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Entry version 74 (31 Jul 2019)
Sequence version 2 (22 Nov 2017)
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Protein

Ubiquitin-like domain-containing protein

Gene
N/A
Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SSC-110312 Translesion synthesis by REV1
R-SSC-110314 Recognition of DNA damage by PCNA-containing replication complex
R-SSC-110320 Translesion Synthesis by POLH
R-SSC-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-SSC-1253288 Downregulation of ERBB4 signaling
R-SSC-1295596 Spry regulation of FGF signaling
R-SSC-1358803 Downregulation of ERBB2:ERBB3 signaling
R-SSC-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SSC-168638 NOD1/2 Signaling Pathway
R-SSC-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-SSC-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-SSC-174154 APC/C:Cdc20 mediated degradation of Securin
R-SSC-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-SSC-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-SSC-179409 APC-Cdc20 mediated degradation of Nek2A
R-SSC-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SSC-182971 EGFR downregulation
R-SSC-187577 SCF(Skp2)-mediated degradation of p27/p21
R-SSC-195253 Degradation of beta-catenin by the destruction complex
R-SSC-201681 TCF dependent signaling in response to WNT
R-SSC-202424 Downstream TCR signaling
R-SSC-209543 p75NTR recruits signalling complexes
R-SSC-209560 NF-kB is activated and signals survival
R-SSC-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-SSC-2173788 Downregulation of TGF-beta receptor signaling
R-SSC-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-SSC-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-SSC-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-SSC-2467813 Separation of Sister Chromatids
R-SSC-2559580 Oxidative Stress Induced Senescence
R-SSC-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-SSC-2559585 Oncogene Induced Senescence
R-SSC-2672351 Stimuli-sensing channels
R-SSC-2871837 FCERI mediated NF-kB activation
R-SSC-3134975 Regulation of innate immune responses to cytosolic DNA
R-SSC-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-SSC-3769402 Deactivation of the beta-catenin transactivating complex
R-SSC-382556 ABC-family proteins mediated transport
R-SSC-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-SSC-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-SSC-4608870 Asymmetric localization of PCP proteins
R-SSC-4641257 Degradation of AXIN
R-SSC-4641258 Degradation of DVL
R-SSC-4641263 Regulation of FZD by ubiquitination
R-SSC-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-SSC-5357905 Regulation of TNFR1 signaling
R-SSC-5357956 TNFR1-induced NFkappaB signaling pathway
R-SSC-5358346 Hedgehog ligand biogenesis
R-SSC-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-SSC-5607764 CLEC7A (Dectin-1) signaling
R-SSC-5610780 Degradation of GLI1 by the proteasome
R-SSC-5610785 GLI3 is processed to GLI3R by the proteasome
R-SSC-5632684 Hedgehog 'on' state
R-SSC-5654726 Negative regulation of FGFR1 signaling
R-SSC-5654727 Negative regulation of FGFR2 signaling
R-SSC-5654732 Negative regulation of FGFR3 signaling
R-SSC-5654733 Negative regulation of FGFR4 signaling
R-SSC-5655862 Translesion synthesis by POLK
R-SSC-5656121 Translesion synthesis by POLI
R-SSC-5656169 Termination of translesion DNA synthesis
R-SSC-5658442 Regulation of RAS by GAPs
R-SSC-5668541 TNFR2 non-canonical NF-kB pathway
R-SSC-5675221 Negative regulation of MAPK pathway
R-SSC-5675482 Regulation of necroptotic cell death
R-SSC-5676590 NIK-->noncanonical NF-kB signaling
R-SSC-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-SSC-5685942 HDR through Homologous Recombination (HRR)
R-SSC-5687128 MAPK6/MAPK4 signaling
R-SSC-5689603 UCH proteinases
R-SSC-5689877 Josephin domain DUBs
R-SSC-5689880 Ub-specific processing proteases
R-SSC-5689896 Ovarian tumor domain proteases
R-SSC-5689901 Metalloprotease DUBs
R-SSC-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-SSC-5696394 DNA Damage Recognition in GG-NER
R-SSC-5696395 Formation of Incision Complex in GG-NER
R-SSC-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-SSC-5696400 Dual Incision in GG-NER
R-SSC-6781823 Formation of TC-NER Pre-Incision Complex
R-SSC-6782135 Dual incision in TC-NER
R-SSC-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-SSC-6783310 Fanconi Anemia Pathway
R-SSC-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-SSC-6804756 Regulation of TP53 Activity through Phosphorylation
R-SSC-6804757 Regulation of TP53 Degradation
R-SSC-6804760 Regulation of TP53 Activity through Methylation
R-SSC-6807004 Negative regulation of MET activity
R-SSC-68827 CDT1 association with the CDC6:ORC:origin complex
R-SSC-68949 Orc1 removal from chromatin
R-SSC-69017 CDK-mediated phosphorylation and removal of Cdc6
R-SSC-69231 Cyclin D associated events in G1
R-SSC-69481 G2/M Checkpoints
R-SSC-69541 Stabilization of p53
R-SSC-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SSC-72689 Formation of a pool of free 40S subunits
R-SSC-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SSC-75815 Ubiquitin-dependent degradation of Cyclin D
R-SSC-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
R-SSC-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-SSC-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-SSC-8856825 Cargo recognition for clathrin-mediated endocytosis
R-SSC-8856828 Clathrin-mediated endocytosis
R-SSC-8863795 Downregulation of ERBB2 signaling
R-SSC-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-SSC-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-SSC-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-SSC-8939902 Regulation of RUNX2 expression and activity
R-SSC-8941858 Regulation of RUNX3 expression and activity
R-SSC-8948747 Regulation of PTEN localization
R-SSC-8948751 Regulation of PTEN stability and activity
R-SSC-8951664 Neddylation
R-SSC-901032 ER Quality Control Compartment (ERQC)
R-SSC-9020702 Interleukin-1 signaling
R-SSC-9033241 Peroxisomal protein import
R-SSC-912631 Regulation of signaling by CBL
R-SSC-917729 Endosomal Sorting Complex Required For Transport (ESCRT)
R-SSC-917937 Iron uptake and transport
R-SSC-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-SSC-937039 IRAK1 recruits IKK complex
R-SSC-937041 IKK complex recruitment mediated by RIP1
R-SSC-937042 IRAK2 mediated activation of TAK1 complex
R-SSC-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-SSC-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-SSC-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-SSC-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
R-SSC-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SSC-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
R-SSC-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin-like domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F2Z5U0

PeptideAtlas

More...
PeptideAtlasi
F2Z5U0

PRoteomics IDEntifications database

More...
PRIDEi
F2Z5U0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSSSCG00000022357 Expressed in 5 organ(s), highest expression level in adult mammalian kidney

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
F2Z5U0 SS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 41Ubiquitin-likeInterPro annotationAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 43DisorderedSequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 22PolyampholyteSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0004 Eukaryota
COG5272 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00910000144152

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F2Z5U0

TreeFam database of animal gene trees

More...
TreeFami
TF300036

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.25.660, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002906 Ribosomal_S27a
IPR011332 Ribosomal_zn-bd
IPR038582 S27a-like_sf
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01599 Ribosomal_S27, 1 hit
PF00240 ubiquitin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01402 Ribosomal_S27, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54236 SSF54236, 1 hit
SSF57829 SSF57829, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F2Z5U0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SQVEPSDAIE KETTKTQEKA GIPPERQRPI FAGKQPEDGH TKESTLHLVV
60 70 80 90 100
RRREKEEVFH HSQKEQQRRK KVKLAVLKYD MGDENGKISP LPWQRPSGEC
110 120 130
GAGVFPASHF DRHYCGTYYL TYCFNKSEDK
Length:130
Mass (Da):15,015
Last modified:November 22, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43910E345E911D40
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AEMK02000021 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00000026044; ENSSSCP00000028049; ENSSSCG00000022357

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000021 Genomic DNA No translation available.

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Pelectron microscopy3.50Sf2-130[»]
3J7Relectron microscopy3.90Sf2-130[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Proteomic databases

PaxDbiF2Z5U0
PeptideAtlasiF2Z5U0
PRIDEiF2Z5U0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000026044; ENSSSCP00000028049; ENSSSCG00000022357

Phylogenomic databases

eggNOGiKOG0004 Eukaryota
COG5272 LUCA
GeneTreeiENSGT00910000144152
InParanoidiF2Z5U0
TreeFamiTF300036

Enzyme and pathway databases

ReactomeiR-SSC-110312 Translesion synthesis by REV1
R-SSC-110314 Recognition of DNA damage by PCNA-containing replication complex
R-SSC-110320 Translesion Synthesis by POLH
R-SSC-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-SSC-1253288 Downregulation of ERBB4 signaling
R-SSC-1295596 Spry regulation of FGF signaling
R-SSC-1358803 Downregulation of ERBB2:ERBB3 signaling
R-SSC-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SSC-168638 NOD1/2 Signaling Pathway
R-SSC-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-SSC-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-SSC-174154 APC/C:Cdc20 mediated degradation of Securin
R-SSC-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-SSC-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-SSC-179409 APC-Cdc20 mediated degradation of Nek2A
R-SSC-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SSC-182971 EGFR downregulation
R-SSC-187577 SCF(Skp2)-mediated degradation of p27/p21
R-SSC-195253 Degradation of beta-catenin by the destruction complex
R-SSC-201681 TCF dependent signaling in response to WNT
R-SSC-202424 Downstream TCR signaling
R-SSC-209543 p75NTR recruits signalling complexes
R-SSC-209560 NF-kB is activated and signals survival
R-SSC-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-SSC-2173788 Downregulation of TGF-beta receptor signaling
R-SSC-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-SSC-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-SSC-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-SSC-2467813 Separation of Sister Chromatids
R-SSC-2559580 Oxidative Stress Induced Senescence
R-SSC-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-SSC-2559585 Oncogene Induced Senescence
R-SSC-2672351 Stimuli-sensing channels
R-SSC-2871837 FCERI mediated NF-kB activation
R-SSC-3134975 Regulation of innate immune responses to cytosolic DNA
R-SSC-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-SSC-3769402 Deactivation of the beta-catenin transactivating complex
R-SSC-382556 ABC-family proteins mediated transport
R-SSC-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-SSC-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-SSC-4608870 Asymmetric localization of PCP proteins
R-SSC-4641257 Degradation of AXIN
R-SSC-4641258 Degradation of DVL
R-SSC-4641263 Regulation of FZD by ubiquitination
R-SSC-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-SSC-5357905 Regulation of TNFR1 signaling
R-SSC-5357956 TNFR1-induced NFkappaB signaling pathway
R-SSC-5358346 Hedgehog ligand biogenesis
R-SSC-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-SSC-5607764 CLEC7A (Dectin-1) signaling
R-SSC-5610780 Degradation of GLI1 by the proteasome
R-SSC-5610785 GLI3 is processed to GLI3R by the proteasome
R-SSC-5632684 Hedgehog 'on' state
R-SSC-5654726 Negative regulation of FGFR1 signaling
R-SSC-5654727 Negative regulation of FGFR2 signaling
R-SSC-5654732 Negative regulation of FGFR3 signaling
R-SSC-5654733 Negative regulation of FGFR4 signaling
R-SSC-5655862 Translesion synthesis by POLK
R-SSC-5656121 Translesion synthesis by POLI
R-SSC-5656169 Termination of translesion DNA synthesis
R-SSC-5658442 Regulation of RAS by GAPs
R-SSC-5668541 TNFR2 non-canonical NF-kB pathway
R-SSC-5675221 Negative regulation of MAPK pathway
R-SSC-5675482 Regulation of necroptotic cell death
R-SSC-5676590 NIK-->noncanonical NF-kB signaling
R-SSC-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-SSC-5685942 HDR through Homologous Recombination (HRR)
R-SSC-5687128 MAPK6/MAPK4 signaling
R-SSC-5689603 UCH proteinases
R-SSC-5689877 Josephin domain DUBs
R-SSC-5689880 Ub-specific processing proteases
R-SSC-5689896 Ovarian tumor domain proteases
R-SSC-5689901 Metalloprotease DUBs
R-SSC-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-SSC-5696394 DNA Damage Recognition in GG-NER
R-SSC-5696395 Formation of Incision Complex in GG-NER
R-SSC-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-SSC-5696400 Dual Incision in GG-NER
R-SSC-6781823 Formation of TC-NER Pre-Incision Complex
R-SSC-6782135 Dual incision in TC-NER
R-SSC-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-SSC-6783310 Fanconi Anemia Pathway
R-SSC-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-SSC-6804756 Regulation of TP53 Activity through Phosphorylation
R-SSC-6804757 Regulation of TP53 Degradation
R-SSC-6804760 Regulation of TP53 Activity through Methylation
R-SSC-6807004 Negative regulation of MET activity
R-SSC-68827 CDT1 association with the CDC6:ORC:origin complex
R-SSC-68949 Orc1 removal from chromatin
R-SSC-69017 CDK-mediated phosphorylation and removal of Cdc6
R-SSC-69231 Cyclin D associated events in G1
R-SSC-69481 G2/M Checkpoints
R-SSC-69541 Stabilization of p53
R-SSC-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SSC-72689 Formation of a pool of free 40S subunits
R-SSC-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SSC-75815 Ubiquitin-dependent degradation of Cyclin D
R-SSC-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
R-SSC-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-SSC-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-SSC-8856825 Cargo recognition for clathrin-mediated endocytosis
R-SSC-8856828 Clathrin-mediated endocytosis
R-SSC-8863795 Downregulation of ERBB2 signaling
R-SSC-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-SSC-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-SSC-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-SSC-8939902 Regulation of RUNX2 expression and activity
R-SSC-8941858 Regulation of RUNX3 expression and activity
R-SSC-8948747 Regulation of PTEN localization
R-SSC-8948751 Regulation of PTEN stability and activity
R-SSC-8951664 Neddylation
R-SSC-901032 ER Quality Control Compartment (ERQC)
R-SSC-9020702 Interleukin-1 signaling
R-SSC-9033241 Peroxisomal protein import
R-SSC-912631 Regulation of signaling by CBL
R-SSC-917729 Endosomal Sorting Complex Required For Transport (ESCRT)
R-SSC-917937 Iron uptake and transport
R-SSC-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-SSC-937039 IRAK1 recruits IKK complex
R-SSC-937041 IKK complex recruitment mediated by RIP1
R-SSC-937042 IRAK2 mediated activation of TAK1 complex
R-SSC-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-SSC-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-SSC-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-SSC-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
R-SSC-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SSC-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
R-SSC-983168 Antigen processing: Ubiquitination & Proteasome degradation

Gene expression databases

BgeeiENSSSCG00000022357 Expressed in 5 organ(s), highest expression level in adult mammalian kidney
GenevisibleiF2Z5U0 SS

Family and domain databases

Gene3Di2.20.25.660, 1 hit
InterProiView protein in InterPro
IPR002906 Ribosomal_S27a
IPR011332 Ribosomal_zn-bd
IPR038582 S27a-like_sf
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF01599 Ribosomal_S27, 1 hit
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM01402 Ribosomal_S27, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF57829 SSF57829, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF2Z5U0_PIG
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F2Z5U0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: November 22, 2017
Last modified: July 31, 2019
This is version 74 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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