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Entry version 63 (16 Oct 2019)
Sequence version 1 (28 Jun 2011)
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Protein

DNA polymerase epsilon catalytic subunit A

Gene

POL2A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA polymerase II, which participates in chromosomal DNA replication. Required for the timing and determination of cell fate during plant embryogenesis and root pole development, by promoting cell cycle and cell type patterning. Necessary for proper shoot (SAM) and root apical meristem (RAM) functions. Involved in maintaining epigenetic states, controlling hypersensitive response (HR), and mediating abscisic acid (ABA) signaling. Required for flowering repression through a mechanism involving epigenetic gene silencing. May participate in processes involved in chromatin-mediated cellular memory.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi2038ZincBy similarity1
Metal bindingi2041ZincBy similarity1
Metal bindingi2063ZincBy similarity1
Metal bindingi2068ZincBy similarity1
Metal bindingi2099Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi2102Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi2114Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi2116Iron-sulfur (4Fe-4S)By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri2038 – 2068CysA-typeBy similarityAdd BLAST31

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA replication
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase epsilon catalytic subunit A (EC:2.7.7.7By similarity)
Alternative name(s):
DNA polymerase 2 a
Short name:
AtPOL2a
DNA polymerase II subunit a
Protein ABA OVERLY SENSITIVE a
Protein EARLY IN SHORT DAYS 7
Protein EMBRYO DEFECTIVE 142
Protein EMBRYO DEFECTIVE 2284
Protein EMBRYO DEFECTIVE 529
Protein TILTED 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POL2A
Synonyms:ABO4, EMB142, EMB2284, EMB529, ESD7, TIL1
Ordered Locus Names:At1g08260
ORF Names:T23G18.21
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G08260

The Arabidopsis Information Resource

More...
TAIRi
locus:2199973 AT1G08260

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Lethal, with sporophytic embryo-defective with an arrest at the globular stage during embryo development. Abnormal cell division characterized by several rounds of mitosis with aberrant planes of division.3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi469G → R in til1-4; lengthening of the cell cycle during embryo development and alters cell type patterning of the hypophyseal lineage in the root, leading to a displacement of the root pole from its normal position on top of the suspensor. Slow growing roots, slightly delayed flowering, altered floral phyllotaxis, a reduced number of ovules, abnormally developing ovules, and reduced fertility. 1 Publication1
Mutagenesisi992G → R in esd7-1; early flowering independently of photoperiod, shortened inflorescence internodes and altered flowers, leaves and roots development. Enrichement in acetylated H3 and trimethylated H3 'Lys-4' (H3K4me3) activating epigenetic marks of the chromatin of FT and AG loci. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004202401 – 2161DNA polymerase epsilon catalytic subunit AAdd BLAST2161

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F4HW04

PRoteomics IDEntifications database

More...
PRIDEi
F4HW04

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mostly expressed at low levels in inflorescence (floral meristem and flowers until anthesis), and, to a lower extent, in roots, seeds and leaves.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Present in actively dividing cells such as root and shoot meristematic regions, young leaves and stems, inflorescences and siliques.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Follows a cell-cycle-dependent expression with a maximal induction in the S phase and another induction at the G2/M transition.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F4HW04 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
F4HW04 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer (By similarity). Subunit of the DNA polymerase II (PubMed:16212602, PubMed:19947980).

Interacts (via C-terminus) with DPB2 (PubMed:16212602).

Interacts with LHP1/TFL2 (PubMed:19947980).

By similarity2 Publications

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT1G08260.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F4HW04

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi5 – 12Nuclear localization signal 1By similarity8
Motifi1137 – 1144Nuclear localization signal 2By similarity8
Motifi1239 – 1246Nuclear localization signal 3By similarity8
Motifi2099 – 2116CysB motifBy similarityAdd BLAST18
Motifi2130 – 2137Nuclear localization signal 4By similarity8

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DNA polymerase activity domain resides in the N-terminal half of the protein, while the C-terminus is necessary for maintenance of the complex.By similarity
The CysA-type zinc finger is required for PCNA-binding.By similarity
The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-B family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2038 – 2068CysA-typeBy similarityAdd BLAST31

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1798 Eukaryota
COG0417 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F4HW04

KEGG Orthology (KO)

More...
KOi
K02324

Identification of Orthologs from Complete Genome Data

More...
OMAi
VYDLDMK

Database of Orthologous Groups

More...
OrthoDBi
39650at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.132.60, 1 hit
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR042087 DNA_pol_B_C
IPR013697 DNA_pol_e_suA_C
IPR029703 POL2
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10670 PTHR10670, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 1 hit
PF08490 DUF1744, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01159 DUF1744, 1 hit
SM00486 POLBc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098 SSF53098, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F4HW04-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGDNRRRDR KDTRWSKKPK VVNTAEDELE SKLGFGLFSE GETRLGWLLT
60 70 80 90 100
FSSSSWEDRD TGKVYSCVDL YFVTQDGFSF KTKYKFRPYF YAATKDKMEL
110 120 130 140 150
ELEAYLRRRY ERQVADIEIV EKEDLDLKNH LSGLQKKYLK ISFDTVQQLM
160 170 180 190 200
EVKRDLLHIV ERNQAKFDAL EAYESILAGK REQRPQDCLD SIVDLREYDV
210 220 230 240 250
PYHVRFAIDN DVRSGQWYNV SISSTDVILE KRTDLLQRAE VRVCAFDIET
260 270 280 290 300
TKLPLKFPDA EYDQIMMISY MVDGQGFLII NRECVGEDVE DLEYTPKPEF
310 320 330 340 350
EGYFKVTNVK NEVELLQRWF YHMQELKPGI YVTYNGDFFD WPFIERRASH
360 370 380 390 400
HGIKMNEELG FRCDQNQGEC RAKFACHLDC FAWVKRDSYL PQGSHGLKAV
410 420 430 440 450
TKAKLGYDPL EVNPEDMVRF AMEKPQTMAS YSVSDAVATY YLYMTYVNPF
460 470 480 490 500
IFSLATIIPM VPDEVLRKGS GTLCEMLLMV EAYKANVVCP NKNQADPEKF
510 520 530 540 550
YQNQLLESET YIGGHVECLE SGVFRSDIPT SFKLDSSAYQ QLIDNLGRDL
560 570 580 590 600
EYAITVEGKM RMDSISNYDE VKDEIKEKLE KLRDDPIREE GPLIYHLDVA
610 620 630 640 650
AMYPNIILTN RLQPPSIVTD EICTACDFNR PGKTCLRKLE WVWRGVTFMG
660 670 680 690 700
KKSDYYHLKK QIESEFVDAG ANIMSSKSFL DLPKVDQQSK LKERLKKYCQ
710 720 730 740 750
KAYKRVLDKP ITEVREAGIC MRENPFYVDT VRSFRDRRYE YKTLNKVWKG
760 770 780 790 800
KLSEAKASGN SIKIQEAQDM VVVYDSLQLA HKCILNSFYG YVMRKGARWY
810 820 830 840 850
SMEMAGVVTY TGAKIIQNAR LLIERIGKPL ELDTDGIWCC LPGSFPENFT
860 870 880 890 900
FKTIDMKKLT ISYPCVMLNV DVAKNNTNDQ YQTLVDPVRK TYKSHSECSI
910 920 930 940 950
EFEVDGPYKA MIIPASKEEG ILIKKRYAVF NHDGTLAELK GFEIKRRGEL
960 970 980 990 1000
KLIKVFQAEL FDKFLHGSTL EECYSAVAAV ADRWLDLLDN QGKDIADSEL
1010 1020 1030 1040 1050
LDYISESSTM SKSLADYGEQ KSCAVTTAKR LAEFLGVTMV KDKGLRCQYI
1060 1070 1080 1090 1100
VACEPKGTPV SERAVPVAIF TTNPEVMKFH LRKWCKTSSD VGIRLIIDWS
1110 1120 1130 1140 1150
YYKQRLSSAI QKVITIPAAM QKVANPVPRV LHPDWLHKKV REKDDKFRQR
1160 1170 1180 1190 1200
KLVDMFSSAN KDVVLDTDLP VTKDNVEDIE DFCKENRPSV KGPKPIARSY
1210 1220 1230 1240 1250
EVNKKQSECE QQESWDTEFH DISFQNIDKS VNYQGWLELK KRKWKVTLEK
1260 1270 1280 1290 1300
KKKRRLGDLR SSNQVDTHEI NQKVGQGRGG VGSYFRRPEE ALTSSHWQII
1310 1320 1330 1340 1350
QLVPSPQSGQ FFAWVVVEGL MLKIPLSIPR VFYINSKVPI DEYFQGKCVN
1360 1370 1380 1390 1400
KILPHGRPCY SLTEVKIQED QFKKESKKRA ALLADPGVEG IYETKVPLEF
1410 1420 1430 1440 1450
SAICQIGCVC KIDNKAKHRN TQDGWEVGEL HMKTTTECHY LKRSIPLVYL
1460 1470 1480 1490 1500
YNSTSTGRAI YVLYCHVSKL MSAVVVDPFN GNELLPSALE RQFRDSCLEL
1510 1520 1530 1540 1550
SLDSLSWDGI RFQVHYVDHP EAAKKIIQRA ISEYREENCG PTVAVIECPD
1560 1570 1580 1590 1600
FTFMKEGIKA LDDFPCVRIP FNDDDNSYQP VSWQRPAAKI AMFRCAAAFQ
1610 1620 1630 1640 1650
WLDRRITQSR YAHVPLGNFG LDWLTFTIDI FLSRALRDQQ QVLWVSDNGV
1660 1670 1680 1690 1700
PDLGGINNEE AFFADEVQQT SLVFPGAYRK VSVELKIHNL AVNALLKSNL
1710 1720 1730 1740 1750
VNEMEGGGFM GFEQDVNPRG INSNDNTSFD ETTGCAQAFR VLKQLIHSCL
1760 1770 1780 1790 1800
TDVRKSKNIY ADSILQRLSW WLCSPSSKLH DPALHLMLHK VMQKVFALLL
1810 1820 1830 1840 1850
TDLRRLGAII IYADFSKVII DTVKFDLSAA KAYCESLLST VRNSDIFEWI
1860 1870 1880 1890 1900
LLEPVHYWHS LLFMDQYNYA GIRADDEISL DEVTIEPKWS VARHLPEYIE
1910 1920 1930 1940 1950
RDFIIIIAKF IFDPWKFAIE NKKGSSESLE AQMIEYLREQ IGSTFINMLV
1960 1970 1980 1990 2000
KKVDDIMSHM KEINVSDASR VSGQAPKGDY SLEFIQVISA VLALDQNVQQ
2010 2020 2030 2040 2050
DVLVMRKSLL KYIKVKECAA EAEFLDPGPS FILPNVACSN CDAYRDLDIC
2060 2070 2080 2090 2100
RDPALLTEKE WSCADTQCGK IYDREQMESS LLEMVRQRER MYHMQDVVCI
2110 2120 2130 2140 2150
RCNQVKAAHL TEQCECSGSF RCKESGSEFS KRMEIFMDIA KRQKFRLLEE
2160
YISWIIYGPS Y
Length:2,161
Mass (Da):248,897
Last modified:June 28, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D17C1600609CD2B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A178WI12A0A178WI12_ARATH
DNA polymerase epsilon catalytic su...
TIL1 ABA OVERLY SENSITIVE 4, ABO4, EARLY IN SHORT DAYS 7, EMB142, EMB2284
2,114Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF18240 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC011438 Genomic DNA Translation: AAF18240.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28266.1

NCBI Reference Sequences

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RefSeqi
NP_172303.5, NM_100699.6

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G08260.1; AT1G08260.1; AT1G08260

Database of genes from NCBI RefSeq genomes

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GeneIDi
837346

Gramene; a comparative resource for plants

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Gramenei
AT1G08260.1; AT1G08260.1; AT1G08260

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT1G08260

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011438 Genomic DNA Translation: AAF18240.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28266.1
RefSeqiNP_172303.5, NM_100699.6

3D structure databases

SMRiF4HW04
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G08260.1

Proteomic databases

PaxDbiF4HW04
PRIDEiF4HW04

Genome annotation databases

EnsemblPlantsiAT1G08260.1; AT1G08260.1; AT1G08260
GeneIDi837346
GrameneiAT1G08260.1; AT1G08260.1; AT1G08260
KEGGiath:AT1G08260

Organism-specific databases

AraportiAT1G08260
TAIRilocus:2199973 AT1G08260

Phylogenomic databases

eggNOGiKOG1798 Eukaryota
COG0417 LUCA
InParanoidiF4HW04
KOiK02324
OMAiVYDLDMK
OrthoDBi39650at2759

Miscellaneous databases

Protein Ontology

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PROi
PR:F4HW04

Gene expression databases

ExpressionAtlasiF4HW04 baseline and differential
GenevisibleiF4HW04 AT

Family and domain databases

Gene3Di1.10.132.60, 1 hit
3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR042087 DNA_pol_B_C
IPR013697 DNA_pol_e_suA_C
IPR029703 POL2
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR10670 PTHR10670, 1 hit
PfamiView protein in Pfam
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 1 hit
PF08490 DUF1744, 1 hit
SMARTiView protein in SMART
SM01159 DUF1744, 1 hit
SM00486 POLBc, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPOE1_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F4HW04
Secondary accession number(s): B3H4I0, Q9SGD5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2012
Last sequence update: June 28, 2011
Last modified: October 16, 2019
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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