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Protein

Tyrosine--tRNA ligase

Gene

tyrS

Organism
Pyrococcus sp. (strain NA2)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).UniRule annotation

Catalytic activityi

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37TyrosineUniRule annotation1
Binding sitei168TyrosineUniRule annotation1
Binding sitei172TyrosineUniRule annotation1
Binding sitei175TyrosineUniRule annotation1
Binding sitei190TyrosineUniRule annotation1
Binding sitei254ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciPSP342949:G1GX4-1586-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine--tRNA ligaseUniRule annotation (EC:6.1.1.1UniRule annotation)
Alternative name(s):
Tyrosyl-tRNA synthetaseUniRule annotation
Short name:
TyrRSUniRule annotation
Gene namesi
Name:tyrSUniRule annotation
Ordered Locus Names:PNA2_1536Imported
OrganismiPyrococcus sp. (strain NA2)Imported
Taxonomic identifieri342949 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000008293 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi342949.PNA2_1536

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi251 – 255"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01886 Archaea
COG0162 LUCA
KOiK01866
OMAiYIGFEIS
OrthoDBiPOG093Z05HU

Family and domain databases

Gene3Di3.40.50.620, 1 hit
HAMAPiMF_02009 Tyr_tRNA_synth_type4, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR023678 Tyr-tRNA-ligase_4
IPR023617 Tyr-tRNA-ligase_arc/euk-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PIRSFiPIRSF006588 TyrRS_arch_euk, 1 hit

Sequencei

Sequence statusi: Complete.

F4HJF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIEERVNLV MRKPTEEVLT VENLRHLFEV GAPLQHYIGF EISGYIHLGT
60 70 80 90 100
GLMAGAKIAD FQKAGIKTRV FLADWHSWIN DKLGGDLEVI QEVALKYFKV
110 120 130 140 150
GMEKSIEVMG GDPKKVEFVL ASEILENGDY WQTVIDISKN VTLSRVMRSI
160 170 180 190 200
TIMGRQMGES IDFAKLIYPM MQVADIFYQG VTIAHAGMDQ RKAHVIAIEV
210 220 230 240 250
AQKLRYHPII HKGEKLKPVA VHHHLLLGLQ EPPKWPIESE EEFKEIKAQM
260 270 280 290 300
KMSKSKPYSA VFIHDTPEEI REKLRKAFCP ARETRYNPVL DWVEYIIFRE
310 320 330 340 350
EPTEFTIHRP AKFGGDVTYT TFEELKKDFA EGKLHPLDLK NAVADYLIDL
360 370
LEPIRKYFEK HPEPLELMRS VKITR
Length:375
Mass (Da):43,271
Last modified:June 28, 2011 - v1
Checksum:iE16D560FA566AF8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002670 Genomic DNA Translation: AEC52450.1
RefSeqiWP_013749000.1, NC_015474.1

Genome annotation databases

EnsemblBacteriaiAEC52450; AEC52450; PNA2_1536
GeneIDi10555021
KEGGipyn:PNA2_1536
PATRICifig|342949.8.peg.1540

Similar proteinsi

Entry informationi

Entry nameiF4HJF4_PYRSN
AccessioniPrimary (citable) accession number: F4HJF4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: March 28, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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