UniProtKB - F5GWP8 (F5GWP8_HUMAN)
Protein
Submitted name:
Keratin, type I cytoskeletal 17
Gene
KRT17
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- structural molecule activity Source: InterPro
Enzyme and pathway databases
SignaLinki | F5GWP8 |
Names & Taxonomyi
Protein namesi | Submitted name: Keratin, type I cytoskeletal 17Imported |
Gene namesi | Name:KRT17Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6427, KRT17 |
VEuPathDBi | HostDB:ENSG00000128422.15 |
Subcellular locationi
Cytoskeleton
- intermediate filament Source: UniProtKB-KW
- intermediate filament cytoskeleton Source: HPA
Keywords - Cellular componenti
Intermediate filamentUniRule annotationARBA annotationPTM / Processingi
Proteomic databases
EPDi | F5GWP8 |
PeptideAtlasi | F5GWP8 |
PRIDEi | F5GWP8 |
ProteomicsDBi | 24178 |
PTM databases
MetOSitei | F5GWP8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000128422, Expressed in amniotic fluid and 194 other tissues |
ExpressionAtlasi | F5GWP8, baseline and differential |
Interactioni
Binary interactionsi
F5GWP8
With | #Exp. | IntAct |
---|---|---|
TRIM69 [Q86WT6] | 3 | EBI-10177711,EBI-749955 |
Protein-protein interaction databases
IntActi | F5GWP8, 12 interactors |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 312 | IF rodInterPro annotationAdd BLAST | 312 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 104 – 149 | Sequence analysisAdd BLAST | 46 | |
Coiled coili | 166 – 190 | Sequence analysisAdd BLAST | 25 | |
Coiled coili | 210 – 251 | Sequence analysisAdd BLAST | 42 | |
Coiled coili | 256 – 297 | Sequence analysisAdd BLAST | 42 |
Sequence similaritiesi
Belongs to the intermediate filament family.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000160681 |
HOGENOMi | CLU_012560_8_2_1 |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit |
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR042180, IF_rod_dom_coil1B IPR002957, Keratin_I |
PANTHERi | PTHR23239, PTHR23239, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit |
PRINTSi | PR01248, TYPE1KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
F5GWP8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAALGVLMG CWLEVRRPPC RTSMANTELE VKIRDWYQRQ APGPARDYSQ
60 70 80 90 100
YYRTIEELQN KILTATVDNA NILLQIDNAR LAADDFRTKF ETEQALRLSV
110 120 130 140 150
EADINGLRRV LDELTLARAD LEMQIENLKE ELAYLKKNHE EEMNALRGQV
160 170 180 190 200
GGEINVEMDA APGVDLSRIL NEMRDQYEKM AEKNRKDAED WFFSKTEELN
210 220 230 240 250
REVATNSELV QSGKSEISEL RRTMQALEIE LQSQLSMKAS LEGNLAETEN
260 270 280 290 300
RYCVQLSQIQ GLIGSVEEQL AQLRCEMEQQ NQEYKILLDV KTRLEQEIAT
310 320 330 340
YRRLLEGEDA HLTQYKKEPV TTRQVRTIVE EVQDGKVISS REQVHQTTR
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ04695 | K1C17_HUMAN | Keratin, type I cytoskeletal 17 | KRT17 | 432 | Annotation score: | ||
K7EPJ9 | K7EPJ9_HUMAN | Keratin, type I cytoskeletal 17 | KRT17 | 231 | Annotation score: | ||
A0A3B3IS58 | A0A3B3IS58_HUMAN | Keratin, type I cytoskeletal 17 | KRT17 | 98 | Annotation score: | ||
K7ESE1 | K7ESE1_HUMAN | Keratin, type I cytoskeletal 17 | KRT17 | 95 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC130686 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000540235; ENSP00000441751; ENSG00000128422 |
UCSCi | uc060fcd.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC130686 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | F5GWP8, 12 interactors |
PTM databases
MetOSitei | F5GWP8 |
Proteomic databases
EPDi | F5GWP8 |
PeptideAtlasi | F5GWP8 |
PRIDEi | F5GWP8 |
ProteomicsDBi | 24178 |
Protocols and materials databases
Antibodypediai | 6491, 1192 antibodies |
Genome annotation databases
Ensembli | ENST00000540235; ENSP00000441751; ENSG00000128422 |
UCSCi | uc060fcd.1, human |
Organism-specific databases
HGNCi | HGNC:6427, KRT17 |
OpenTargetsi | ENSG00000128422 |
VEuPathDBi | HostDB:ENSG00000128422.15 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000160681 |
HOGENOMi | CLU_012560_8_2_1 |
Enzyme and pathway databases
SignaLinki | F5GWP8 |
Miscellaneous databases
ChiTaRSi | KRT17, human |
Gene expression databases
Bgeei | ENSG00000128422, Expressed in amniotic fluid and 194 other tissues |
ExpressionAtlasi | F5GWP8, baseline and differential |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit |
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR042180, IF_rod_dom_coil1B IPR002957, Keratin_I |
PANTHERi | PTHR23239, PTHR23239, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit |
PRINTSi | PR01248, TYPE1KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F5GWP8_HUMAN | |
Accessioni | F5GWP8Primary (citable) accession number: F5GWP8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 28, 2011 |
Last sequence update: | October 29, 2014 | |
Last modified: | April 7, 2021 | |
This is version 84 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |