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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Pseudomonas amygdali pv. lachrymans str. M302278
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotationSAAS annotation
  • pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: agmatine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes agmatine from L-arginine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Biosynthetic arginine decarboxylase (speA)
This subpathway is part of the pathway agmatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes agmatine from L-arginine, the pathway agmatine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotationSAAS annotation, Lyase
Biological processPolyamine biosynthesisUniRule annotationSAAS annotation, Spermidine biosynthesisUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotation, Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00186; UER00284

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
ORF Names:PLA106_02395Imported
OrganismiPseudomonas amygdali pv. lachrymans str. M302278Imported
Taxonomic identifieri629267 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas amygdali
Proteomesi
  • UP000005479 Componenti: Unassembled WGS sequence

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliF3ICR4
SMRiF3ICR4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 350Orn_Arg_deC_NInterPro annotationAdd BLAST253

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni290 – 300Substrate-bindingUniRule annotationAdd BLAST11

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili440 – 460Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

CDDicd06830 PLPDE_III_ADC, 1 hit
Gene3Di2.40.37.10, 3 hits
3.20.20.10, 1 hit
HAMAPiMF_01417 SpeA, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR002985 Arg_decrbxlase
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR000183 Orn/DAP/Arg_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR43295 PTHR43295, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PIRSFiPIRSF001336 Arg_decrbxlase, 1 hit
PRINTSiPR01180 ARGDCRBXLASE
PR01179 ODADCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR01273 speA, 1 hit
PROSITEiView protein in PROSITE
PS00879 ODR_DC_2_2, 1 hit

Sequencei

Sequence statusi: Complete.

F3ICR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRRTRKDD GSQWTVADSR SVYGIRHWGA GYFAINEAGR VEVRPNGPDS
60 70 80 90 100
SPIDLYEQVD NLRKSGLSLP LLVRFPDILQ DRVRQLTGAF DSNIARLEYQ
110 120 130 140 150
SQYTALYPIK VNQQEAVVEN IIATQNVSIG LEAGSKPELM AVLALAPKGG
160 170 180 190 200
TIVCNGYKDR EFIRLALMGQ KLGHNVFIVI EKESEVELVI EEAAELKVAP
210 220 230 240 250
QVGLRVRLSS LASSKWADTG GEKSKFGLSA AQLLSVVERF RKAGLDQGIR
260 270 280 290 300
LLHFHMGSQI ANLADYQHGF KEAIRYYGEL RKLGLPVDYI DVGGGLGVDY
310 320 330 340 350
DGTHSRNASS INYDMDDYAG VVVGMLKEFC DAQSLPHPHI FSESGRSLTA
360 370 380 390 400
HHAMLVVQVT DVEKHNDEVP KIADKESLPE TVQWLVDLLG PTDIEMVTET
410 420 430 440 450
YWRATHYMSD IATQYADGKI SLAEKALGEQ CYFAVCRRLY NSLKARQRSH
460 470 480 490 500
RQVLDELNDK LADKYICNFS VFQSLPDTWA IGQVLPILPL HRLDEEPVRR
510 520 530 540 550
AVLQDLTCDS DGKIKQYVDE QSIETSMPVH SLNEGEDYLL GIFLVGAYQE
560 570 580 590 600
ILGDMHNLFG DTDSVNIYQN PDGSVYHAGI ETHDTIEDML RYVHLSPEEL
610 620 630
MTHYRDKVAS AKITPRERTY FLDALRLGLT RSSYLSS
Length:637
Mass (Da):71,379
Last modified:June 28, 2011 - v1
Checksum:iF564FFEBD5494FCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEAM01000049 Genomic DNA Translation: EGH94776.1
RefSeqiWP_005763203.1, NZ_GL385193.1

Genome annotation databases

EnsemblBacteriaiEGH94776; EGH94776; PLA106_02395
PATRICifig|629267.3.peg.479

Similar proteinsi

Entry informationi

Entry nameiF3ICR4_PSEAV
AccessioniPrimary (citable) accession number: F3ICR4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: June 20, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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