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Entry version 61 (16 Oct 2019)
Sequence version 1 (31 May 2011)
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Protein
Submitted name:

A kinase (PRKA) anchor protein 12b

Gene

akap12b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
A kinase (PRKA) anchor protein 12bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:akap12bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-9753 akap12b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F2Z4T4

PRoteomics IDEntifications database

More...
PRIDEi
F2Z4T4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000055678 Expressed in 44 organ(s), highest expression level in multi-cellular organism

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F2Z4T4 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000103304

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini465 – 493WSKInterPro annotationAdd BLAST29
Domaini633 – 660WSKInterPro annotationAdd BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 64DisorderedSequence analysisAdd BLAST64
Regioni87 – 791DisorderedSequence analysisAdd BLAST705
Regioni822 – 842DisorderedSequence analysisAdd BLAST21
Regioni953 – 972DisorderedSequence analysisAdd BLAST20
Regioni1352 – 1376DisorderedSequence analysisAdd BLAST25
Regioni1449 – 1533DisorderedSequence analysisAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 18PolarSequence analysisAdd BLAST18
Compositional biasi19 – 64PolyampholyteSequence analysisAdd BLAST46
Compositional biasi105 – 151PolyampholyteSequence analysisAdd BLAST47
Compositional biasi161 – 188PolyampholyteSequence analysisAdd BLAST28
Compositional biasi194 – 210PolarSequence analysisAdd BLAST17
Compositional biasi221 – 281PolyampholyteSequence analysisAdd BLAST61
Compositional biasi282 – 296PolarSequence analysisAdd BLAST15
Compositional biasi297 – 318PolyampholyteSequence analysisAdd BLAST22
Compositional biasi319 – 338PolarSequence analysisAdd BLAST20
Compositional biasi339 – 353PolyampholyteSequence analysisAdd BLAST15
Compositional biasi403 – 427PolarSequence analysisAdd BLAST25
Compositional biasi455 – 469PolyampholyteSequence analysisAdd BLAST15
Compositional biasi482 – 497PolyampholyteSequence analysisAdd BLAST16
Compositional biasi510 – 564PolyampholyteSequence analysisAdd BLAST55
Compositional biasi642 – 662PolyampholyteSequence analysisAdd BLAST21
Compositional biasi669 – 683PolyampholyteSequence analysisAdd BLAST15
Compositional biasi738 – 768PolarSequence analysisAdd BLAST31
Compositional biasi1449 – 1472PolyampholyteSequence analysisAdd BLAST24

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFC9 Eukaryota
ENOG4110Y3C LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111244

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F2Z4T4

KEGG Orthology (KO)

More...
KOi
K16528

Database of Orthologous Groups

More...
OrthoDBi
620777at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028540 AKAP12
IPR001573 Pkinase-A_anch_WSK-motif

The PANTHER Classification System

More...
PANTHERi
PTHR23209 PTHR23209, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03832 WSK, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

F2Z4T4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGTITLTVG QTDTISPKED SPETIEVHQE EVAPQMNGEK GDDSANADEI
60 70 80 90 100
TTAEEKVVEE KQEEANEVGF KKIFRFVGFK FTLKKDKNEK TEPVQLLTVK
110 120 130 140 150
EAESGADAAT EEKKEEPAAE EDRSVEEKSP ETTENEAKAE EVTEKAEEPA
160 170 180 190 200
EQTVVDAPSE TEKVSDIETE KPAEETGTIS EKEPEPEVPA ESPTSPPSQE
210 220 230 240 250
TQSPFKRFFT QGIFSNLRKK ASFKKPKDEE HVKEKPVEED IKETEETAEG
260 270 280 290 300
VPEATEEAKV DAENEPAEGE QIEKPSETVE TKAETTTETT AETTNEVTPT
310 320 330 340 350
EKEEQQDLKV EAEATSEVET VTHTEPAQAP AVETTQPTDD AKTSDKPDIS
360 370 380 390 400
EEAPTEPEIL SSQEKSKAHG SPLKKLFTGA GLKKLSSKKH KNKKDAESKQ
410 420 430 440 450
TESSEQTAET VQSTESTEPQ KPDSGASSPE ESGEHVVGEV AQAEVAQAVE
460 470 480 490 500
PDGDAVTSDG EKKKEGILPW SSFKKLVTPK KRVKRPSESE DEAPGDKPKS
510 520 530 540 550
STLSSTESAI SDEKADEPKP SEEVPSKEEL KEEAKEESQA ESKTEPKAEK
560 570 580 590 600
SESVAEEPKR KMDTSVSWEA LICVGSSKKR ARKTSDSDDE EAKIEEEVQP
610 620 630 640 650
SEEEPIKTAE SPLVSSGEAD HENLASSPEP EGELVSTWES FKRLVTHRKK
660 670 680 690 700
AKAEDKSDEA SGPEQTTSDS ETPKEESSFS LRKLIPRRKK KSDGKQEQVS
710 720 730 740 750
SDVGSAEDDS DTPAVVPLSE YDSEPSAEAA VKAEEVKQES ATVTQAKASA
760 770 780 790 800
EDRSPSWIST TVENVEDETE GNQLSDIPEE GDTAATPKST DNTIAEDIVE
810 820 830 840 850
LTSEAVTALE QVEETEMVSA VSRVTASPDT SGETTPVPGD GVERKTDVVI
860 870 880 890 900
QEAVETISVT TNAMAVTMTE EQETVVAITT DALLVESATK EQKTVLVAHE
910 920 930 940 950
KNEAVAVCTG LDTSEIRAVE EESLNQKPSV ESATVVSQPL VTEVAVEEKT
960 970 980 990 1000
QEPERVTVTE DEVHEAQTSG VQAELKDQPI ENAIEEKAQF EEIKDTPIAE
1010 1020 1030 1040 1050
TVADIHEVAA VKVAVISAVQ QEPEILEEPV MAEKSPEIES AGPVEATVEE
1060 1070 1080 1090 1100
AICAQTAEVT EVAVAEGEKV QELDDVKETV ATVEVASVEN VSTAVTEEVM
1110 1120 1130 1140 1150
ATLPEVPASQ IAGSTEDPIP VVAATEEFAV IKETICVSSI SETTESHSAD
1160 1170 1180 1190 1200
IAKETLMENV PVVLSTGDHK MQVAVNEVEV VSAQGVVEGN IEAASTKLSV
1210 1220 1230 1240 1250
ALEEVTENVK EETEIIQATQ VTEAEIIEKQ SSVIVQEIIQ NVVENFAEAH
1260 1270 1280 1290 1300
GEQNVSEKTT EESCITSAEV KVNEISVETT EEGSSTDKLA ASDNVCKDVE
1310 1320 1330 1340 1350
ETRIVTEKPP KIVNEAIQIA ETVPVSITDE IQAQNEEVAS VSVADVHQET
1360 1370 1380 1390 1400
EVTKSEVELK QAEEKSQSTK NEEGISEVES DLKEVQAEIQ QEIKAVPEEK
1410 1420 1430 1440 1450
TAETSVTVAS QDQVVAEQCQ VTLTAVQIET AQEFNVGVVN VINADDVPET
1460 1470 1480 1490 1500
NMKEDCSEGQ ESTEDRPQND LEEPQTKVST NQEESRGPDC QKTDAKNVPA
1510 1520 1530
KLEAASEMTS NATAAEEVGN EIEPVSTEVV TVS
Length:1,533
Mass (Da):165,555
Last modified:May 31, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE05807A9B44B193
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Q9F2A0A2R8Q9F2_DANRE
A kinase (PRKA) anchor protein 12b
akap12b
1,596Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IC31A0A0R4IC31_DANRE
A kinase (PRKA) anchor protein 12b
akap12b
1,596Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QBS2A0A2R8QBS2_DANRE
A kinase (PRKA) anchor protein 12b
akap12b
1,506Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MPJ0A0A0A0MPJ0_DANRE
A kinase (PRKA) anchor protein 12b
akap12b
216Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU041395 Genomic DNA No translation available.
CU179733 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001091654.2, NM_001098184.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000110883; ENSDARP00000103304; ENSDARG00000055678
ENSDART00000182330; ENSDARP00000153177; ENSDARG00000055678

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
567365

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:567365

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU041395 Genomic DNA No translation available.
CU179733 Genomic DNA No translation available.
RefSeqiNP_001091654.2, NM_001098184.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000103304

Proteomic databases

PaxDbiF2Z4T4
PRIDEiF2Z4T4

Genome annotation databases

EnsembliENSDART00000110883; ENSDARP00000103304; ENSDARG00000055678
ENSDART00000182330; ENSDARP00000153177; ENSDARG00000055678
GeneIDi567365
KEGGidre:567365

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
567365
ZFINiZDB-GENE-030131-9753 akap12b

Phylogenomic databases

eggNOGiENOG410IFC9 Eukaryota
ENOG4110Y3C LUCA
GeneTreeiENSGT00730000111244
InParanoidiF2Z4T4
KOiK16528
OrthoDBi620777at2759

Gene expression databases

BgeeiENSDARG00000055678 Expressed in 44 organ(s), highest expression level in multi-cellular organism
ExpressionAtlasiF2Z4T4 baseline

Family and domain databases

InterProiView protein in InterPro
IPR028540 AKAP12
IPR001573 Pkinase-A_anch_WSK-motif
PANTHERiPTHR23209 PTHR23209, 2 hits
PfamiView protein in Pfam
PF03832 WSK, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF2Z4T4_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F2Z4T4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: October 16, 2019
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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