UniProtKB - F4K1J4 (ATXR7_ARATH)
Protein
Histone-lysine N-methyltransferase ATXR7
Gene
ATXR7
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Histone methyltransferase involved in regulation of flowering time. Required for the expression of the flowering repressors FLC and MADS-box genes of the MAF family (PubMed:19726574, PubMed:19855050). Required for histone H3 dimethylation on 'Lys-36' H3K36me2 at the FLC locus (PubMed:19726574). Required for histone H3 trimethylation on 'Lys-4' (H3K4me3) at the FLC locus. Prevents trimethylation on 'Lys-27' (H3K27me3) at the same locus (PubMed:19855050). Involved in the control of seed dormancy and germination (PubMed:21799800).3 Publications
Catalytic activityi
- L-lysyl4-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 S-adenosyl-L-homocysteine1 PublicationEC:2.1.1.3541 Publication
- L-lysyl36-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl36-[histone H3] + 2 S-adenosyl-L-homocysteine1 PublicationEC:2.1.1.3571 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 1382 | S-adenosyl-L-methioninePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- methyltransferase activity Source: UniProtKB-KW
GO - Biological processi
- flower development Source: UniProtKB-KW
- histone H3-K36 methylation Source: TAIR
- histone H3-K4 methylation Source: TAIR
- regulation of flower development Source: TAIR
- vegetative to reproductive phase transition of meristem Source: TAIR
Keywordsi
Molecular function | Chromatin regulator, Methyltransferase, Transferase |
Biological process | Flowering, Transcription, Transcription regulation |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ATXR71 Publication Synonyms:SDG251 Publication Ordered Locus Names:At5g42400Imported ORF Names:MDH9.9Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT5G42400 |
TAIRi | locus:2162346, AT5G42400 |
Pathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000432765 | 1 – 1423 | Histone-lysine N-methyltransferase ATXR7Add BLAST | 1423 |
Proteomic databases
PaxDbi | F4K1J4 |
PRIDEi | F4K1J4 |
ProteomicsDBi | 240925 |
Expressioni
Tissue specificityi
Expressed in the shoot and root apices, vascular tissues and mesophyll cells of rosette leaves.1 Publication
Gene expression databases
ExpressionAtlasi | F4K1J4, baseline and differential |
Genevisiblei | F4K1J4, AT |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 263 – 312 | GYFPROSITE-ProRule annotationAdd BLAST | 50 | |
Domaini | 1266 – 1383 | SETPROSITE-ProRule annotationAdd BLAST | 118 |
Sequence similaritiesi
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.Curated
Phylogenomic databases
eggNOGi | KOG1080, Eukaryota |
HOGENOMi | CLU_003563_0_0_1 |
InParanoidi | F4K1J4 |
OrthoDBi | 875190at2759 |
Family and domain databases
Gene3Di | 3.30.1490.40, 2 hits |
InterProi | View protein in InterPro IPR003169, GYF IPR035445, GYF-like_dom_sf IPR044570, Set1-like IPR001214, SET_dom |
PANTHERi | PTHR45814, PTHR45814, 1 hit |
Pfami | View protein in Pfam PF00856, SET, 1 hit |
SMARTi | View protein in SMART SM00317, SET, 1 hit |
SUPFAMi | SSF55277, SSF55277, 2 hits |
PROSITEi | View protein in PROSITE PS50829, GYF, 1 hit PS50280, SET, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F4K1J4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVAVDSTFPS HGSSYSSRRK KVSALEPNYF GSMCMGVYSD DVSISAREVA
60 70 80 90 100
QDYSCDSCGD LATVSSACCN FDELCGLDSA LEMGCRSNED CRAGQEASGS
110 120 130 140 150
GIASGLDKSV PGYTMYASGW MYGNQQGQMC GPYTQQQLYD GLSTNFLPED
160 170 180 190 200
LLVYPIINGY TANSVPLKYF KQFPDHVATG FAYLQNGIIS VAPSVTSFPP
210 220 230 240 250
SSSNATVHQD EIQTEHATSA THLISHQTMP PQTSSNGSVL DQLTLNHEES
260 270 280 290 300
NMLASFLSLG NEHACWFLVD GEGRNHGPHS ILELFSWQQH GYVSDAALIR
310 320 330 340 350
DGENKLRPIT LASLIGVWRV KCGDANCDEP VTGVNFISEV SEELSVHLQS
360 370 380 390 400
GIMKIARRAL LDEIISSVIS DFLKAKKSDE HLKSYPPTSA VESISSRVIN
410 420 430 440 450
AEKSVVSNTE SAGCKNTMNE GGHSSIAAES SKYTKSVGSI ENFQTSCSAV
460 470 480 490 500
CRTLHHHCMQ IMWNAVFYDT VATHSSCWRK NKIWFRSSDI STVNYCKGSH
510 520 530 540 550
TKYSDKPESF ESFTCRVDSS SSKTAYSDEF DLATNGARVR GLSSDTYGTE
560 570 580 590 600
SVIASISEHV ENELFLSLKT HLTDYTSILI KDGANNTTSS ARDGKMHEGS
610 620 630 640 650
FREQYNLEGS SKKKNGLNVV PAKLRFSNDF SDSQRLLQEG ESSEQITSED
660 670 680 690 700
IIANIFSTAL ETSDIPVNDE LDALAIHEPP PPGCESNINM PCLRYKYQPV
710 720 730 740 750
RSKESIPEIK AYVSMALCRQ KLHNDVMRDW KSLFLKCYLN EFLASLKGSH
760 770 780 790 800
QVSRKETLAL KKRKTVTRNK KLVQSNISNQ TAEKLRKPCV GASEKVLVKR
810 820 830 840 850
SKKLSDSHSM KEVLKVDTPS IDLSVRKPSQ QKMRNTDRRD HCIIKDATKL
860 870 880 890 900
HKEKVGKDAF SKVICDKSQD LEMEDEFDDA LLITRLRRIS RNKTKELREC
910 920 930 940 950
RNAAKSCEEI SVTAEESEET VDCKDHEESL SNKPSQKVKK AHTSKLKRKN
960 970 980 990 1000
LSDARDEGTK SCNGAVKSFT EISGKEGDTE SLGLAISDKV SHQNLSKRRK
1010 1020 1030 1040 1050
SKIALFLFPG FENTSRKCFT KLLSPEDAAK NGQDMSNPTG NPPRLAEGKK
1060 1070 1080 1090 1100
FVEKSACSIS QKGRKSSQSS ILKRKHQLDE KISNVPSRRR LSLSSTDSED
1110 1120 1130 1140 1150
AVIKEDYDVR NEEKLPCHTS DKLQKGPNKL IRRRKPLAKH TTERSPIKDL
1160 1170 1180 1190 1200
SVDDGRPKPI ALKPLEKLSS KPSKKKLFLS IPKSDGCART SINGWHWHAW
1210 1220 1230 1240 1250
SLKASAEERA RVRGSSCVHM QHFGSKSSLT QNVLSARTNR AKLRNLLAAA
1260 1270 1280 1290 1300
DGADVLKMSQ LKARKKHLRF QQSKIHDWGL VALEPIEAED FVIEYVGELI
1310 1320 1330 1340 1350
RSSISEIRER QYEKMGIGSS YLFRLDDGYV LDATKRGGIA RFINHSCEPN
1360 1370 1380 1390 1400
CYTKIISVEG KKKIFIYAKR HIDAGEEISY NYKFPLEDDK IPCNCGAPNV
1410 1420
YCFCEQVPWI AKLKRRTWFS RRN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1P8BBK4 | A0A1P8BBK4_ARATH | SET domain protein 25 | SDG25 ARABIDOPSIS TRITHORAX-RELATED7, ATXR7, MDH9.9, MDH9_9, SET domain protein 25 | 1,388 | Annotation score: |
Sequence cautioni
The sequence BAB10481 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1046 | A → V in AAL01112 (PubMed:11691919).Curated | 1 | |
Sequence conflicti | 1124 | Q → K in AAL01112 (PubMed:11691919).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU014691 mRNA Translation: ABV68922.1 Sequence problems. AB016888 Genomic DNA Translation: BAB10481.1 Sequence problems. CP002688 Genomic DNA No translation available. AK221587 mRNA Translation: BAD95095.1 AF408061 mRNA Translation: AAL01112.1 |
RefSeqi | NP_001318731.1, NM_001344444.1 NP_001330664.1, NM_001344445.1 NP_001330665.1, NM_001344446.1 NP_001330666.1, NM_001344449.1 NP_001330667.1, NM_001344450.1 NP_001330668.1, NM_001344447.1 NP_001330669.1, NM_001344448.1 NP_001330670.1, NM_001344451.1 |
Genome annotation databases
GeneIDi | 834246 |
KEGGi | ath:AT5G42400 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU014691 mRNA Translation: ABV68922.1 Sequence problems. AB016888 Genomic DNA Translation: BAB10481.1 Sequence problems. CP002688 Genomic DNA No translation available. AK221587 mRNA Translation: BAD95095.1 AF408061 mRNA Translation: AAL01112.1 |
RefSeqi | NP_001318731.1, NM_001344444.1 NP_001330664.1, NM_001344445.1 NP_001330665.1, NM_001344446.1 NP_001330666.1, NM_001344449.1 NP_001330667.1, NM_001344450.1 NP_001330668.1, NM_001344447.1 NP_001330669.1, NM_001344448.1 NP_001330670.1, NM_001344451.1 |
3D structure databases
SMRi | F4K1J4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 3702.AT5G42400.1 |
Proteomic databases
PaxDbi | F4K1J4 |
PRIDEi | F4K1J4 |
ProteomicsDBi | 240925 |
Genome annotation databases
GeneIDi | 834246 |
KEGGi | ath:AT5G42400 |
Organism-specific databases
Araporti | AT5G42400 |
TAIRi | locus:2162346, AT5G42400 |
Phylogenomic databases
eggNOGi | KOG1080, Eukaryota |
HOGENOMi | CLU_003563_0_0_1 |
InParanoidi | F4K1J4 |
OrthoDBi | 875190at2759 |
Miscellaneous databases
PROi | PR:F4K1J4 |
Gene expression databases
ExpressionAtlasi | F4K1J4, baseline and differential |
Genevisiblei | F4K1J4, AT |
Family and domain databases
Gene3Di | 3.30.1490.40, 2 hits |
InterProi | View protein in InterPro IPR003169, GYF IPR035445, GYF-like_dom_sf IPR044570, Set1-like IPR001214, SET_dom |
PANTHERi | PTHR45814, PTHR45814, 1 hit |
Pfami | View protein in Pfam PF00856, SET, 1 hit |
SMARTi | View protein in SMART SM00317, SET, 1 hit |
SUPFAMi | SSF55277, SSF55277, 2 hits |
PROSITEi | View protein in PROSITE PS50829, GYF, 1 hit PS50280, SET, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATXR7_ARATH | |
Accessioni | F4K1J4Primary (citable) accession number: F4K1J4 Secondary accession number(s): A9QA58 Q9FIH7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2015 |
Last sequence update: | June 28, 2011 | |
Last modified: | April 7, 2021 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families