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UniProtKB - F4I248 (CSCLB_ARATH)

Entry version 64 (23 Feb 2022)
Sequence version 1 (28 Jun 2011)
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Protein

CSC1-like protein At1g69450

Gene

At1g69450

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an osmosensitive calcium-permeable cation channel.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CSC1-like protein At1g69450
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:At1g69450
ORF Names:F10D13_27
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...Araporti		AT1G69450

The Arabidopsis Information Resource

More...TAIRi		locus:2007126, AT1G69450

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Transmembranei488 – 510HelicalSequence analysisAdd BLAST23
Transmembranei553 – 573HelicalSequence analysisAdd BLAST21
Transmembranei595 – 615HelicalSequence analysisAdd BLAST21
Transmembranei620 – 640HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004298091 – 711CSC1-like protein At1g69450Add BLAST711

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		F4I248

PRoteomics IDEntifications database

More...PRIDEi		F4I248

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		220493

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		F4I248, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		F4I248, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		3702.AT1G69450.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		F4I248

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CSC1 (TC 1.A.17) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1134, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002458_7_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		F4I248

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR045122, Csc1-like
IPR032880, Csc1_N
IPR027815, PHM7_cyt
IPR003864, RSN1_7TM

The PANTHER Classification System

More...PANTHERi		PTHR13018, PTHR13018, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14703, PHM7_cyt, 1 hit
PF02714, RSN1_7TM, 1 hit
PF13967, RSN1_TM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F4I248-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLSALLMSV GINSCLCVLL FILYSVLRKQ PRNYEVFLPR RLANGTYKRR 
        60         70         80         90        100
RNKVARYIPS LKWIWKSWRP TEKELMESSG LDGVVFMRMI TFSLKVFLFA 
       110        120        130        140        150
GIIGVFVLLP VNCFGDQLTV IDYADWSANS LDLFSVANLK VRSQWLWVHF 
       160        170        180        190        200
GAIYLVTVFV CCLLYFEFRY IALKRIEHFY SSKPKPEQFT ILVRNIPSSD 
       210        220        230        240        250
GSSVSDTVDR FFGENHSSTY FSHVVIHRTS KLRSVVDKAK KLYKEVKHKK 
       260        270        280        290        300
PVKKTPMRFF SRKDNTEGHY ESVLQEMEQN IRLGQAEVSA PGKEVRAAFV 
       310        320        330        340        350
SFKSRYGAAT ALHMPQSINP TYWLTEPAPE PHDVHWPFFS ASFMQKWLAK 
       360        370        380        390        400
ILVVFACLLL TILFLVPVVL VQGLTNLPAL EFMFPFLSLI LSMKVVSQII 
       410        420        430        440        450
TGYLPSLILQ TSLKVVPPTM EFLSSIQGHI CHSDIQKSAC NKVIWFTIWN 
       460        470        480        490        500
VFFATVFSGS AFYKLSVILD PKQIPLKLAV AVPAQASFFI AYVVTTGWTD 
       510        520        530        540        550
TLTELFRVVP FMVSYIKRSF EPSDENEFVV PPMRYHRDTP RVLFFGLLGI 
       560        570        580        590        600
TYFFLAPLIL PFILLYFILA YIIYRNQFMN VYAPKFDTGG MFWPMIHYTM 
       610        620        630        640        650
IFSLVLMQAI AIGLFALKKM ELATYLLVPL PVFTLLFNEF CRKRFMPIFT 
       660        670        680        690        700
DYPAEVLTKR DKEDRNDPTM PEFYNNLVSA YKDPALLPLR FSGSGSRNDS 
       710 
LTSPLLSFSE V
Length:711
Mass (Da):81,790
Last modified:June 28, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iADC70C48A97580B5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8AP05A0A1P8AP05_ARATH
Early-responsive to dehydration str...
At1g69450, F10D13.27, F10D13_27
738Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG60099 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC073178 Genomic DNA Translation: AAG60099.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE34926.1
CP002684 Genomic DNA Translation: AEE34927.1
BX814798 mRNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_001185356.1, NM_001198427.2
NP_177104.2, NM_105612.2

Genome annotation databases

Ensembl plant genome annotation project

More...EnsemblPlantsi		AT1G69450.1; AT1G69450.1; AT1G69450
AT1G69450.2; AT1G69450.2; AT1G69450

Database of genes from NCBI RefSeq genomes

More...GeneIDi		843277

Gramene; a comparative resource for plants

More...Gramenei		AT1G69450.1; AT1G69450.1; AT1G69450
AT1G69450.2; AT1G69450.2; AT1G69450

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ath:AT1G69450

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073178 Genomic DNA Translation: AAG60099.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE34926.1
CP002684 Genomic DNA Translation: AEE34927.1
BX814798 mRNA No translation available.
RefSeqiNP_001185356.1, NM_001198427.2
NP_177104.2, NM_105612.2

3D structure databases

SMRiF4I248
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G69450.2

Proteomic databases

PaxDbiF4I248
PRIDEiF4I248
ProteomicsDBi220493

Genome annotation databases

EnsemblPlantsiAT1G69450.1; AT1G69450.1; AT1G69450
AT1G69450.2; AT1G69450.2; AT1G69450
GeneIDi843277
GrameneiAT1G69450.1; AT1G69450.1; AT1G69450
AT1G69450.2; AT1G69450.2; AT1G69450
KEGGiath:AT1G69450

Organism-specific databases

AraportiAT1G69450
TAIRilocus:2007126, AT1G69450

Phylogenomic databases

eggNOGiKOG1134, Eukaryota
HOGENOMiCLU_002458_7_1_1
InParanoidiF4I248

Miscellaneous databases

Protein Ontology

More...PROi		PR:F4I248

Gene expression databases

ExpressionAtlasiF4I248, baseline and differential
GenevisibleiF4I248, AT

Family and domain databases

InterProiView protein in InterPro
IPR045122, Csc1-like
IPR032880, Csc1_N
IPR027815, PHM7_cyt
IPR003864, RSN1_7TM
PANTHERiPTHR13018, PTHR13018, 1 hit
PfamiView protein in Pfam
PF14703, PHM7_cyt, 1 hit
PF02714, RSN1_7TM, 1 hit
PF13967, RSN1_TM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSCLB_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F4I248
Secondary accession number(s): Q9C792
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: June 28, 2011
Last modified: February 23, 2022
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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