UniProtKB - F5GWT4 (F5GWT4_HUMAN)
Protein
Non-specific serine/threonine protein kinase
Gene
WNK1
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
GO - Molecular functioni
- ATP binding Source: InterPro
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
Keywordsi
Molecular function | KinaseARBA annotation, Transferase |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
SignaLinki | F5GWT4 |
Names & Taxonomyi
Protein namesi | Recommended name: Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation) |
Gene namesi | Name:WNK1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14540, WNK1 |
VEuPathDBi | HostDB:ENSG00000060237.16 |
PTM / Processingi
Proteomic databases
EPDi | F5GWT4 |
MaxQBi | F5GWT4 |
PeptideAtlasi | F5GWT4 |
PRIDEi | F5GWT4 |
ProteomicsDBi | 24212 |
Expressioni
Gene expression databases
Bgeei | ENSG00000060237, Expressed in corpus callosum and 249 other tissues |
ExpressionAtlasi | F5GWT4, baseline and differential |
Genevisiblei | F5GWT4, HS |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 221 – 479 | Protein kinaseInterPro annotationAdd BLAST | 259 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 81 | DisorderedSequence analysisAdd BLAST | 81 | |
Regioni | 95 – 203 | DisorderedSequence analysisAdd BLAST | 109 | |
Regioni | 573 – 873 | DisorderedSequence analysisAdd BLAST | 301 | |
Regioni | 1210 – 1229 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1486 – 1542 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 1618 – 1700 | DisorderedSequence analysisAdd BLAST | 83 | |
Regioni | 1749 – 1821 | DisorderedSequence analysisAdd BLAST | 73 | |
Regioni | 1853 – 1948 | DisorderedSequence analysisAdd BLAST | 96 | |
Regioni | 2084 – 2105 | DisorderedSequence analysisAdd BLAST | 22 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1825 – 1845 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 17 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 49 – 65 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 101 – 115 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 152 – 168 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 573 – 589 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 590 – 629 | PolarSequence analysisAdd BLAST | 40 | |
Compositional biasi | 636 – 798 | PolarSequence analysisAdd BLAST | 163 | |
Compositional biasi | 806 – 845 | PolarSequence analysisAdd BLAST | 40 | |
Compositional biasi | 849 – 869 | BasicSequence analysisAdd BLAST | 21 | |
Compositional biasi | 1486 – 1501 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1623 – 1637 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1638 – 1658 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 1674 – 1700 | PolarSequence analysisAdd BLAST | 27 | |
Compositional biasi | 1782 – 1814 | PolarSequence analysisAdd BLAST | 33 | |
Compositional biasi | 1885 – 1948 | PolarSequence analysisAdd BLAST | 64 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000155474 |
HOGENOMi | CLU_000550_0_1_1 |
OrthoDBi | 27514at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR024678, Kinase_OSR1/WNK_CCT IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF12202, OSR1_C, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
F5GWT4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGGAAEKQS STPGSLFLSP PAPAPKNGSS SDSSVGEKLG AAAADAVTGR
60 70 80 90 100
TEEYRRRRHT MDKDSRGAAA TTTTTEHRFF RRSVICDSNA TALELPGLPL
110 120 130 140 150
SLPQPSIPAA VPQSAPPEPH REETVTATAT SQVAQQPPAA AAPGEQAVAG
160 170 180 190 200
PAPSTVPSST SKDRPVSQPS LVGSKEEPPP ARSGSGGGSA KEPQEERSQQ
210 220 230 240 250
QDDIEELETK AVGMSNDGRF LKFDIEIGRG SFKTVYKGLD TETTVEVAWC
260 270 280 290 300
ELQDRKLTKS ERQRFKEEAE MLKGLQHPNI VRFYDSWEST VKGKKCIVLV
310 320 330 340 350
TELMTSGTLK TYLKRFKVMK IKVLRSWCRQ ILKGLQFLHT RTPPIIHRDL
360 370 380 390 400
KCDNIFITGP TGSVKIGDLG LATLKRASFA KSVIGTPEFM APEMYEEKYD
410 420 430 440 450
ESVDVYAFGM CMLEMATSEY PYSECQNAAQ IYRRVTSGVK PASFDKVAIP
460 470 480 490 500
EVKEIIEGCI RQNKDERYSI KDLLNHAFFQ EETGVRVELA EEDDGEKIAI
510 520 530 540 550
KLWLRIEDIK KLKGKYKDNE AIEFSFDLER DVPEDVAQEM VESGYVCEGD
560 570 580 590 600
HKTMAKAIKD RVSLIKRKRE QRQLVREEQE KKKQEESSLK QQVEQSSASQ
610 620 630 640 650
TGIKQLPSAS TGIPTASTTS ASVSTQVEPE EPEADQHQQL QYQQPSISVL
660 670 680 690 700
SDGTVDSGQG SSVFTESRVS SQQTVSYGSQ HEQAHSTGTV PGHIPSTVQA
710 720 730 740 750
QSQPHGVYPP SSVAQGQSQG QPSSSSLTGV SSSQPIQHPQ QQGIQQTAPP
760 770 780 790 800
QQTVQYSLSQ TSTSSEATTA QPVSQPQAPQ VLPQVSAGKQ STQGVSQVAP
810 820 830 840 850
AEPVAVAQTQ ATQPTTLASS VDSAHSDVAS GMSDGNENVP SSSGRHEGRT
860 870 880 890 900
TKRHYRKSVR SRSRHEKTSR PKLRILNVSN KGDRVVECQL ETHNRKMVTF
910 920 930 940 950
KFDLDGDNPE EIATIMVNND FILAIERESF VDQVREIIEK ADEMLSEDVS
960 970 980 990 1000
VEPEGDQGLE SLQGKDDYGF SGSQKLEGEF KQPIPASSMP QQIGIPTSSL
1010 1020 1030 1040 1050
TQVVHSAGRR FIVSPVPESR LRESKVFPSE ITDTVAASTA QSPGMNLSHS
1060 1070 1080 1090 1100
ASSLSLQQAF SELRRAQMTE GPNTAPPNFS HTGPTFPVVP PFLSSIAGVP
1110 1120 1130 1140 1150
TTAAATAPVP ATSSPPNDIS TSVIQSEVTV PTEEGIAGVA TSTGVVTSGG
1160 1170 1180 1190 1200
LPIPPVSESP VLSSVVSSIT IPAVVSISTT SPSLQVPTST SEIVVSSTAL
1210 1220 1230 1240 1250
YPSVTVSATS ASAGGSTATP GPKPPAVVSQ QAAGSTTVGA TLTSVSTTTS
1260 1270 1280 1290 1300
FPSTASQLCI QLSSSTSTPT LAETVVVSAH SLDKTSHSST TGLAFSLSAP
1310 1320 1330 1340 1350
SSSSSPGAGV SSYISQPGGL HPLVIPSVIA STPILPQAAG PTSTPLLPQV
1360 1370 1380 1390 1400
PSIPPLVQPV ANVPAVQQTL IHSQPQPALL PNQPHTHCPE VDSDTQPKAP
1410 1420 1430 1440 1450
GIDDIKTLEE KLRSLFSEHS SSGAQHASVS LETSLVIEST VTPGIPTTAV
1460 1470 1480 1490 1500
APSKLLTSTT STCLPPTNLP LGTVALPVTP VVTPGQVSTP VSTTTSGVKP
1510 1520 1530 1540 1550
GTAPSKPPLT KAPVLPVGTE LPAGTLPSEQ LPPFPGPSLT QSQQPLEDLD
1560 1570 1580 1590 1600
AQLRRTLSPE MITVTSAVGP VSMAAPTAIT EAGTQPQKVS QVKEGPVLAT
1610 1620 1630 1640 1650
SSGAGVFKMG RFQVSVAADG AQKEGKNKSE DAKSVHFESS TSESSVLSSS
1660 1670 1680 1690 1700
SPESTLVKPE PNGITIPGIS SDVPESAHKT TASEAKSDTG QPTKVGRFQV
1710 1720 1730 1740 1750
TTTANKVGRF SVSKTEDKIT DTKKEGPVAS PPFMDLEQAV LPAVIPKKEK
1760 1770 1780 1790 1800
PELSEPSHLN GPSSDPEAAF LSRDVDDGSG SPHSPHQLSS KSLPSQNLSQ
1810 1820 1830 1840 1850
SLSNSFNSSY MSSDNESDIE DEDLKLELRR LRDKHLKEIQ DLQSRQKHEI
1860 1870 1880 1890 1900
ESLYTKLGKV PPAVIIPPAA PLSGRRRRPT KSKGSKSSRS SSLGNKSPQL
1910 1920 1930 1940 1950
SGNLSGQSAA SVLHPQQTLH PPGNIPESGQ NQLLQPLKPS PSSDNLYSAF
1960 1970 1980 1990 2000
TSDGAISVPS LSAPGQGTSS TNTVGATVNS QAAQAQPPAM TSSRKGTFTD
2010 2020 2030 2040 2050
DLHKLVDNWA RDAMNLSGRR GSKGHMNYEG PGMARKFSAP GQLCISMTSN
2060 2070 2080 2090 2100
LGGSAPISAA SATSLGHFTK SMCPPQQYGF PATPFGAQWS GTGGPAPQPL
2110 2120 2130
GQFQPVGTAS LQNFNISNLQ KSISNPPGSN LRTT
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9H4A3 | WNK1_HUMAN | Serine/threonine-protein kinase WNK... | WNK1 HSN2, KDP, KIAA0344, PRKWNK1 | 2,382 | Annotation score: | ||
F6UYG0 | F6UYG0_HUMAN | Serine/threonine-protein kinase WNK... | WNK1 | 393 | Annotation score: | ||
A0A6Q8PFM0 | A0A6Q8PFM0_HUMAN | Serine/threonine-protein kinase WNK... | WNK1 | 1,531 | Annotation score: | ||
H0YF81 | H0YF81_HUMAN | Serine/threonine-protein kinase WNK... | WNK1 | 76 | Annotation score: | ||
H0YH68 | H0YH68_HUMAN | Serine/threonine-protein kinase WNK... | WNK1 | 194 | Annotation score: | ||
H0YH79 | H0YH79_HUMAN | Serine/threonine-protein kinase WNK... | WNK1 | 176 | Annotation score: | ||
I3L251 | I3L251_HUMAN | Serine/threonine-protein kinase WNK... | WNK1 | 240 | Annotation score: | ||
H0YFP5 | H0YFP5_HUMAN | Serine/threonine-protein kinase WNK... | WNK1 | 245 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004765 Genomic DNA No translation available. AC004803 Genomic DNA No translation available. |
RefSeqi | NP_055638.2, NM_014823.2 |
Genome annotation databases
Ensembli | ENST00000535572; ENSP00000441972; ENSG00000060237 |
GeneIDi | 65125 |
UCSCi | uc001qip.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004765 Genomic DNA No translation available. AC004803 Genomic DNA No translation available. |
RefSeqi | NP_055638.2, NM_014823.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | F5GWT4, 6 interactors |
Proteomic databases
EPDi | F5GWT4 |
MaxQBi | F5GWT4 |
PeptideAtlasi | F5GWT4 |
PRIDEi | F5GWT4 |
ProteomicsDBi | 24212 |
Protocols and materials databases
Antibodypediai | 22083, 595 antibodies |
DNASUi | 65125 |
Genome annotation databases
Ensembli | ENST00000535572; ENSP00000441972; ENSG00000060237 |
GeneIDi | 65125 |
UCSCi | uc001qip.5, human |
Organism-specific databases
CTDi | 65125 |
HGNCi | HGNC:14540, WNK1 |
OpenTargetsi | ENSG00000060237 |
VEuPathDBi | HostDB:ENSG00000060237.16 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155474 |
HOGENOMi | CLU_000550_0_1_1 |
OrthoDBi | 27514at2759 |
Enzyme and pathway databases
SignaLinki | F5GWT4 |
Miscellaneous databases
BioGRID-ORCSi | 65125, 555 hits in 1045 CRISPR screens |
ChiTaRSi | WNK1, human |
GenomeRNAii | 65125 |
Gene expression databases
Bgeei | ENSG00000060237, Expressed in corpus callosum and 249 other tissues |
ExpressionAtlasi | F5GWT4, baseline and differential |
Genevisiblei | F5GWT4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR024678, Kinase_OSR1/WNK_CCT IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF12202, OSR1_C, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F5GWT4_HUMAN | |
Accessioni | F5GWT4Primary (citable) accession number: F5GWT4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 28, 2011 |
Last sequence update: | June 28, 2011 | |
Last modified: | April 7, 2021 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |