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Entry version 67 (13 Feb 2019)
Sequence version 2 (12 Apr 2017)
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Protein

DNA polymerase

Gene

REV3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterUniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotation, DNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotation
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:REV3Imported
Synonyms:ATREV3Imported, recovery protein 3Imported
Ordered Locus Names:At1g67500Imported
ORF Names:T1F15.3Imported, T1F15_3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G67500

The Arabidopsis Information Resource

More...
TAIRi
locus:2008783 AT1G67500

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
F4HTM5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini55 – 211DNA_pol_B_exo1InterPro annotationAdd BLAST157
Domaini1056 – 1253DNA_pol_B_exo1InterPro annotationAdd BLAST198
Domaini1321 – 1768DNA_pol_BInterPro annotationAdd BLAST448
Domaini1814 – 1887zf-C4polInterPro annotationAdd BLAST74

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-B family.UniRule annotation

Keywords - Domaini

Zinc-fingerUniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0968 Eukaryota
COG0417 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F4HTM5

Database of Orthologous Groups

More...
OrthoDBi
20210at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.10, 1 hit
3.90.1600.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR023211 DNA_pol_palm_dom_sf
IPR030559 PolZ_Rev3
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR025687 Znf-C4pol

The PANTHER Classification System

More...
PANTHERi
PTHR10322:SF5 PTHR10322:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 2 hits
PF14260 zf-C4pol, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00106 DNAPOLB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00486 POLBc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098 SSF53098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

F4HTM5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADSQSGSNV FSLRIVSIDY YMASPIPGYN ICYSSFQGSE VNEVPVIRIY
60 70 80 90 100
GSTPAGQKTC LHIHRALPYL YIPCSEIPLE HHKGVDGSTL ALSLELEKAL
110 120 130 140 150
KLKGNAASKR QHIHDCEIVR AKKFYGYHST EEAFVKIYLY HPPDVARAAS
160 170 180 190 200
LLLAGAVLGK SLQPYESHIP FILQFLVDYN LYGMGHVHIS KMKFRSPVPH
210 220 230 240 250
HFRPRRFDLD DCPGQRIDEV AITKANSSAA ASVSFPVWSL STIPGQWMWN
260 270 280 290 300
LSEESDTPLS QSQHRHQHHY RRQSLCELEG DATSSGNFPD SKFNCLCFMY
310 320 330 340 350
DRTFELASSL VDILNQQFKM YNSLSQAQSD TNMVQSLVAI WEEEYERTGV
360 370 380 390 400
HDAPIPPDPG KPSAADVLQT MSDYVGFGNM LKEMLNKVEL SPPGMKPTAV
410 420 430 440 450
SSAGPDMHAK PEITDLQALN HMVGTCSEFP ASEQLSPLGE KSEEASMEND
460 470 480 490 500
EYMKTPTDRD TPAQIQDAEA LGLFKWFASS QAAEDINSDD EILRETILSP
510 520 530 540 550
LLPLASINKV LEMASTDYVS QSQKECQDIL DSQENLPDFG SSTKRALPSN
560 570 580 590 600
PDSQNLRTSS DKQSLEIEVA SDVPDSSTSN GASENSFRRY RKSDLHTSEV
610 620 630 640 650
MEYKNRSFSK SNKPSNSVWG PLPFTLTKNL QKDFDSTNAS DKLGLTKISS
660 670 680 690 700
YPMNEMTDNY IVPVKEHQAD VCNTIDRNVL AGCSLRDLMR KKRLCHGESP
710 720 730 740 750
VSQHMKSRKV RDSRHGEKNE CTLRCEAKKQ GPALSAEFSE FVCGDTPNLS
760 770 780 790 800
PIDSGNCECN ISTESSELHS VDRCSAKETA SQNSDEVLRN LSSTTVPFGK
810 820 830 840 850
DPQTVESGTL VSSNIHVGIE IDSVQKSGRE QESTANETDE TGRLICLTLS
860 870 880 890 900
KKPPSLDCLS AGLQDSAHSH EIHAREKQHD EYEGNSNDIP FFPLEDNKEE
910 920 930 940 950
KKHFFQGTSL GIPLHHLNDG SNLYLLTPAF SPPSVDSVLQ WISNDKGDSN
960 970 980 990 1000
IDSEKQPLRD NHNDRGASFT DLASASNVVS VSEHVEQHNN LFVNSESNAY
1010 1020 1030 1040 1050
TESEIDLKPK GTFLNLNLQA SVSQELSQIS GPDGKSGPTP LSQMGFRDPA
1060 1070 1080 1090 1100
SMGAGQQLTI LSIEVHAESR GDLRPDPRFD SVNVIALVVQ NDDSFVAEVF
1110 1120 1130 1140 1150
VLLFSPDSID QRNVDGLSGC KLSVFLEERQ LFRYFIETLC KWDPDVLLGW
1160 1170 1180 1190 1200
DIQGGSIGFL AERAAQLGIR FLNNISRTPS PTTTNNSDNK RKLGNNLLPD
1210 1220 1230 1240 1250
PLVANPAQVE EVVIEDEWGR THASGVHVGG RIVLNAWRLI RGEVKLNMYT
1260 1270 1280 1290 1300
IEAVSEAVLR QKVPSIPYKV LTEWFSSGPA GARYRCIEYV IRRANLNLEI
1310 1320 1330 1340 1350
MSQLDMINRT SELARVFGID FFSVLSRGSQ YRVESMLLRL AHTQNYLAIS
1360 1370 1380 1390 1400
PGNQQVASQP AMECVPLVME PESAFYDDPV IVLDFQSLYP SMIIAYNLCF
1410 1420 1430 1440 1450
STCLGKLAHL KMNTLGVSSY SLDLDVLQDL NQILQTPNSV MYVPPEVRRG
1460 1470 1480 1490 1500
ILPRLLEEIL STRIMVKKAM KKLTPSEAVL HRIFNARQLA LKLIANVTYG
1510 1520 1530 1540 1550
YTAAGFSGRM PCAELADSIV QCGRSTLEKA ISFVNANDNW NARVVYGDTD
1560 1570 1580 1590 1600
SMFVLLKGRT VKEAFVVGQE IASAITEMNP HPVTLKMEKV YHPCFLLTKK
1610 1620 1630 1640 1650
RYVGYSYESP NQREPIFDAK GIETVRRDTC EAVAKTMEQS LRLFFEQKNI
1660 1670 1680 1690 1700
SKVKSYLYRQ WKRILSGRVS LQDFIFAKEV RLGTYSTRDS SLLPPAAIVA
1710 1720 1730 1740 1750
TKSMKADPRT EPRYAERVPY VVIHGEPGAR LVDMVVDPLV LLDVDTPYRL
1760 1770 1780 1790 1800
NDLYYINKQI IPALQRVFGL VGADLNQWFL EMPRLTRSSL GQRPLNSKNS
1810 1820 1830 1840 1850
HKTRIDYFYL SKHCILCGEV VQESAQLCNR CLQNKSAAAA TIVWKTSKLE
1860 1870 1880 1890 1900
REMQHLATIC RHCGGGDWVV QSGVKCNSLA CSVFYERRKV QKELRGLSSI
1910
ATESELYPKC MAEWF
Length:1,915
Mass (Da):213,748
Last modified:April 12, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F997481922E264F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q766Z3REV3_ARATH
DNA polymerase zeta catalytic subun...
REV3 At1g67500, F12B7.5, T1F15.3
1,890Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1P8AMN7A0A1P8AMN7_ARATH
DNA polymerase
REV3 ATREV3, recovery protein 3, At1g67500, T1F15.3, T1F15_3
1,890Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1P8AMM8A0A1P8AMM8_ARATH
DNA polymerase
REV3 ATREV3, recovery protein 3, At1g67500, T1F15.3, T1F15_3
1,889Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1P8AMQ2A0A1P8AMQ2_ARATH
DNA polymerase
REV3 ATREV3, recovery protein 3, At1g67500, T1F15.3, T1F15_3
1,629Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP002684 Genomic DNA Translation: AEE34656.2
CP002684 Genomic DNA Translation: ANM57916.1

NCBI Reference Sequences

More...
RefSeqi
NP_001319333.1, NM_001334301.1
NP_001320392.1, NM_001334306.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
At.35644

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G67500.2; AT1G67500.2; AT1G67500
AT1G67500.7; AT1G67500.7; AT1G67500

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
843071

Gramene; a comparative resource for plants

More...
Gramenei
AT1G67500.2; AT1G67500.2; AT1G67500
AT1G67500.7; AT1G67500.7; AT1G67500

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002684 Genomic DNA Translation: AEE34656.2
CP002684 Genomic DNA Translation: ANM57916.1
RefSeqiNP_001319333.1, NM_001334301.1
NP_001320392.1, NM_001334306.1
UniGeneiAt.35644

3D structure databases

ProteinModelPortaliF4HTM5
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G67500.2; AT1G67500.2; AT1G67500
AT1G67500.7; AT1G67500.7; AT1G67500
GeneIDi843071
GrameneiAT1G67500.2; AT1G67500.2; AT1G67500
AT1G67500.7; AT1G67500.7; AT1G67500

Organism-specific databases

AraportiAT1G67500
TAIRilocus:2008783 AT1G67500

Phylogenomic databases

eggNOGiKOG0968 Eukaryota
COG0417 LUCA
InParanoidiF4HTM5
OrthoDBi20210at2759

Family and domain databases

Gene3Di3.30.420.10, 1 hit
3.90.1600.10, 1 hit
InterProiView protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR023211 DNA_pol_palm_dom_sf
IPR030559 PolZ_Rev3
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR025687 Znf-C4pol
PANTHERiPTHR10322:SF5 PTHR10322:SF5, 1 hit
PfamiView protein in Pfam
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 2 hits
PF14260 zf-C4pol, 1 hit
PRINTSiPR00106 DNAPOLB
SMARTiView protein in SMART
SM00486 POLBc, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF4HTM5_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F4HTM5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: April 12, 2017
Last modified: February 13, 2019
This is version 67 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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