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Entry version 70 (31 Jul 2019)
Sequence version 1 (28 Jun 2011)
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Protein

Protein PHOX1

Gene

PHOX1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Carboxylate clamp type tetratricopeptide repeat protein that may act as a potential Hsp90/Hsp70 co-chaperone (PubMed:20856808). Contributes to polar growth of root hairs (PubMed:28096376).1 Publication1 Publication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein PHOX11 Publication
Alternative name(s):
Protein MADB11 Publication
Putative myosin adapter B11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PHOX11 Publication
Synonyms:MADB11 Publication
Ordered Locus Names:At2g25290Imported
ORF Names:T22F11.12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G25290

The Arabidopsis Information Resource

More...
TAIRi
locus:2059546 AT2G25290

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No clumped-chloroplasts phenotype (PubMed:22025705). 31% reduction in root hair growth (PubMed:28096376). Phox1 and phox4 double mutants show no clumped-chloroplasts phenotype, but a 46% reduction in root hair growth (PubMed:22025705, PubMed:28096376). Phox1, phox3 and phox4 triple mutants and phox1, phox2, phox3 and phox4 quadruple mutants show a 70% reduction in root hair growth (PubMed:28096376).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004400191 – 745Protein PHOX1Add BLAST745

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F4IRM4

PRoteomics IDEntifications database

More...
PRIDEi
F4IRM4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
F4IRM4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F4IRM4 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with myosin XI-1 and XI-K.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT2G25290.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F4IRM4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati52 – 85TPR 1PROSITE-ProRule annotationAdd BLAST34
Repeati90 – 125TPR 2Sequence analysisAdd BLAST36
Repeati126 – 159TPR 3PROSITE-ProRule annotationAdd BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini280 – 359PB1PROSITE-ProRule annotationAdd BLAST80
Repeati406 – 441TPR 4Sequence analysisAdd BLAST36
Repeati443 – 472TPR 5Sequence analysisAdd BLAST30
Repeati494 – 528TPR 6Sequence analysisAdd BLAST35
Repeati553 – 586TPR 7Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi208 – 212Poly-LysSequence analysis5

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4151 Eukaryota
ENOG410XQNT LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000242704

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F4IRM4

Identification of Orthologs from Complete Genome Data

More...
OMAi
VFITMSQ

Database of Orthologous Groups

More...
OrthoDBi
260600at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000270 PB1_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00564 PB1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00666 PB1, 1 hit
SM00028 TPR, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51745 PB1, 1 hit
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F4IRM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKPTGKKKN NNYTEMPPTE SSTTGGGKTG KSFDRSATKS FDDDMTIFIN
60 70 80 90 100
RALELKEEGN KLFQKRDYEG AMFRYDKAVK LLPRDHGDVA YLRTSMASCY
110 120 130 140 150
MQMGLGEYPN AINECNLALE ASPRFSKALL KRARCYEALN KLDFAFRDSR
160 170 180 190 200
VVLNMEPENV SANEIFERVK KVLVGKGIDV DEMEKNLVNV QPVGAARLRK
210 220 230 240 250
IVKERLRKKK KKSMTMTNGG NDGERKSVEA VVEDAKVDNG EEVDSGRKGK
260 270 280 290 300
AIEEKKLEDK VAVMDKEVIA SEIKEDATVT RTVKLVHGDD IRWAQLPLDS
310 320 330 340 350
SVVLVRDVIK DRFPALKGFL IKYRDSEGDL VTITTTDELR LAASTREKLG
360 370 380 390 400
SFRLYIAEVS PNQEPTYDVI DNDESTDKFA KGSSSVADNG SVGDFVESEK
410 420 430 440 450
ASTSLEHWIF QFAQLFKNHV GFDSDSYLEL HNLGMKLYTE AMEDIVTGED
460 470 480 490 500
AQELFDIAAD KFQEMAALAM FNWGNVHMSK ARRQIYFPED GSRETILEKV
510 520 530 540 550
EAGFEWAKNE YNKAAEKYEG AVKIKSDFYE ALLALGQQQF EQAKLCWYHA
560 570 580 590 600
LSGEVDIESD ASQDVLKLYN KAEESMEKGM QIWEEMEERR LNGISNFDKH
610 620 630 640 650
KELLQKLGLD GIFSEASDEE SAEQTANMSS QINLLWGSLL YERSIVEYKL
660 670 680 690 700
GLPTWDECLE VAVEKFELAG ASATDIAVMV KNHCSSDNAL EGMGFKIDEI
710 720 730 740
VQAWNEMYDA KRWQIGVPSF RLEPLFRRRS PKLHDILENV FSGPQ
Length:745
Mass (Da):84,222
Last modified:June 28, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7E7C9FF79797286
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD23662 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC007070 Genomic DNA Translation: AAD23662.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC07680.1
CP002685 Genomic DNA Translation: AEC07681.1
CP002685 Genomic DNA Translation: AEC07682.1
CP002685 Genomic DNA Translation: ANM61435.1

Protein sequence database of the Protein Information Resource

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PIRi
F84646

NCBI Reference Sequences

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RefSeqi
NP_001154534.1, NM_001161062.2
NP_001189599.1, NM_001202670.1
NP_001323652.1, NM_001335984.1
NP_180101.4, NM_128086.6

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G25290.1; AT2G25290.1; AT2G25290
AT2G25290.2; AT2G25290.2; AT2G25290
AT2G25290.3; AT2G25290.3; AT2G25290
AT2G25290.4; AT2G25290.4; AT2G25290

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
817067

Gramene; a comparative resource for plants

More...
Gramenei
AT2G25290.1; AT2G25290.1; AT2G25290
AT2G25290.2; AT2G25290.2; AT2G25290
AT2G25290.3; AT2G25290.3; AT2G25290
AT2G25290.4; AT2G25290.4; AT2G25290

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G25290

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007070 Genomic DNA Translation: AAD23662.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC07680.1
CP002685 Genomic DNA Translation: AEC07681.1
CP002685 Genomic DNA Translation: AEC07682.1
CP002685 Genomic DNA Translation: ANM61435.1
PIRiF84646
RefSeqiNP_001154534.1, NM_001161062.2
NP_001189599.1, NM_001202670.1
NP_001323652.1, NM_001335984.1
NP_180101.4, NM_128086.6

3D structure databases

SMRiF4IRM4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G25290.2

PTM databases

iPTMnetiF4IRM4

Proteomic databases

PaxDbiF4IRM4
PRIDEiF4IRM4

Genome annotation databases

EnsemblPlantsiAT2G25290.1; AT2G25290.1; AT2G25290
AT2G25290.2; AT2G25290.2; AT2G25290
AT2G25290.3; AT2G25290.3; AT2G25290
AT2G25290.4; AT2G25290.4; AT2G25290
GeneIDi817067
GrameneiAT2G25290.1; AT2G25290.1; AT2G25290
AT2G25290.2; AT2G25290.2; AT2G25290
AT2G25290.3; AT2G25290.3; AT2G25290
AT2G25290.4; AT2G25290.4; AT2G25290
KEGGiath:AT2G25290

Organism-specific databases

AraportiAT2G25290
TAIRilocus:2059546 AT2G25290

Phylogenomic databases

eggNOGiKOG4151 Eukaryota
ENOG410XQNT LUCA
HOGENOMiHOG000242704
InParanoidiF4IRM4
OMAiVFITMSQ
OrthoDBi260600at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:F4IRM4

Gene expression databases

ExpressionAtlasiF4IRM4 baseline and differential

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR000270 PB1_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00564 PB1, 1 hit
SMARTiView protein in SMART
SM00666 PB1, 1 hit
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHOX1_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F4IRM4
Secondary accession number(s): Q9SIR4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2017
Last sequence update: June 28, 2011
Last modified: July 31, 2019
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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