLAN KDCPVDKRRR NRCQFCRFQK CLAVGMVKEV VRTDSLKGRR
410 420 430 440 450
GRLPSKPKQP PDASPANLLT SLVRAHLDSG PSTAKLDYSK FQELVLPHFG
460 470 480 490 500
KEDAGDVQQF YDLLSGSLEV IRKWAEKIPG FAELSPADQD LLLESAFLEL
510 520 530 540 550
FILRLAYRSK PGEGKLIFCS GLVLHRLQCA RGFGDWIDSI LAFSRSLHSL
560 570 580 590 600
LVDVPAFACL SALVLITDRH GLQEPRRVEE LQNRIASCLK EHVAAVAGEP
610 620 630 640 650
QPASCLSRLL GKLPELRTLC TQGLQRIFYL KLEDLVPPPP IIDKIFMDTL

PF
Length:652
Mass (Da):70,451
Last modified:June 28, 2011 - v1
Checksum:iFFA44C6BD5A9BC51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025259 Genomic DNA No translation available.
RefSeqiNP_001189163.1, NM_001202234.1
UniGeneiHs.524430
Hs.670088

Genome annotation databases

EnsembliENST00000545748; ENSP00000440864; ENSG00000123358
GeneIDi3164
UCSCiuc058ofg.1 human

Similar proteinsi

Entry informationi

Entry nameiF5GXF0_HUMAN
AccessioniPrimary (citable) accession number: F5GXF0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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