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Entry version 70 (29 Sep 2021)
Sequence version 1 (28 Jun 2011)
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Protein
Submitted name:

RNA-binding KH domain-containing protein

Gene

HEN4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: TAIR

GO - Biological processi

  • mRNA processing Source: TAIR
  • specification of floral organ identity Source: TAIR

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
RNA-binding KH domain-containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HEN4Imported
Synonyms:HUA ENHANCER 4Imported, MSJ1.23Imported, MSJ1_23Imported
Ordered Locus Names:At5g64390Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G64390

The Arabidopsis Information Resource

More...
TAIRi
locus:2173378, AT5G64390

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F4KDM9

PRoteomics IDEntifications database

More...
PRIDEi
F4KDM9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
206321

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F4KDM9, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F4KDM9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 115KHInterPro annotationAdd BLAST71
Domaini148 – 222KHInterPro annotationAdd BLAST75
Domaini450 – 523KHInterPro annotationAdd BLAST74
Domaini540 – 615KHInterPro annotationAdd BLAST76
Domaini783 – 853KHInterPro annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27
Regioni644 – 755DisorderedSequence analysisAdd BLAST112

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi644 – 688Polar residuesSequence analysisAdd BLAST45

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_018025_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F4KDM9

Database of Orthologous Groups

More...
OrthoDBi
286875at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1370.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004087, KH_dom
IPR004088, KH_dom_type_1
IPR036612, KH_dom_type_1_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00013, KH_1, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00322, KH, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54791, SSF54791, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F4KDM9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERNSVKFHA EKRSGAFDPG SGFGSSKRVK THHTQLLSAL VVPVGHAAFR
60 70 80 90 100
LLCPLSHVGA VIGKSGNVIK QLQQSTGAKI RVEEPPSGSP DRVITIIAQA
110 120 130 140 150
DSKSRVKLGA NNNGNAEGEK KEEEVEVSKA QGALIKVFEL LAAEADSDTV
160 170 180 190 200
VCRLLTESSH AGAVIGKGGQ MVGSIRKETG CKISIRIENL PICADTDDEM
210 220 230 240 250
VEVEGNAIAV KKALVSISRC LQNCQSIDKV RMVGNRPLEK EFQASLHRPI
260 270 280 290 300
ETIIQESLPR SVEVNPYDYR LRNDEIFPRG TVARANDVIP HDTLHLRRIE
310 320 330 340 350
AVPQGALRMH IEADRQDVLR RHVEADRQDA LRRRIDVVPQ ETLYMPSDVL
360 370 380 390 400
RGDCFRQHRE RDDSHDSLHR PFEMVPRDAM GMPFESFPRD AYGRPIETMT
410 420 430 440 450
QETLRGQSAD YLAHRYSTLD THPHSFTTSA SMANTATMKP PPSEVEVGNQ
460 470 480 490 500
DVVFKILCST ENAGGVIGTG GKVVRMLHSE TGAFINVGNT LDDCEERLIA
510 520 530 540 550
VTASENPECQ SSPAQKAIML IFSRLFELAT NKILDNGPRS SITARLVVPT
560 570 580 590 600
SQIGCVLGKG GVIVSEMRKT TGAAIQILKV EQNPKCISEN DQVVQITGEF
610 620 630 640 650
PNVREAIFHI TSRLRDSVFS NSMKNSLAKS SSALTTERFY DRQSDNPLSI
660 670 680 690 700
GSHQSVSNPA TNSSSLHRRS EDSFLSGSHS SVNYSRSVGT DPYIRPEDPF
710 720 730 740 750
PDRFNPSAGY SHNFGRRFTM DHSDNSHHLT EAPSRLWASP PPAAPRGLSD
760 770 780 790 800
ASGGLSSARA GHVLGSLHAR LVFSSGHKSA IVTNTTVEIR VPANAMSFVY
810 820 830 840 850
GEQGYNLEQL RQISGARVII HEPPLGTSDR IIVISGTPDQ TQAAQNLLHA
860
FILTGETSLS KKYNLN
Length:866
Mass (Da):94,704
Last modified:June 28, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5BEB15B482D18812
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F4KDN0HEN4_ARATH
KH domain-containing protein HEN4
HEN4 At5g64390
857Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F4KDN1F4KDN1_ARATH
RNA-binding KH domain-containing pr...
HEN4 HUA ENHANCER 4, MSJ1.23, MSJ1_23, At5g64390
824Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP002688 Genomic DNA Translation: AED97885.1

NCBI Reference Sequences

More...
RefSeqi
NP_001190612.1, NM_001203683.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G64390.3; AT5G64390.3; AT5G64390

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
836560

Gramene; a comparative resource for plants

More...
Gramenei
AT5G64390.3; AT5G64390.3; AT5G64390

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002688 Genomic DNA Translation: AED97885.1
RefSeqiNP_001190612.1, NM_001203683.1

3D structure databases

SMRiF4KDM9
ModBaseiSearch...

Proteomic databases

PaxDbiF4KDM9
PRIDEiF4KDM9
ProteomicsDBi206321

Genome annotation databases

EnsemblPlantsiAT5G64390.3; AT5G64390.3; AT5G64390
GeneIDi836560
GrameneiAT5G64390.3; AT5G64390.3; AT5G64390

Organism-specific databases

AraportiAT5G64390
TAIRilocus:2173378, AT5G64390

Phylogenomic databases

HOGENOMiCLU_018025_3_1_1
InParanoidiF4KDM9
OrthoDBi286875at2759

Gene expression databases

ExpressionAtlasiF4KDM9, baseline and differential

Family and domain databases

Gene3Di3.30.1370.10, 3 hits
InterProiView protein in InterPro
IPR004087, KH_dom
IPR004088, KH_dom_type_1
IPR036612, KH_dom_type_1_sf
PfamiView protein in Pfam
PF00013, KH_1, 5 hits
SMARTiView protein in SMART
SM00322, KH, 5 hits
SUPFAMiSSF54791, SSF54791, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF4KDM9_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F4KDM9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 29, 2021
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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