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Entry version 59 (16 Jan 2019)
Sequence version 1 (28 Jun 2011)
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Protein

Chromatin structure-remodeling complex protein SYD

Gene

SYD

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls stem cell fate via the transcription regulation of WUS in the shoot apical meristem, by modulating its promoter. LFY-dependent repressor of the meristem identity switch from vegetative to reproductive development probably by modulating chromatin state. Involved in the regulation of floral homeotic gene expression in response to environmental stimuli. Required for carpel and ovule development, and for cotyledon separation via the regulation of CUC2 transcription. Regulates the promoters of several genes downstream of the jasmonate (JA) and ethylene (ET) signaling pathways. Required for resistance against the necrotrophic pathogen B.cinerea but not the biotrophic pathogen P.syringae.7 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi779 – 786ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity Source: TAIR
  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: UniProtKB-KW
  • helicase activity Source: UniProtKB-KW
  • histone binding Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processEthylene signaling pathway, Jasmonic acid signaling pathway, Plant defense, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromatin structure-remodeling complex protein SYD (EC:3.6.4.-)
Alternative name(s):
ATP-dependent helicase SYD
Protein CHROMATIN REMODELING 3
Protein SPLAYED
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYD
Synonyms:CHR3
Ordered Locus Names:At2g28290
ORF Names:T3B23
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G28290

The Arabidopsis Information Resource

More...
TAIRi
locus:2062840 AT2G28290

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Precocious transition from inflorescence to flower formation and impaired maintenance of the shoot apical meristem (SAM) during the reproductive phase. Abnormal flowers with splayed open first-whorl sepals due to outward bending of the pointy sepal tips. Reduced male fertility and reduced anther dehiscence. Partially unfused at the tip fourth-whorl carpels, with stigmatic tissue missing or placed internal to the carpel tip, leading to funnel shaped carpels. Female sterility ovule growth arrest at megagametogenesis. Fused cotyledons. Impaired expression of PDF1.2a, leading to reduced ethylene (ET) and jasmonic acid (JA) signaling. Reduced resistance toward B. cinerea.6 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1153G → E in syd-1; precocious transition from inflorescence to flower formation, abnormal flowers exhibiting variable petals and stamens number and position as well as some mosaic organs (stamenoid petals). 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004219361 – 3574Chromatin structure-remodeling complex protein SYDAdd BLAST3574

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F4IHS2

PRoteomics IDEntifications database

More...
PRIDEi
F4IHS2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
F4IHS2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mostly expressed in rapidly dividing cells in the vegetative, inflorescence, and root meristems, as well as in young leaf and flower primordia. Isoform 1 is predominantly found in seedlings whereas isoform 2 is present in both seedlings and inflorescences (at protein level).2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By wounding.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F4IHS2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
F4IHS2 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LFY (PubMed:22323601). Binds to BARD1/ROW1 (PubMed:18591352).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
2725, 33 interactors

Database of interacting proteins

More...
DIPi
DIP-60019N

Protein interaction database and analysis system

More...
IntActi
F4IHS2, 2 interactors

STRING: functional protein association networks

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STRINGi
3702.AT2G28290.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
F4IHS2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F4IHS2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini573 – 647HSAPROSITE-ProRule annotationAdd BLAST75
Domaini766 – 933Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST168
Domaini1077 – 1223Helicase C-terminalPROSITE-ProRule annotationAdd BLAST147

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi884 – 887DEAH box4
Motifi1266 – 1273Nuclear localization signalBy similarity8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0386 Eukaryota
KOG1181 Eukaryota
COG0553 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000176878

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F4IHS2

Database of Orthologous Groups

More...
OrthoDBi
685477at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00079 HELICc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR014978 Gln-Leu-Gln_QLQ
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR027417 P-loop_NTPase
IPR029295 SnAC
IPR038718 SNF2-like_sf
IPR000330 SNF2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00271 Helicase_C, 1 hit
PF14619 SnAC, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00951 QLQ, 1 hit
SM01314 SnAC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: F4IHS2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSSSHNIEL EAAKFLHKLI QDSKDEPAKL ATKLYVILQH MKTSGKENTM
60 70 80 90 100
PYQVISRAMD TVVNQHGLDI EALKSSCLPH PGGTQTEDSG SAHLAGSSQA
110 120 130 140 150
VGVSNEGKAT LVENEMTKYD AFTSGRQLGG SNSASQTFYQ GSGTQSNRSF
160 170 180 190 200
DRESPSNLDS TSGISQPHNR SETMNQRDVK SSGKRKRGES SLSWDQNMDN
210 220 230 240 250
SQIFDSHKID DQTGEVSKIE MPGNSGDIRN LHVGLSSDAF TTPQCGWQSS
260 270 280 290 300
EATAIRPAIH KEPGNNVAGE GFLPSGSPFR EQQLKQLRAQ CLVFLALRNG
310 320 330 340 350
LVPKKLHVEI ALRNTFREED GFRGELFDPK GRTHTSSDLG GIPDVSALLS
360 370 380 390 400
RTDNPTGRLD EMDFSSKETE RSRLGEKSFA NTVFSDGQKL LASRIPSSQA
410 420 430 440 450
QTQVAVSHSQ LTFSPGLTKN TPSEMVGWTG VIKTNDLSTS AVQLDEFHSS
460 470 480 490 500
DEEEGNLQPS PKYTMSQKWI MGRQNKRLLV DRSWSLKQQK ADQAIGSRFN
510 520 530 540 550
ELKESVSLSD DISAKTKSVI ELKKLQLLNL QRRLRSEFVY NFFKPIATDV
560 570 580 590 600
EHLKSYKKHK HGRRIKQLEK YEQKMKEERQ RRIRERQKEF FGGLEVHKEK
610 620 630 640 650
LEDLFKVRRE RLKGFNRYAK EFHKRKERLH REKIDKIQRE KINLLKINDV
660 670 680 690 700
EGYLRMVQDA KSDRVKQLLK ETEKYLQKLG SKLKEAKLLT SRFENEADET
710 720 730 740 750
RTSNATDDET LIENEDESDQ AKHYLESNEK YYLMAHSIKE NINEQPSSLV
760 770 780 790 800
GGKLREYQMN GLRWLVSLYN NHLNGILADE MGLGKTVQVI SLICYLMETK
810 820 830 840 850
NDRGPFLVVV PSSVLPGWQS EINFWAPSIH KIVYCGTPDE RRKLFKEQIV
860 870 880 890 900
HQKFNVLLTT YEYLMNKHDR PKLSKIHWHY IIIDEGHRIK NASCKLNADL
910 920 930 940 950
KHYVSSHRLL LTGTPLQNNL EELWALLNFL LPNIFNSSED FSQWFNKPFQ
960 970 980 990 1000
SNGESSAEEA LLSEEENLLI INRLHQVLRP FVLRRLKHKV ENELPEKIER
1010 1020 1030 1040 1050
LIRCEASAYQ KLLMKRVEDN LGSIGNAKSR AVHNSVMELR NICNHPYLSQ
1060 1070 1080 1090 1100
LHSEEVNNII PKHFLPPIVR LCGKLEMLDR MLPKLKATDH RVLFFSTMTR
1110 1120 1130 1140 1150
LLDVMEDYLT LKGYKYLRLD GQTSGGDRGA LIDGFNKSGS PFFIFLLSIR
1160 1170 1180 1190 1200
AGGVGVNLQA ADTVILFDTD WNPQVDLQAQ ARAHRIGQKK DVLVLRFETV
1210 1220 1230 1240 1250
NSVEEQVRAS AEHKLGVANQ SITAGFFDNN TSAEDRKEYL ESLLRESKKE
1260 1270 1280 1290 1300
EDAPVLDDDA LNDLIARRES EIDIFESIDK QRKENEMETW NTLVHGPGSD
1310 1320 1330 1340 1350
SFAHIPSIPS RLVTEDDLKL LYETMKLNDV PMVAKESTVG MKRKDGSMGG
1360 1370 1380 1390 1400
LDTHQYGRGK RAREVRSYEE KLTEEEFEKL CQTESPDSPQ GKGEGSERSL
1410 1420 1430 1440 1450
ANDTSNIPVE NSSDTLLPTS PTQAITVQPM EPVRPQSHTL KEETQPIKRG
1460 1470 1480 1490 1500
RGRPKRTDKA LTPVSLSAVS RTQATGNAIS SAATGLDFVS SDKRLEAASH
1510 1520 1530 1540 1550
PTSSLALTSP DLSGPPGFQS LPASPAPTPI RGRGRGRSRG RGAGRGRRVE
1560 1570 1580 1590 1600
GVLHGSNSSI TQRTETATSL ASDAEATKFA LPRSASEIVS RVPKANEGST
1610 1620 1630 1640 1650
SNPDQVSPVH SATTALRSDK AADKDLDAPP GFDSGSHVQT LNVLENSSER
1660 1670 1680 1690 1700
KAFAVKKRPL IQGVSSQHPG PNKQPLDLPV STSSTLLGGG PVQNQNAVSS
1710 1720 1730 1740 1750
VCDGSKSPSE GRTYTALQGV TTAPSDATLP MSSQPSDATL PMSSQPVGST
1760 1770 1780 1790 1800
VEAQEANVPS LPAALPAKRR VRNLPSRGET PKRQGKRRGQ PLPATDASSA
1810 1820 1830 1840 1850
RSTGLTPQIE VKVGNLSGTK AKFDAVAKEQ PHFSQSVAPD IHSSGSLSQE
1860 1870 1880 1890 1900
IRRDTSGTGG SARKQTADVT DVARVMKEIF SETSLLKHKV GEPSATTRTN
1910 1920 1930 1940 1950
VPDAQSPGEM NLHTVETHKA EDSSGLKNQE ALYNLSKADK LVSDIPHPVP
1960 1970 1980 1990 2000
GDLTTSGSVA NKDVDIGSSK VAAENELVKI PGGDVDSSVI QLSLGNTLTA
2010 2020 2030 2040 2050
KSSLEKCTAD QLLGEKLSQE GETTPASDGE TCHLAEETAS SLSYVRSEPT
2060 2070 2080 2090 2100
ASASTTAEPL PTDKLEKNIS FQDEVKTLNG DKREAILLSS EEQTNVNSKI
2110 2120 2130 2140 2150
ETNSEELQAS RTDEVPHVDG KSVDVANQTV KEDEAKHSVE IQSSMLEPDE
2160 2170 2180 2190 2200
LPNAGQKGHS SIDLQPLVLV TSNENAMSLD DKDYDPISKS ADIEQDPEES
2210 2220 2230 2240 2250
VFVQGVGRPK VGTADTQMED TNDAKLLVGC SVESEEKEKT LQSLIPGDDA
2260 2270 2280 2290 2300
DTEQDPEESV SDQRPKVGSA YTQMEDTDEA KLLMGCSVES EEKEKTLQSH
2310 2320 2330 2340 2350
IPGDDADTEK NPEESVSVQG VDRPKVGTTD TQMEDTNDAK LLVGCSVASE
2360 2370 2380 2390 2400
EKEKTLQSHI PGDDADTEQN PEESVSVQGV NRPKVGNANT QMEDTDEAKV
2410 2420 2430 2440 2450
LVGCSVESEE KEKTLQSHIP GDDADTEQNP EESVSNFDRP KDGTADTHME
2460 2470 2480 2490 2500
DIDDAKLLVG CSVESEEKEK SLQSHMPSDD AVLHAPFENT KDSKGDDLHG
2510 2520 2530 2540 2550
ESLVSCPTME VMEQKGFESE THARTDSGGI DRGNEVSENM SDGVKMNISS
2560 2570 2580 2590 2600
VQVPDASHDL NVSQDQTDIP LVGGIDPEHV QENVDVPASP HGAAPNIVIF
2610 2620 2630 2640 2650
QSEGHLSPSI LPDDVAGQLE SMSNDEKTNI SSEQVPDVSH DLKVSQDQTD
2660 2670 2680 2690 2700
IPPVGGIVPE NLQEIVDVPA SPHGVVPDVV VSQSEEIQSP SILPDDVPGQ
2710 2720 2730 2740 2750
PDDGNCEKMD TMQNNTSIDI GITSGKTCQP SSSTQPEDEN RNSLSHCEPS
2760 2770 2780 2790 2800
EVVEQRDSRD QVCIGSVESQ VEISSAILEN RSADIQPPQS ILVDQKDIEE
2810 2820 2830 2840 2850
SKEPGIESAD VSLHQLADIQ AEPSNLVDQM DIEESKEPGT ESADVSLHQL
2860 2870 2880 2890 2900
ADIQPGPSIL VDQMDTEKSK EPGTESADVS LHQLADIQPG PSILVDQMDT
2910 2920 2930 2940 2950
EKSKEPGTES ADVSLHQLAD IQPGPSILVD QMDTEEFKNP DVSLHQLADI
2960 2970 2980 2990 3000
EPSLSISAVQ KNIEDKDQSH VETAGSELVD VSAECSTEPQ VQLPPSSEPV
3010 3020 3030 3040 3050
GDMHVHLGAS KSEIVAEGTD FSSSLPKTEE ENAKSQLADT EPSSSLTAVQ
3060 3070 3080 3090 3100
KNIEDQVETA GCEFVVVSTG CSTEPQVQLP PSAEPVVAEG TEFPSSLLMT
3110 3120 3130 3140 3150
GVDNSSHLMT GVDNAKTHLA DVVPSSSPTT MEKNIEAQDQ DQVTTGGCGL
3160 3170 3180 3190 3200
VDVLTECSSE PQLQLPPSAE PVISEGTELA TLPLTEEENA DSQLANIEPS
3210 3220 3230 3240 3250
SSPSVVEKNI EAQDQDQVKT AGCELVSTGC SSEPQVHLPP SAEPDGDIHV
3260 3270 3280 3290 3300
HLKETEKSES MVVVGEGTAF PSSLPVTEEG NAESQLADTE PFTSPTVVEK
3310 3320 3330 3340 3350
NIKDQEQVET TGCGLVDDST GCSSEPQVQL PPSAEPMEGT HMHLEETKKS
3360 3370 3380 3390 3400
ETVVTEIQLA DIDPSFSLIV VQTNIEDQDQ IETGGCDLIN VPSGCSTEPQ
3410 3420 3430 3440 3450
IQLSSSAEPE EGMHIHLEAA MNSETVVTEG SELPSSLPMT EDENADGQLA
3460 3470 3480 3490 3500
EVEPSVSLTV EQTNIEEKDH IETAECELVD VSPGCSSQPE VKFPPSPDAV
3510 3520 3530 3540 3550
GGMDVHLETV VTEDTDSNSS LPKTEEKDAE NPSDRLDGES DGTTVATVEG
3560 3570
TCVESNSLVA EESNIEVPKD NEDV
Length:3,574
Mass (Da):389,864
Last modified:June 28, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i14209D18F717A69B
GO
Isoform 2 (identifier: F4IHS2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3339-3369: Missing.

Show »
Length:3,543
Mass (Da):386,412
Checksum:i4AB1EA362BF5EE77
GO
Isoform 3 (identifier: F4IHS2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3339-3383: Missing.

Note: No experimental confirmation available.
Show »
Length:3,529
Mass (Da):384,799
Checksum:i62B3C80A263A266D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8B2Y3A0A1P8B2Y3_ARATH
P-loop containing nucleoside tripho...
SYD CHR3, SPLAYED, At2g28290
3,544Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A178VTI3A0A178VTI3_ARATH
P-loop containing nucleoside tripho...
SYD CHR3, SPLAYED, At2g28290
3,575Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD29835 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAM66026 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti757Y → E in AAK31908 (PubMed:11818058).Curated1
Sequence conflicti757Y → E in AAX22009 (PubMed:16640604).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0462493339 – 3383Missing in isoform 3. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_0462503339 – 3369Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF247809 mRNA Translation: AAK31908.1
AY927849 mRNA Translation: AAX22009.1
AC006202 Genomic DNA Translation: AAD29835.2 Sequence problems.
CP002685 Genomic DNA Translation: AEC08099.1
CP002685 Genomic DNA Translation: AEC08100.1
CP002685 Genomic DNA Translation: AEC08101.1
CP002685 Genomic DNA Translation: ANM63245.1
AY088490 mRNA Translation: AAM66026.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...
PIRi
A84683

NCBI Reference Sequences

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RefSeqi
NP_001077971.1, NM_001084502.2 [F4IHS2-2]
NP_001325347.1, NM_001336158.1 [F4IHS2-2]
NP_850116.1, NM_179785.3 [F4IHS2-1]
NP_850117.1, NM_179786.2 [F4IHS2-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
At.22414

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G28290.1; AT2G28290.1; AT2G28290 [F4IHS2-1]
AT2G28290.2; AT2G28290.2; AT2G28290 [F4IHS2-3]
AT2G28290.3; AT2G28290.3; AT2G28290 [F4IHS2-2]
AT2G28290.4; AT2G28290.4; AT2G28290 [F4IHS2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
817375

Gramene; a comparative resource for plants

More...
Gramenei
AT2G28290.1; AT2G28290.1; AT2G28290 [F4IHS2-1]
AT2G28290.2; AT2G28290.2; AT2G28290 [F4IHS2-3]
AT2G28290.3; AT2G28290.3; AT2G28290 [F4IHS2-2]
AT2G28290.4; AT2G28290.4; AT2G28290 [F4IHS2-2]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G28290

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247809 mRNA Translation: AAK31908.1
AY927849 mRNA Translation: AAX22009.1
AC006202 Genomic DNA Translation: AAD29835.2 Sequence problems.
CP002685 Genomic DNA Translation: AEC08099.1
CP002685 Genomic DNA Translation: AEC08100.1
CP002685 Genomic DNA Translation: AEC08101.1
CP002685 Genomic DNA Translation: ANM63245.1
AY088490 mRNA Translation: AAM66026.1 Different initiation.
PIRiA84683
RefSeqiNP_001077971.1, NM_001084502.2 [F4IHS2-2]
NP_001325347.1, NM_001336158.1 [F4IHS2-2]
NP_850116.1, NM_179785.3 [F4IHS2-1]
NP_850117.1, NM_179786.2 [F4IHS2-3]
UniGeneiAt.22414

3D structure databases

ProteinModelPortaliF4IHS2
SMRiF4IHS2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi2725, 33 interactors
DIPiDIP-60019N
IntActiF4IHS2, 2 interactors
STRINGi3702.AT2G28290.1

PTM databases

iPTMnetiF4IHS2

Proteomic databases

PaxDbiF4IHS2
PRIDEiF4IHS2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G28290.1; AT2G28290.1; AT2G28290 [F4IHS2-1]
AT2G28290.2; AT2G28290.2; AT2G28290 [F4IHS2-3]
AT2G28290.3; AT2G28290.3; AT2G28290 [F4IHS2-2]
AT2G28290.4; AT2G28290.4; AT2G28290 [F4IHS2-2]
GeneIDi817375
GrameneiAT2G28290.1; AT2G28290.1; AT2G28290 [F4IHS2-1]
AT2G28290.2; AT2G28290.2; AT2G28290 [F4IHS2-3]
AT2G28290.3; AT2G28290.3; AT2G28290 [F4IHS2-2]
AT2G28290.4; AT2G28290.4; AT2G28290 [F4IHS2-2]
KEGGiath:AT2G28290

Organism-specific databases

AraportiAT2G28290
TAIRilocus:2062840 AT2G28290

Phylogenomic databases

eggNOGiKOG0386 Eukaryota
KOG1181 Eukaryota
COG0553 LUCA
HOGENOMiHOG000176878
InParanoidiF4IHS2
OrthoDBi685477at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:F4IHS2

Gene expression databases

ExpressionAtlasiF4IHS2 baseline and differential
GenevisibleiF4IHS2 AT

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR014978 Gln-Leu-Gln_QLQ
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR027417 P-loop_NTPase
IPR029295 SnAC
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF14619 SnAC, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00951 QLQ, 1 hit
SM01314 SnAC, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYD_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F4IHS2
Secondary accession number(s): F4IHS3
, F4IHS4, Q5BN47, Q8L9D7, Q9AUB4, Q9SL27
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2013
Last sequence update: June 28, 2011
Last modified: January 16, 2019
This is version 59 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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