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Entry version 78 (02 Jun 2021)
Sequence version 1 (28 Jun 2011)
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Protein

Leucine-rich repeat receptor-like serine/threonine-protein kinase RGI4

Gene

RGI4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor with a serine/threonine-protein kinase activity (By similarity).

Together with SKM1, LRR-rich receptor-like kinase (LRR-RLK) required for male fertility by the perception of CLE43 and CLE45 peptides and the transduction of their promoting action in pollen tubes, especially under relatively high temperature (at 30 degrees Celsius), thus conferring tolerance against high temperature probably through the maintenance of mitochondrial activity (PubMed:23910659).

Seems to not be involved in the perception of CLE45 peptide in roots (PubMed:27354416).

Together with RGI1, RGI2, RGI3, RGI4 and RGI5, acts as receptor of RGF1, a peptide hormone that maintains the postembryonic root stem cell niche by regulating the expression levels and patterns of the transcription factor PLETHORA (PLT) (PubMed:27229312, PubMed:27229311).

Links RGF1 signal with its downstream components (PubMed:27229311).

By similarity4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei786ATPPROSITE-ProRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei786Essential for autophosphorylation activityBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei882Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi764 – 772ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat receptor-like serine/threonine-protein kinase RGI41 Publication (EC:2.7.11.1PROSITE-ProRule annotation)
Alternative name(s):
Protein RECEPTOR OF RGF1 21 Publication
Protein RGF1 INSENSITIVE 41 Publication
Protein STERILITY-REGULATING KINASE MEMBER 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RGI41 Publication
Synonyms:RGFR21 Publication, SKM21 Publication
Ordered Locus Names:At5g56040Imported
ORF Names:MDA7.8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G56040

The Arabidopsis Information Resource

More...
TAIRi
locus:2161825, AT5G56040

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 702ExtracellularCuratedAdd BLAST682
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei703 – 723HelicalSequence analysisAdd BLAST21
Topological domaini724 – 1090CytoplasmicCuratedAdd BLAST367

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Smaller root meristem size and fewer root meristematic cortex cells, associated with shorter roots and a slighty reduced sensitivity to RGF1 (PubMed:27229311). Insensitivity of pollen tubes to CLE43 and, partially, to CLE45 peptides-mediated growth stimulation (PubMed:23910659). Pollen tubes of plants missing both SKM1 and SKM2 are fully insensitive to CLE45 peptides (PubMed:23910659). Quintuple mutants rgi1 rgi2 rgi3 rgi4 rgi5 display a consistent short primary root phenotype with a small size of meristem associated with a total insensitivity to RGF1 and undetectable levels of PLT1 and PLT2 (PubMed:27229312).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500995498021 – 1090Leucine-rich repeat receptor-like serine/threonine-protein kinase RGI4Add BLAST1070

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi43N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi60 ↔ 67By similarity
Glycosylationi107N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi263N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi359N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi420N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi434N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi455N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi606N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi653N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei829PhosphotyrosineBy similarity1
Modified residuei869PhosphotyrosineBy similarity1
Modified residuei932PhosphotyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated.By similarity
Phosphorylated and ubiquitinated upon interaction with RGF1, thus leading to activation a subsequent degradation.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F4K6B8

PRoteomics IDEntifications database

More...
PRIDEi
F4K6B8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
183811
203984 [F4K6B8-1]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in floers, pollen grains and stipules (PubMed:23910659, PubMed:27229311). Present in roots (PubMed:27354416, PubMed:27229311).3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Present throughout the root, starting from the transition zone and including transition and elongation zones, but absent from the meristem.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Slightly induced in pollen upon high-temperature exposure (HTE).1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F4K6B8, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-interacts (By similarity).

Interacts with RGF1; this interaction triggers its phosphorylation and ubiquitination and the formation of heterodimers with SERK1 (PubMed:27229311).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
F4K6B8, 43 interactors

STRING: functional protein association networks

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STRINGi
3702.AT5G56040.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F4K6B8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati36 – 59LRR 1Sequence analysisAdd BLAST24
Repeati95 – 119LRR 2Sequence analysisAdd BLAST25
Repeati120 – 143LRR 3Sequence analysisAdd BLAST24
Repeati145 – 166LRR 4Sequence analysisAdd BLAST22
Repeati168 – 191LRR 5Sequence analysisAdd BLAST24
Repeati216 – 240LRR 6Sequence analysisAdd BLAST25
Repeati242 – 264LRR 7Sequence analysisAdd BLAST23
Repeati265 – 288LRR 8Sequence analysisAdd BLAST24
Repeati289 – 312LRR 9Sequence analysisAdd BLAST24
Repeati314 – 335LRR 10Sequence analysisAdd BLAST22
Repeati336 – 360LRR 11Sequence analysisAdd BLAST25
Repeati362 – 386LRR 12Sequence analysisAdd BLAST25
Repeati408 – 432LRR 13Sequence analysisAdd BLAST25
Repeati434 – 456LRR 14Sequence analysisAdd BLAST23
Repeati457 – 480LRR 15Sequence analysisAdd BLAST24
Repeati481 – 504LRR 16Sequence analysisAdd BLAST24
Repeati506 – 526LRR 17Sequence analysisAdd BLAST21
Repeati527 – 550LRR 18Sequence analysisAdd BLAST24
Repeati551 – 574LRR 19Sequence analysisAdd BLAST24
Repeati576 – 598LRR 20Sequence analysisAdd BLAST23
Repeati600 – 622LRR 21Sequence analysisAdd BLAST23
Repeati623 – 646LRR 22Sequence analysisAdd BLAST24
Repeati647 – 670LRR 23Sequence analysisAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini758 – 1040Protein kinasePROSITE-ProRule annotationAdd BLAST283
Repeati1037 – 1060LRR 24Sequence analysisAdd BLAST24

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1054 – 1079DisorderedSequence analysisAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi176 – 177Small peptide recognitionBy similarity2
Motifi198 – 201Small peptide recognitionBy similarity4
Motifi221 – 226Small peptide recognitionBy similarity6
Motifi249Small peptide recognitionBy similarity1
Motifi269 – 273CLE45 peptide bindingBy similarity5
Motifi271 – 273Small peptide recognitionBy similarity3
Motifi319 – 322Small peptide recognitionBy similarity4
Motifi341 – 343Small peptide recognitionBy similarity3
Motifi389 – 393Small peptide recognitionBy similarity5
Motifi415 – 418Small peptide recognitionBy similarity4
Motifi437 – 441Small peptide recognitionBy similarity5
Motifi461 – 463Small peptide recognitionBy similarity3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QSU9, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_000288_22_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
F4K6B8

Identification of Orthologs from Complete Genome Data

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OMAi
HGADETW

Database of Orthologous Groups

More...
OrthoDBi
826997at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.80.10.10, 7 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR013210, LRR_N_plant-typ
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855, LRR_8, 2 hits
PF08263, LRRNT_2, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369, LRR_TYP, 9 hits
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: F4K6B8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRNPRFCFF LFLLFHSSLF FSIPCFSIDE QGLALLSWKS QLNISGDALS
60 70 80 90 100
SWKASESNPC QWVGIKCNER GQVSEIQLQV MDFQGPLPAT NLRQIKSLTL
110 120 130 140 150
LSLTSVNLTG SIPKELGDLS ELEVLDLADN SLSGEIPVDI FKLKKLKILS
160 170 180 190 200
LNTNNLEGVI PSELGNLVNL IELTLFDNKL AGEIPRTIGE LKNLEIFRAG
210 220 230 240 250
GNKNLRGELP WEIGNCESLV TLGLAETSLS GRLPASIGNL KKVQTIALYT
260 270 280 290 300
SLLSGPIPDE IGNCTELQNL YLYQNSISGS IPVSMGRLKK LQSLLLWQNN
310 320 330 340 350
LVGKIPTELG TCPELFLVDL SENLLTGNIP RSFGNLPNLQ ELQLSVNQLS
360 370 380 390 400
GTIPEELANC TKLTHLEIDN NQISGEIPPL IGKLTSLTMF FAWQNQLTGI
410 420 430 440 450
IPESLSQCQE LQAIDLSYNN LSGSIPNGIF EIRNLTKLLL LSNYLSGFIP
460 470 480 490 500
PDIGNCTNLY RLRLNGNRLA GNIPAEIGNL KNLNFIDISE NRLIGNIPPE
510 520 530 540 550
ISGCTSLEFV DLHSNGLTGG LPGTLPKSLQ FIDLSDNSLT GSLPTGIGSL
560 570 580 590 600
TELTKLNLAK NRFSGEIPRE ISSCRSLQLL NLGDNGFTGE IPNELGRIPS
610 620 630 640 650
LAISLNLSCN HFTGEIPSRF SSLTNLGTLD VSHNKLAGNL NVLADLQNLV
660 670 680 690 700
SLNISFNEFS GELPNTLFFR KLPLSVLESN KGLFISTRPE NGIQTRHRSA
710 720 730 740 750
VKVTMSILVA ASVVLVLMAV YTLVKAQRIT GKQEELDSWE VTLYQKLDFS
760 770 780 790 800
IDDIVKNLTS ANVIGTGSSG VVYRVTIPSG ETLAVKKMWS KEENRAFNSE
810 820 830 840 850
INTLGSIRHR NIIRLLGWCS NRNLKLLFYD YLPNGSLSSL LHGAGKGSGG
860 870 880 890 900
ADWEARYDVV LGVAHALAYL HHDCLPPILH GDVKAMNVLL GSRFESYLAD
910 920 930 940 950
FGLAKIVSGE GVTDGDSSKL SNRPPLAGSY GYMAPEHASM QHITEKSDVY
960 970 980 990 1000
SYGVVLLEVL TGKHPLDPDL PGGAHLVQWV RDHLAGKKDP REILDPRLRG
1010 1020 1030 1040 1050
RADPIMHEML QTLAVSFLCV SNKASDRPMM KDIVAMLKEI RQFDMDRSES
1060 1070 1080 1090
DMIKGGKCEK WQPQPLPPEK IVSTPRGSSN CSFAYSDESV
Length:1,090
Mass (Da):119,331
Last modified:June 28, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i011FD4BC2B74DCBA
GO
Isoform 2 (identifier: F4K6B8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     936-953: EHASMQHITEKSDVYSYG → GKIQNFDFNVINLSISKY
     954-1090: Missing.

Show »
Length:953
Mass (Da):103,990
Checksum:i61B62E0E4E9E4765
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB09286 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAF02094 differs from that shown. Reason: Erroneous translation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti948D → G in BAF02094 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_060889936 – 953EHASM…VYSYG → GKIQNFDFNVINLSISKY in isoform 2. Add BLAST18
Alternative sequenceiVSP_060890954 – 1090Missing in isoform 2. Add BLAST137

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB011476 Genomic DNA Translation: BAB09286.1 Sequence problems.
CP002688 Genomic DNA Translation: AED96713.1
CP002688 Genomic DNA Translation: AED96714.1
AY072083 mRNA Translation: AAL59906.1
FJ708803 mRNA Translation: ACN59394.1
AK230293 mRNA Translation: BAF02094.1 Sequence problems.

NCBI Reference Sequences

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RefSeqi
NP_001032080.1, NM_001037003.2 [F4K6B8-1]
NP_200415.2, NM_124986.3 [F4K6B8-2]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G56040.1; AT5G56040.1; AT5G56040 [F4K6B8-2]
AT5G56040.2; AT5G56040.2; AT5G56040 [F4K6B8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
835702

Gramene; a comparative resource for plants

More...
Gramenei
AT5G56040.1; AT5G56040.1; AT5G56040 [F4K6B8-2]
AT5G56040.2; AT5G56040.2; AT5G56040 [F4K6B8-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G56040

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011476 Genomic DNA Translation: BAB09286.1 Sequence problems.
CP002688 Genomic DNA Translation: AED96713.1
CP002688 Genomic DNA Translation: AED96714.1
AY072083 mRNA Translation: AAL59906.1
FJ708803 mRNA Translation: ACN59394.1
AK230293 mRNA Translation: BAF02094.1 Sequence problems.
RefSeqiNP_001032080.1, NM_001037003.2 [F4K6B8-1]
NP_200415.2, NM_124986.3 [F4K6B8-2]

3D structure databases

SMRiF4K6B8
ModBaseiSearch...

Protein-protein interaction databases

IntActiF4K6B8, 43 interactors
STRINGi3702.AT5G56040.2

Proteomic databases

PaxDbiF4K6B8
PRIDEiF4K6B8
ProteomicsDBi183811
203984 [F4K6B8-1]

Genome annotation databases

EnsemblPlantsiAT5G56040.1; AT5G56040.1; AT5G56040 [F4K6B8-2]
AT5G56040.2; AT5G56040.2; AT5G56040 [F4K6B8-1]
GeneIDi835702
GrameneiAT5G56040.1; AT5G56040.1; AT5G56040 [F4K6B8-2]
AT5G56040.2; AT5G56040.2; AT5G56040 [F4K6B8-1]
KEGGiath:AT5G56040

Organism-specific databases

AraportiAT5G56040
TAIRilocus:2161825, AT5G56040

Phylogenomic databases

eggNOGiENOG502QSU9, Eukaryota
HOGENOMiCLU_000288_22_1_1
InParanoidiF4K6B8
OMAiHGADETW
OrthoDBi826997at2759

Gene expression databases

ExpressionAtlasiF4K6B8, baseline and differential

Family and domain databases

Gene3Di3.80.10.10, 7 hits
InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR013210, LRR_N_plant-typ
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF13855, LRR_8, 2 hits
PF08263, LRRNT_2, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00369, LRR_TYP, 9 hits
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGI4_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F4K6B8
Secondary accession number(s): Q0WLB3, Q8VYG7, Q9FKU3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2021
Last sequence update: June 28, 2011
Last modified: June 2, 2021
This is version 78 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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