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Entry version 69 (11 Dec 2019)
Sequence version 1 (28 Jun 2011)
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Protein

Folylpolyglutamate synthase

Gene

FPGS1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Essential for organellar and whole-plant folate homeostasis. Required for postembryonic root development. Generates polyglutamylated folate cofactors to support C1 metabolism required for meristem maintenance and cell expansion during postembryonic root development.By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

a monovalent cationBy similarityNote: A monovalent cation.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: tetrahydrofolylpolyglutamate biosynthesis

This protein is involved in the pathway tetrahydrofolylpolyglutamate biosynthesis, which is part of Cofactor biosynthesis.By similarity
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolylpolyglutamate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi146Magnesium 1By similarity1
Metal bindingi215Magnesium 1By similarity1
Metal bindingi243Magnesium 2By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei363ATPBy similarity1
Binding sitei385ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi122 – 125ATPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
6.3.2.17 399

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00850

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Folylpolyglutamate synthaseBy similarityImported (EC:6.3.2.171 Publication)
Alternative name(s):
DHFS-FPGS homolog BImported
Folylpoly-gamma-glutamate synthetaseBy similarity
Short name:
FPGSBy similarity
Tetrahydrofolylpolyglutamate synthaseBy similarity
Short name:
Tetrahydrofolate synthaseBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FPGS11 Publication
Synonyms:ATDFB1 Publication, DFBImported, FPGS2Imported, FPGSB1 Publication
Ordered Locus Names:At5g05980
ORF Names:K18J17.17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G05980

The Arabidopsis Information Resource

More...
TAIRi
locus:2153639 AT5G05980

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Has short primary roots. Root hairs are also short and wavy. Epidermal cells of wild-type roots are two times longer than epidermal cells of the mutant roots. Short primary roots of the mutant are impaired in F-actin organization due to extensive bundling. Reduced primary root growth of mutants indicate defects in both cell division and cell expansion. Total folate content does not significantly change between the wild-type and mutant in either shoots or roots. However, differences in the accumulation patterns of some folate classes, and general changes in the contribution of each folate class to the total folate pool are found. A considerable increase in total monoglutamylated folates in mutant roots when compared with wild-type is found. This difference is not observed in shoots. Total polyglutamylated folate content is not altered in either tissue. Nucleotides and amino acids are generally depleted in mutant. Vegetative phenotype does not differ visually from wild-type. Polyglutamylated folates are still detectable in the disruption mutant. In comparison to wild-type, the plastid and mitochondrial folate levels are reduced by approximately 50 and 25%, respectively. Folate polyglutamylation levels are significantly reduced but not abolished within the respective compartments. Combined loss of FPGS1 and FPGS2 result in embryo lethality. This double mutant has abnormal seeds that are readily distinguishable as albinos which do not proceed beyond the globular stage of embryogenesis. The absence of a developing embryo lead to collapse of seed walls, leaving shrivelled seed reamnants. FPGS1 and FPGS3 double mutant exhibits dwarfed leaves, late flowering (approximately 13 days after wild-type), reduced fecundity and delayed senescence. Pollination with FPGS1 and FPGS3 double mutant pollen yield at most one or two seeds per silique compared to the yield of full siliques when wild-type stigmas are pollinated with wild-type pollen. There is a 40% reduction in the total of 5-CH3-THF pool in FPGS1 and FPGS3 double mutant leaf tissue. FPGS1 and FPGS3 double mutants have 70% lower methionine content than wild-type.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004144851 – 571Folylpolyglutamate synthaseAdd BLAST571

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F4K2A1

PRoteomics IDEntifications database

More...
PRIDEi
F4K2A1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in both shoots and roots, but expression in roots is higher compared with shoots. Distinct expression in the quiescent center (QC) region of the root tip. Also expressed in vascular tissues of the cotyledons and hypocotyls, and the first true leaves of 7 days old seedlings.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F4K2A1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
F4K2A1 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT5G05980.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the folylpolyglutamate synthase family.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2525 Eukaryota
COG0285 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000181278

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F4K2A1

KEGG Orthology (KO)

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KOi
K01930

Database of Orthologous Groups

More...
OrthoDBi
840266at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1190.10, 1 hit
3.90.190.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001645 Folylpolyglutamate_synth
IPR018109 Folylpolyglutamate_synth_CS
IPR023600 Folylpolyglutamate_synth_euk
IPR036565 Mur-like_cat_sf
IPR036615 Mur_ligase_C_dom_sf
IPR013221 Mur_ligase_cen

The PANTHER Classification System

More...
PANTHERi
PTHR11136 PTHR11136, 1 hit
PTHR11136:SF5 PTHR11136:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08245 Mur_ligase_M, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038895 FPGS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53244 SSF53244, 1 hit
SSF53623 SSF53623, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01499 folC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01011 FOLYLPOLYGLU_SYNT_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 12 Publications (identifier: F4K2A1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFAVSIVPRT TSCRLSSAFL CQLSIPLTLR LHHHYQHHQP HLPSPLSFQI
60 70 80 90 100
HSLRKQIDMA AQGGDSYEEA LAALSSLITK RSRADKSNKG DRFELVFDYL
110 120 130 140 150
KLLDLEEDIL KMNVIHVAGT KGKGSTCTFT ESIIRNYGFR TGLFTSPHLI
160 170 180 190 200
DVRERFRLDG VDISEEKFLG YFWWCYNRLK ERTNEEIPMP TYFRFLALLA
210 220 230 240 250
FKIFAAEEVD AAILEVGLGG KFDATNAVQK PVVCGISSLG YDHMEILGDT
260 270 280 290 300
LGKIAGEKAG IFKLGVPAFT VPQPDEAMRV LEEKASETEV NLEVVQPLTA
310 320 330 340 350
RLLSGQKLGL DGEHQYVNAG LAVSLASIWL QQIGKLEVPS RTQMSILPEK
360 370 380 390 400
FIKGLATASL QGRAQVVPDQ YTESRTSGDL VFYLDGAHSP ESMEACAKWF
410 420 430 440 450
SVAVKGDNQS GSSGHLVNGS AGSSHDKWSN ETCEQILLFN CMSVRDPNLL
460 470 480 490 500
LPHLKNMCAK YGVNFKKALF VPNMSVYHKV GTAADLPEND PQVDLSWQFT
510 520 530 540 550
LQKVWESLVQ SERDGEKDGE SDGNSEVFTS LPMAIKCLRD TVHESSSATR
560 570
FQVLVTGSLH LVGDVLRLIR K
Length:571
Mass (Da):63,345
Last modified:June 28, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51192CBC797BBEF4
GO
Isoform 2 (identifier: F4K2A1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.

Show »
Length:513
Mass (Da):56,638
Checksum:i081EF8A4F61826EB
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB10803 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti229Q → H in CAC80839 (PubMed:11752472).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0420871 – 58Missing in isoform 2. CuratedAdd BLAST58

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ250873 mRNA Translation: CAC80839.2
AB017060 Genomic DNA Translation: BAB10803.1 Sequence problems.
CP002688 Genomic DNA Translation: AED90949.1
CP002688 Genomic DNA Translation: AED90950.1
AK317446 mRNA Translation: BAH20113.1

NCBI Reference Sequences

More...
RefSeqi
NP_001031840.1, NM_001036763.2 [F4K2A1-2]
NP_196217.2, NM_120680.3 [F4K2A1-1]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G05980.1; AT5G05980.1; AT5G05980 [F4K2A1-1]
AT5G05980.2; AT5G05980.2; AT5G05980 [F4K2A1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
830484

Gramene; a comparative resource for plants

More...
Gramenei
AT5G05980.1; AT5G05980.1; AT5G05980 [F4K2A1-1]
AT5G05980.2; AT5G05980.2; AT5G05980 [F4K2A1-2]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G05980

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250873 mRNA Translation: CAC80839.2
AB017060 Genomic DNA Translation: BAB10803.1 Sequence problems.
CP002688 Genomic DNA Translation: AED90949.1
CP002688 Genomic DNA Translation: AED90950.1
AK317446 mRNA Translation: BAH20113.1
RefSeqiNP_001031840.1, NM_001036763.2 [F4K2A1-2]
NP_196217.2, NM_120680.3 [F4K2A1-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi3702.AT5G05980.1

Proteomic databases

PaxDbiF4K2A1
PRIDEiF4K2A1

Genome annotation databases

EnsemblPlantsiAT5G05980.1; AT5G05980.1; AT5G05980 [F4K2A1-1]
AT5G05980.2; AT5G05980.2; AT5G05980 [F4K2A1-2]
GeneIDi830484
GrameneiAT5G05980.1; AT5G05980.1; AT5G05980 [F4K2A1-1]
AT5G05980.2; AT5G05980.2; AT5G05980 [F4K2A1-2]
KEGGiath:AT5G05980

Organism-specific databases

AraportiAT5G05980
TAIRilocus:2153639 AT5G05980

Phylogenomic databases

eggNOGiKOG2525 Eukaryota
COG0285 LUCA
HOGENOMiHOG000181278
InParanoidiF4K2A1
KOiK01930
OrthoDBi840266at2759

Enzyme and pathway databases

UniPathwayiUPA00850
BRENDAi6.3.2.17 399

Miscellaneous databases

Protein Ontology

More...
PROi
PR:F4K2A1

Gene expression databases

ExpressionAtlasiF4K2A1 baseline and differential
GenevisibleiF4K2A1 AT

Family and domain databases

Gene3Di3.40.1190.10, 1 hit
3.90.190.20, 1 hit
InterProiView protein in InterPro
IPR001645 Folylpolyglutamate_synth
IPR018109 Folylpolyglutamate_synth_CS
IPR023600 Folylpolyglutamate_synth_euk
IPR036565 Mur-like_cat_sf
IPR036615 Mur_ligase_C_dom_sf
IPR013221 Mur_ligase_cen
PANTHERiPTHR11136 PTHR11136, 1 hit
PTHR11136:SF5 PTHR11136:SF5, 1 hit
PfamiView protein in Pfam
PF08245 Mur_ligase_M, 1 hit
PIRSFiPIRSF038895 FPGS, 1 hit
SUPFAMiSSF53244 SSF53244, 1 hit
SSF53623 SSF53623, 1 hit
TIGRFAMsiTIGR01499 folC, 1 hit
PROSITEiView protein in PROSITE
PS01011 FOLYLPOLYGLU_SYNT_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFPGS1_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F4K2A1
Secondary accession number(s): B9DH96
, F4K2A2, Q8W040, Q9FI88
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: June 28, 2011
Last modified: December 11, 2019
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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