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Protein

Trifunctional purine biosynthetic protein adenosine-3

Gene

ade3-RA

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation
ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase (ade2)
  2. Trifunctional purine biosynthetic protein adenosine-3 (ade3), Trifunctional purine biosynthetic protein adenosine-3 (Gart), Trifunctional purine biosynthetic protein adenosine-3 (ade3-RA)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Amidophosphoribosyltransferase (Prat), Amidophosphoribosyltransferase (Prat), Amidophosphoribosyltransferase (Prat2), Amidophosphoribosyltransferase (CG2867), Amidophosphoribosyltransferase (CG2867), Amidophosphoribosyltransferase (Prat2)
  2. Trifunctional purine biosynthetic protein adenosine-3 (ade3), Trifunctional purine biosynthetic protein adenosine-3 (Gart), Trifunctional purine biosynthetic protein adenosine-3 (ade3-RA)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Trifunctional purine biosynthetic protein adenosine-3 (ade3), Trifunctional purine biosynthetic protein adenosine-3 (Gart), Trifunctional purine biosynthetic protein adenosine-3 (ade3-RA)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation, Multifunctional enzymeUniRule annotation
Biological processPurine biosynthesisUniRule annotation
LigandATP-bindingPROSITE-ProRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00125
UPA00074; UER00126
UPA00074; UER00129

Names & Taxonomyi

Protein namesi
Recommended name:
Trifunctional purine biosynthetic protein adenosine-3UniRule annotation
Including the following 3 domains:
Phosphoribosylamine--glycine ligaseUniRule annotation (EC:6.3.4.13UniRule annotation)
Alternative name(s):
Glycinamide ribonucleotide synthetaseUniRule annotation
Short name:
GARSUniRule annotation
Phosphoribosylglycinamide synthetaseUniRule annotation
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
Short name:
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Phosphoribosylglycinamide formyltransferaseUniRule annotation (EC:2.1.2.2UniRule annotation)
Alternative name(s):
5'-phosphoribosylglycinamide transformylaseUniRule annotation
GAR transformylaseUniRule annotation
Short name:
GARTUniRule annotation
Gene namesi
Name:ade3-RAImported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Subcellular locationi

Expressioni

Gene expression databases

BgeeiFBgn0000053
ExpressionAtlasiF3YDH3 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 321ATP-graspInterPro annotationAdd BLAST208

Sequence similaritiesi

In the C-terminal section; belongs to the GART family.UniRule annotation
In the N-terminal section; belongs to the GARS family.UniRule annotation
In the central section; belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0237 Eukaryota
KOG3076 Eukaryota
COG0150 LUCA
COG0151 LUCA
COG0299 LUCA

Family and domain databases

CDDicd08645 FMT_core_GART, 1 hit
cd02196 PurM, 2 hits
Gene3Di3.30.1330.10, 2 hits
3.30.1490.20, 1 hit
3.90.600.10, 1 hit
3.90.650.10, 2 hits
HAMAPiMF_00741 AIRS, 1 hit
MF_00138 GARS, 1 hit
MF_01930 PurN, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR004607 GART
IPR001555 GART_AS
IPR016185 PreATP-grasp_dom_sf
IPR020561 PRibGlycinamid_synth_ATP-grasp
IPR000115 PRibGlycinamide_synth
IPR020560 PRibGlycinamide_synth_C-dom
IPR037123 PRibGlycinamide_synth_C_sf
IPR020559 PRibGlycinamide_synth_CS
IPR020562 PRibGlycinamide_synth_N
IPR010918 PurM-like_C_dom
IPR036676 PurM-like_C_sf
IPR016188 PurM-like_N
IPR036921 PurM-like_N_sf
IPR004733 PurM_cligase
IPR011054 Rudment_hybrid_motif
PANTHERiPTHR10520 PTHR10520, 2 hits
PfamiView protein in Pfam
PF00586 AIRS, 2 hits
PF02769 AIRS_C, 2 hits
PF00551 Formyl_trans_N, 1 hit
PF01071 GARS_A, 1 hit
PF02843 GARS_C, 1 hit
PF02844 GARS_N, 1 hit
SMARTiView protein in SMART
SM01210 GARS_C, 1 hit
SUPFAMiSSF51246 SSF51246, 1 hit
SSF52440 SSF52440, 1 hit
SSF53328 SSF53328, 1 hit
SSF55326 SSF55326, 2 hits
SSF56042 SSF56042, 2 hits
TIGRFAMsiTIGR00877 purD, 1 hit
TIGR00878 purM, 2 hits
TIGR00639 PurN, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00184 GARS, 1 hit
PS00373 GART, 1 hit

Sequencei

Sequence statusi: Complete.

F3YDH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHRVLVIGS GGREHAICWK LSQSPKVAQI YALPGSHGIQ LVEKCRNLDA
60 70 80 90 100
KTLDPKDFEA IAKWSKENQI ALVVVGPEDP LALGLGDVLQ SAGIPCFGPG
110 120 130 140 150
KQGAQIEADK KWAKDFMLRH GIPTARYESF TDTEKAKAFI RSAPYPALVV
160 170 180 190 200
KAAGLAAGKG VVVAANAKEA CQAVDEILGD LKYGQAGATL VVEELLEGEE
210 220 230 240 250
VSVLAFTDGK SVRAMLPAQD HKRLGNGDTG PNTGGMGAYC PCPLISQPAL
260 270 280 290 300
ELVQKAVLER AVQGLIKERI NYQGVLYAGL MLTRDGPRVL EFNCRFGDPE
310 320 330 340 350
TQVILPLLES DLFDVMEACC SGKLDKIPLQ WRNGVSAVGV ILASAGYPET
360 370 380 390 400
STKGCIISGL PAANTPTQLV FHSGLAVNAQ KEALTNGGRV LIAIALDGSL
410 420 430 440 450
KEAAAKATKL AGSISFSGSG AQYRTDIAQK AFKIASASTP GLSYKDSGVD
460 470 480 490 500
IDAGDALVQR IKPLSRGTQR PGVIGGLGGF GGLFRLKELT YKEPVIAEAT
510 520 530 540 550
QGVGAKIHLA LTHELYENVG YDLFALAAND VLEVGAEPVA FLDYIACGKL
560 570 580 590 600
QVPLAAQLVK GMADGCRDAR CALVGGETAE MPSLYAPGQH DMAGYCVGIV
610 620 630 640 650
EQSRILPRFD LYQPGDLLIG LPSSGLHCAG FNEILTQLAA SKVNLRERSP
660 670 680 690 700
VDGGDDGLTL AHVLATPTQL YVQQLLPHLQ KGDEIKSVAH VTHGLLNDIL
710 720 730 740 750
RLLPDGFETT LDFGAVPVPK IFGWLAGKLK LSAQTILERH NCGIGMVLIL
760 770 780 790 800
PQSSQLWRTS LPGAKVLGVL QRRSKVSGSP VQVRNFVEQL EKVASPFGGL
810 820 830 840 850
GDRKLPKELK KLPSNSDLSA PREECFENAA GRRLTRIPTH YKDPILILGT
860 870 880 890 900
DGVGTKLKIA QQTNRNTSVG IDLVAMCVNY ILCNGAEPIS FSSYYACGHW
910 920 930 940 950
QEQLAKEVHS GVQEGARQAN SSFIDSHSAA LPLLYEPQVY DLAGFALGIA
960 970 980 990 1000
EHTGILPLLD EIQPGDVLIG LPSSGVHSNG FSLVHAVLKR VGLGLHDKAP
1010 1020 1030 1040 1050
FSDKTLGEEL LVPTKIYVKA LSTLLSRGKH GIKALAHITG GGLSENIPRV
1060 1070 1080 1090 1100
LRKDLAVRLD ANKFQLPPVF AWLAAAGNIS STELQRTYNC GLGMVLVVAP
1110 1120 1130 1140 1150
TEVEDVLKEL RYPQRAAVVG EVVARKDPKK SQVVVQNFEA SLARTQKMLS
1160 1170 1180 1190 1200
QRRKRVAVLI SGTGSNLQAL IDATRDSAQG IHADVVLVIS NKTGVLGLQR
1210 1220 1230 1240 1250
ATQAGIPSLV ISHKDFASRE VYDAELTRNL KAARVDLICL AGFMRVLSAP
1260 1270 1280 1290 1300
FVREWRGRLV NIHPSLLPKY PGLHVQKQAL EAGEKESGCT VHFVDEGVDT
1310 1320 1330 1340 1350
GAIIVQAAVP ILPDDDEDSL TQRIHKAEHW AFPRALAMLV NGTALISPEV

SSQ
Length:1,353
Mass (Da):144,572
Last modified:June 28, 2011 - v1
Checksum:i1F416D4C952615B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT126334 mRNA Translation: AEB72014.1

Similar proteinsi

Entry informationi

Entry nameiF3YDH3_DROME
AccessioniPrimary (citable) accession number: F3YDH3
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: July 18, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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