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Entry version 58 (16 Oct 2019)
Sequence version 1 (28 Jun 2011)
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Protein

Transmembrane 9 superfamily member 8

Gene

TMN8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane 9 superfamily member 8Curated
Alternative name(s):
Endomembrane protein 11 Publication
Transmembrane nine protein 81 Publication
Short name:
AtTMN81 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMN81 Publication
Synonyms:EMP11 Publication
Ordered Locus Names:At5g10840Imported
ORF Names:T30N20_110Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G10840

The Arabidopsis Information Resource

More...
TAIRi
locus:2183710 AT5G10840

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini34 – 285LumenalCuratedAdd BLAST252
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei286 – 306Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini307 – 355CytoplasmicCuratedAdd BLAST49
Transmembranei356 – 376Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini377 – 381LumenalCurated5
Transmembranei382 – 402Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini403 – 422CytoplasmicCuratedAdd BLAST20
Transmembranei423 – 443Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini444 – 455LumenalCuratedAdd BLAST12
Transmembranei456 – 476Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini477 – 506CytoplasmicCuratedAdd BLAST30
Transmembranei507 – 527Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini528 – 538LumenalCuratedAdd BLAST11
Transmembranei539 – 559Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini560 – 577CytoplasmicCuratedAdd BLAST18
Transmembranei578 – 598Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini599 – 604LumenalCurated6
Transmembranei605 – 625Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini626 – 648CytoplasmicCuratedAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000043126534 – 648Transmembrane 9 superfamily member 8Sequence analysisAdd BLAST615

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F4KIB2

PRoteomics IDEntifications database

More...
PRIDEi
F4KIB2

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
F4KIB2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F4KIB2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
F4KIB2 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
16229, 32 interactors

Protein interaction database and analysis system

More...
IntActi
F4KIB2, 32 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT5G10840.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi637 – 642Endoplasmic reticulum export signalBy similarity6
Motifi646 – 648Golgi retention signalBy similarity3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal KXD/E motif functions as a Golgi retention signal, certainly through the binding to the COP1 coatomer.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1278 Eukaryota
ENOG410XPIW LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000216679

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F4KIB2

KEGG Orthology (KO)

More...
KOi
K17086

Identification of Orthologs from Complete Genome Data

More...
OMAi
KYCTTGF

Database of Orthologous Groups

More...
OrthoDBi
641127at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004240 EMP70
IPR036259 MFS_trans_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10766 PTHR10766, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02990 EMP70, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

F4KIB2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMEFLRSSR RILESSGCAI ALIFLLFIHG AHSFYLPGVA PQDFEKGDEL
60 70 80 90 100
KVKVNKLTSI KTQLPYSYYS LPFCRPSKIV DSTENLGEVL RGDRIENAPY
110 120 130 140 150
SFKMREAQMC NILGRVTLDA KTAKAFKEKI DDEYRVNMIL DNLPLVVPIE
160 170 180 190 200
RVDQGSPSVV YQLGYHVGLK GQYEGSKEQK FFMHNHLAFT VRYHRDIQTD
210 220 230 240 250
AARIVGFEVK PYSVKHEYEG EWSEKTRLTT CDPHTKRLVV SSATPQEVEQ
260 270 280 290 300
KKEIIFTYDV DFQESEVKWA SRWDTYLLMS DNQIHWFSIV NSLMIVLFLS
310 320 330 340 350
GMVAMIMLRT LYRDISRYNE LETQEEAQEE TGWKLVHGDV FRLPTNSDLL
360 370 380 390 400
CVYVGTGVQC LGMVFVTMIF AMLGFLSPSN RGGLMTAMLL LWVFMGLFAG
410 420 430 440 450
YASSRLYKMF KGTEWKRIAF RTAFLFPAVV SAIFFVLNAL IWGQKSSGAV
460 470 480 490 500
PFGTMFALIF LWFGISVPLV FVGGYIGFKK PAADDPVKTN KIPRQIPEQA
510 520 530 540 550
WYMNPVFSIL IGGILPFGAV FIELFFILTS IWLNQFYYIF GFLFLVFVIL
560 570 580 590 600
IVTCAEITVV LCYFQLCSED YLWWWRSYLT SGSSALYLFL YATFYFFTKL
610 620 630 640
QITKLVSAML YFGYMLIASY AFFVLTGTIG FYACLWFTRL IYSSVKID
Length:648
Mass (Da):74,467
Last modified:June 28, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2E22FC979A8360E
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BX833631 differs from that shown. Reason: Frameshift.Curated
The sequence CAB96839 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti570D → E in BX833631 (PubMed:14993207).1
Sequence conflicti592A → T in BX833631 (PubMed:14993207).1
Sequence conflicti612F → L in BX833631 (PubMed:14993207).1
Sequence conflicti623F → I in BX833631 (PubMed:14993207).1
Sequence conflicti634C → Y in BX833631 (PubMed:14993207).1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL365234 Genomic DNA Translation: CAB96839.1 Sequence problems.
CP002688 Genomic DNA Translation: AED91602.1
BX833631 mRNA No translation available.

Protein sequence database of the Protein Information Resource

More...
PIRi
T50793

NCBI Reference Sequences

More...
RefSeqi
NP_196645.2, NM_121122.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G10840.1; AT5G10840.1; AT5G10840

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
830951

Gramene; a comparative resource for plants

More...
Gramenei
AT5G10840.1; AT5G10840.1; AT5G10840

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G10840

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365234 Genomic DNA Translation: CAB96839.1 Sequence problems.
CP002688 Genomic DNA Translation: AED91602.1
BX833631 mRNA No translation available.
PIRiT50793
RefSeqiNP_196645.2, NM_121122.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi16229, 32 interactors
IntActiF4KIB2, 32 interactors
STRINGi3702.AT5G10840.1

PTM databases

SwissPalmiF4KIB2

Proteomic databases

PaxDbiF4KIB2
PRIDEiF4KIB2

Genome annotation databases

EnsemblPlantsiAT5G10840.1; AT5G10840.1; AT5G10840
GeneIDi830951
GrameneiAT5G10840.1; AT5G10840.1; AT5G10840
KEGGiath:AT5G10840

Organism-specific databases

AraportiAT5G10840
TAIRilocus:2183710 AT5G10840

Phylogenomic databases

eggNOGiKOG1278 Eukaryota
ENOG410XPIW LUCA
HOGENOMiHOG000216679
InParanoidiF4KIB2
KOiK17086
OMAiKYCTTGF
OrthoDBi641127at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:F4KIB2

Gene expression databases

ExpressionAtlasiF4KIB2 baseline and differential
GenevisibleiF4KIB2 AT

Family and domain databases

InterProiView protein in InterPro
IPR004240 EMP70
IPR036259 MFS_trans_sf
PANTHERiPTHR10766 PTHR10766, 1 hit
PfamiView protein in Pfam
PF02990 EMP70, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMN8_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F4KIB2
Secondary accession number(s): Q9LEV5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 26, 2014
Last sequence update: June 28, 2011
Last modified: October 16, 2019
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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