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Entry version 63 (29 Sep 2021)
Sequence version 1 (28 Jun 2011)
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Protein

Rho GTPase-activating protein 2

Gene

ROPGAP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 2
Alternative name(s):
Rho-type GTPase-activating protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ROPGAP2
Ordered Locus Names:At4g03100
ORF Names:F4C21.2, T4I9.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G03100

The Arabidopsis Information Resource

More...
TAIRi
locus:2139330, AT4G03100

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi88H → A: Reduces binding affinity with ARAC3/ROP7 10-fold. 1 Publication1
Mutagenesisi91H → A: Reduces binding affinity with ARAC3/ROP7 10-fold. 1 Publication1
Mutagenesisi165R → A: No effect on homodimerization and complex formation. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004227171 – 430Rho GTPase-activating protein 2Add BLAST430

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F4JI46

PRoteomics IDEntifications database

More...
PRIDEi
F4JI46

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
236167

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
F4JI46

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F4JI46, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
F4JI46, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimerizes via its Rho-GAP domain and forms a tetrameric complex (2:2) with ARAC1/ROP3, ARAC2/ROP7, ARAC4/ROP2, ARAC5/ROP4, ARAC7/ROP9 or ARAC11/ROP1.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
13383, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT4G03100.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F4JI46

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini80 – 93CRIBPROSITE-ProRule annotationAdd BLAST14
Domaini125 – 310Rho-GAPPROSITE-ProRule annotationAdd BLAST186

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 36DisorderedSequence analysisAdd BLAST36
Regioni307 – 372DisorderedSequence analysisAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi311 – 344Polar residuesSequence analysisAdd BLAST34
Compositional biasi358 – 372Basic and acidic residuesSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4270, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_031591_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F4JI46

Identification of Orthologs from Complete Genome Data

More...
OMAi
MDRSCEM

Database of Orthologous Groups

More...
OrthoDBi
1093913at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
3.90.810.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000095, CRIB_dom
IPR036936, CRIB_dom_sf
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
IPR044785, RopGAP1-5

The PANTHER Classification System

More...
PANTHERi
PTHR23177, PTHR23177, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00786, PBD, 1 hit
PF00620, RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00285, PBD, 1 hit
SM00324, RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50108, CRIB, 1 hit
PS50238, RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F4JI46-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGLVMMTKG GGCGGGGKGG RRKSTAEEEE EEEQNQQQLS LVEFLLTALR
60 70 80 90 100
KSVVSCRVDN RQDDGGVGGG ISSAVHHMEI GWPTNVRHIT HVTFDRFHGF
110 120 130 140 150
LGLPHELQVE IPCRVPSASV SVFGVSAESM QCSYDEKGNS VPTILLLMQE
160 170 180 190 200
RLYSQQGLKA EGIFRINPEN SQEEHVRDQL NRGIVPENID VHCLAGLIKA
210 220 230 240 250
WFRELPSGVL DGLSPEEVLN CNTEDESVEL IKQLKPTESA LLNWAVDLMA
260 270 280 290 300
DVVEEEESNK MNARNIAMVF APNMTQMTDP LTALMHAVQV MNLLKTLITK
310 320 330 340 350
TLAEREENAT GSEGYSPSHS SNSQTDSDSD NAQDMEVSCE SQATDSECGE
360 370 380 390 400
EEEVEEVEQH QEHLSRHSTH EDETDIGSLC SIEKCFLNQL NNNAARVSNT
410 420 430
SISEDWSPKA FPLVSFTENK SNTLSSSTSD
Length:430
Mass (Da):47,299
Last modified:June 28, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i870152C85E46FB97
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC79102 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAD14438 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAB77795 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti120 – 122VSV → FSF in BX826644 (PubMed:14993207).Curated3
Sequence conflicti427S → R in BX826644 (PubMed:14993207).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC005275 Genomic DNA Translation: AAD14438.1 Different initiation.
AF069442 Genomic DNA Translation: AAC79102.1 Different initiation.
AL161496 Genomic DNA Translation: CAB77795.1 Different initiation.
CP002687 Genomic DNA Translation: AEE82271.1
BX826644 mRNA No translation available.

Protein sequence database of the Protein Information Resource

More...
PIRi
T01383

NCBI Reference Sequences

More...
RefSeqi
NP_192219.2, NM_116544.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G03100.1; AT4G03100.1; AT4G03100

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
828092

Gramene; a comparative resource for plants

More...
Gramenei
AT4G03100.1; AT4G03100.1; AT4G03100

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G03100

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005275 Genomic DNA Translation: AAD14438.1 Different initiation.
AF069442 Genomic DNA Translation: AAC79102.1 Different initiation.
AL161496 Genomic DNA Translation: CAB77795.1 Different initiation.
CP002687 Genomic DNA Translation: AEE82271.1
BX826644 mRNA No translation available.
PIRiT01383
RefSeqiNP_192219.2, NM_116544.4

3D structure databases

SMRiF4JI46
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi13383, 1 interactor
STRINGi3702.AT4G03100.1

PTM databases

iPTMnetiF4JI46

Proteomic databases

PaxDbiF4JI46
PRIDEiF4JI46
ProteomicsDBi236167

Genome annotation databases

EnsemblPlantsiAT4G03100.1; AT4G03100.1; AT4G03100
GeneIDi828092
GrameneiAT4G03100.1; AT4G03100.1; AT4G03100
KEGGiath:AT4G03100

Organism-specific databases

AraportiAT4G03100
TAIRilocus:2139330, AT4G03100

Phylogenomic databases

eggNOGiKOG4270, Eukaryota
HOGENOMiCLU_031591_0_1_1
InParanoidiF4JI46
OMAiMDRSCEM
OrthoDBi1093913at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:F4JI46

Gene expression databases

ExpressionAtlasiF4JI46, baseline and differential
GenevisibleiF4JI46, AT

Family and domain databases

Gene3Di1.10.555.10, 1 hit
3.90.810.10, 1 hit
InterProiView protein in InterPro
IPR000095, CRIB_dom
IPR036936, CRIB_dom_sf
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
IPR044785, RopGAP1-5
PANTHERiPTHR23177, PTHR23177, 1 hit
PfamiView protein in Pfam
PF00786, PBD, 1 hit
PF00620, RhoGAP, 1 hit
SMARTiView protein in SMART
SM00285, PBD, 1 hit
SM00324, RhoGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50108, CRIB, 1 hit
PS50238, RHOGAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGAP2_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F4JI46
Secondary accession number(s): Q9ZNR7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2013
Last sequence update: June 28, 2011
Last modified: September 29, 2021
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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