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Entry version 34 (31 Jul 2019)
Sequence version 1 (28 Jun 2011)
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Protein
Submitted name:

Low-density lipoprotein receptor-related protein 6

Gene

G5I_13753

Organism
Acromyrmex echinatior (Panamanian leafcutter ant) (Acromyrmex octospinosus echinatior)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Low-density lipoprotein receptor-related protein 6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:G5I_13753Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAcromyrmex echinatior (Panamanian leafcutter ant) (Acromyrmex octospinosus echinatior)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri103372 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataFormicoideaFormicidaeMyrmicinaeAcromyrmex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007755 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1391 – 1412HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1279 ↔ 1294PROSITE-ProRule annotation
Disulfide bondi1315 ↔ 1330PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation, LipoproteinImported

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
103372.F4X5W2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati46 – 91LDL-receptor class BPROSITE-ProRule annotationAdd BLAST46
Repeati92 – 134LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati135 – 180LDL-receptor class BPROSITE-ProRule annotationAdd BLAST46
Repeati181 – 223LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini273 – 311EGF-likeInterPro annotationAdd BLAST39
Repeati359 – 401LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati402 – 444LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati445 – 489LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati490 – 532LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati533 – 573LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Domaini581 – 619EGF-likeInterPro annotationAdd BLAST39
Repeati665 – 707LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati708 – 750LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati751 – 793LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati794 – 831LDL-receptor class BPROSITE-ProRule annotationAdd BLAST38
Repeati835 – 877LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Domaini884 – 928EGF-likeInterPro annotationAdd BLAST45
Repeati976 – 1022LDL-receptor class BPROSITE-ProRule annotationAdd BLAST47
Repeati1023 – 1066LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati1067 – 1109LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1110 – 1133LDL-receptor class BPROSITE-ProRule annotationAdd BLAST24
Repeati1148 – 1194LDL-receptor class BPROSITE-ProRule annotationAdd BLAST47
Domaini1202 – 1249EGF-likeInterPro annotationAdd BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1483 – 1615DisorderedSequence analysisAdd BLAST133

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1483 – 1534PolarSequence analysisAdd BLAST52
Compositional biasi1584 – 1602PolarSequence analysisAdd BLAST19

Keywords - Domaini

EGF-like domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F4X5W2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112 LDLa, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 4 hits
4.10.400.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR000033 LDLR_classB_rpt
IPR002172 LDrepeatLR_classA_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00057 Ldl_recept_a, 3 hits
PF00058 Ldl_recept_b, 11 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261 LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 4 hits
SM00192 LDLa, 3 hits
SM00135 LY, 20 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57424 SSF57424, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01186 EGF_2, 1 hit
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 3 hits
PS51120 LDLRB, 19 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

F4X5W2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
FLGSPLLLFG THKDIRVTNI SRSNKVNIII KDLSEGASLD FFYERELICW
60 70 80 90 100
SDSNLEMIQC IHYNGTHTGE KITVVNSSLI SPDGLACDWF TDKLYWTDGE
110 120 130 140 150
KNRIEVTSID GRNRKVLFWN DIYQPRAIAL APMEGYLFWT DWGDVPKIER
160 170 180 190 200
ASMDGDPNTR EIIVSDDIFW PNGLTIDYEN RLVYWADGRL HFIAVMDYHG
210 220 230 240 250
GNKRKLITRN LDYPFAITFF DNRLYWTDWK TWCIHSYDIN QPQSHPRELF
260 270 280 290 300
HGEYIPGDIE VWDARRQPGS NNPCKRNNGN CSHLCLLSSK EPGYSCACPT
310 320 330 340 350
GVKLIDKHTC ANRPEQLLLI VQRTEICRIS LDSPDYTNFV LPLTGIKHAI
360 370 380 390 400
AIDFDPAEEL LYWTDEQTTT IRRAPLDGMS QQNVISTEVA NPDGIAIDWI
410 420 430 440 450
ARNLYWTDTG TDRIEVARLD GKYRRVLVNE DLFEPRAIAL APEHGWMFWT
460 470 480 490 500
DWSEKRPKIE RSNLDGSERI LLITKDIVWP NGIALDLERN KIYWCDAKTD
510 520 530 540 550
KIEVSNMDGT DRREVITDNL PHLFGLTLLG DYLYWTDWQR RSIDRAHKLT
560 570 580 590 600
GGEREVIVDQ VPNVMGIKAI HLGKMNASNS PCAHDNGGCS HLCFNRPNNR
610 620 630 640 650
YVCACQMGYE LTKDKRTCVV PEAFLLFSRR ENLGRISIEN INNDNIIPVT
660 670 680 690 700
GIKDASAIDF DLSENRIYWT DIKLKTITRV FINGSDIEKI VDLGLESPEG
710 720 730 740 750
IAFDWIAHNL YWSDTITRRI EMIRIEGGSR KILLWQNLLE PKNVAVDPER
760 770 780 790 800
GHLYWAEWGN TGSIERAFLD GTQRQVIVSH IGRANGLTID HVGRKLYWAD
810 820 830 840 850
ISTPAINCYD LLTQRGDVII SRHIVYPFSV TQYRDFIYWA DWNTGDIERA
860 870 880 890 900
DKITGANRTK IHTNLASVTD LKVFHASRQS GSNPCAIANG NCSHLCIALP
910 920 930 940 950
DSNGGASVIH KCACPTHYNL ARDNRTCMAP RHFMIYSQRT AIVRYLPDQT
960 970 980 990 1000
DDCADVTLRV QGLKNVRAIE FDPVTQHVYW IDGRMTIRRA LENQTQQQQH
1010 1020 1030 1040 1050
SSTVVVSIGN GHLFDLALDP LGRLLFWTCS TNDALNVTRL DNGSALGIVV
1060 1070 1080 1090 1100
KGDGEKPRHI AIYSQQRLLF WTDVGKKRVV RSKMDGKERH VIAGDLLEQP
1110 1120 1130 1140 1150
TGLTVDTTTY AVYWAYSKHI ECSNFEGNDR KLLTSTQGSA LHLAILFNYL
1160 1170 1180 1190 1200
YWYDRDAQVI ERVNKTFDGN TRRGTQVTTG RISFTDLIAI NMPEDLLMET
1210 1220 1230 1240 1250
HVCSPFNDYG GCSHFCVGTN TIADEATATL PRCSCPKSLV LSDDGRTCRA
1260 1270 1280 1290 1300
APVCGNDHFT CAAPNAAVSK DCIPATWKCD GQTDCSDGSD ELGCPTCSRD
1310 1320 1330 1340 1350
QFRCQNHCIE LSLVCDGTQQ CPDGSDEAQC CEIGQFQCVG NGVCISGTSL
1360 1370 1380 1390 1400
CDGWDDCADG SDEIPPACMS PHNPHRQNAG PGINESGKTT YIIIILAVVF
1410 1420 1430 1440 1450
VVGTSILSYY YCRKKFIGNE GLPDILHDSA GDPLSPKPSN NRMVKPMFVS
1460 1470 1480 1490 1500
QKNNRKDGGA SGGLKVGMEA IRMSMLNGSS LGSSYDRSHI TGASSSTRGS
1510 1520 1530 1540 1550
SAGGYPQETL NPPPSPATIV SSTRCSSSNA SRYKPYRHYR SINQPPPPTP
1560 1570 1580 1590 1600
CSTDVCDESD SNYPARYRYE SEPFPPPPTP RSVYHSDAAN SCPPSPSSRS
1610
STYFSPLPPP PSPVP
Length:1,615
Mass (Da):181,192
Last modified:June 28, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i070AF31A1F18EC70
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GL888742 Genomic DNA Translation: EGI58202.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL888742 Genomic DNA Translation: EGI58202.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi103372.F4X5W2

Phylogenomic databases

InParanoidiF4X5W2

Family and domain databases

CDDicd00112 LDLa, 3 hits
Gene3Di2.120.10.30, 4 hits
4.10.400.10, 3 hits
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR000033 LDLR_classB_rpt
IPR002172 LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 3 hits
PF00058 Ldl_recept_b, 11 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00181 EGF, 4 hits
SM00192 LDLa, 3 hits
SM00135 LY, 20 hits
SUPFAMiSSF57424 SSF57424, 3 hits
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 3 hits
PS51120 LDLRB, 19 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF4X5W2_ACREC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F4X5W2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: July 31, 2019
This is version 34 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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