UniProtKB - F2Z4Q6 (F2Z4Q6_CANLF)
Protein
Submitted name:
Serum albumin
Gene
AFP
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 134 | ZincUniRule annotation | 1 | |
Metal bindingi | 166 | ZincUniRule annotation | 1 | |
Sitei | 252 | Aspirin-acetylated lysineUniRule annotation | 1 | |
Binding sitei | 293 | BilirubinUniRule annotation | 1 | |
Metal bindingi | 300 | ZincUniRule annotation | 1 | |
Metal bindingi | 302 | ZincUniRule annotation | 1 |
GO - Molecular functioni
- fatty acid binding Source: GO_Central
- zinc ion binding Source: GO_Central
Keywordsi
Ligand | Metal-bindingUniRule annotation, ZincUniRule annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Serum albuminImported |
Gene namesi | |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris)Imported |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:37692, AFP |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular space Source: InterPro
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 120 ↔ 129 | UniRule annotation | ||
Disulfide bondi | 142 ↔ 158 | UniRule annotation | ||
Disulfide bondi | 157 ↔ 168 | UniRule annotation | ||
Disulfide bondi | 177 ↔ 222 | UniRule annotation | ||
Disulfide bondi | 221 ↔ 230 | UniRule annotation | ||
Disulfide bondi | 253 ↔ 299 | UniRule annotation | ||
Disulfide bondi | 298 ↔ 306 | UniRule annotation | ||
Disulfide bondi | 318 ↔ 332 | UniRule annotation | ||
Disulfide bondi | 331 ↔ 342 | UniRule annotation | ||
Disulfide bondi | 369 ↔ 414 | UniRule annotation | ||
Disulfide bondi | 413 ↔ 422 | UniRule annotation | ||
Disulfide bondi | 445 ↔ 491 | UniRule annotation | ||
Disulfide bondi | 490 ↔ 501 | UniRule annotation | ||
Disulfide bondi | 514 ↔ 530 | UniRule annotation | ||
Disulfide bondi | 529 ↔ 540 | UniRule annotation | ||
Disulfide bondi | 567 ↔ 612 | UniRule annotation | ||
Disulfide bondi | 611 ↔ 620 | UniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotationARBA annotationProteomic databases
PRIDEi | F2Z4Q6 |
Expressioni
Gene expression databases
Bgeei | ENSCAFG00000003016, Expressed in liver and 45 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 62 – 239 | AlbuminInterPro annotationAdd BLAST | 178 | |
Domaini | 240 – 432 | AlbuminInterPro annotationAdd BLAST | 193 | |
Domaini | 433 – 630 | AlbuminInterPro annotationAdd BLAST | 198 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 37 | DisorderedSequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 22 | PolyampholyteSequence analysisAdd BLAST | 22 |
Keywords - Domaini
SignalARBA annotationPhylogenomic databases
GeneTreei | ENSGT00390000000113 |
HOGENOMi | CLU_030161_0_0_1 |
OrthoDBi | 906547at2759 |
TreeFami | TF335561 |
Family and domain databases
CDDi | cd00015, ALBUMIN, 3 hits |
InterProi | View protein in InterPro IPR000264, ALB/AFP/VDB IPR020858, Serum_albumin-like IPR021177, Serum_albumin/AFP/Afamin IPR020857, Serum_albumin_CS IPR014760, Serum_albumin_N |
PANTHERi | PTHR11385, PTHR11385, 1 hit |
Pfami | View protein in Pfam PF00273, Serum_albumin, 3 hits |
PIRSFi | PIRSF002520, Serum_albumin_subgroup, 1 hit |
PRINTSi | PR00802, SERUMALBUMIN |
SMARTi | View protein in SMART SM00103, ALBUMIN, 3 hits |
SUPFAMi | SSF48552, SSF48552, 3 hits |
PROSITEi | View protein in PROSITE PS00212, ALBUMIN_1, 2 hits PS51438, ALBUMIN_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
F2Z4Q6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTDTQRERQR HRQREKQAPC RDPDVGLDPG SPGSHPGQKV ALNRWATGAA
60 70 80 90 100
QQFHFYFSAY SRGLVRREAY KSEIAHRYND LGEEHFRGLV LVAFSQYLQQ
110 120 130 140 150
CPFEDHVKLA KEVTEFAKAC AAEESGANCD KSLHTLFGDK LCTVASLRDK
160 170 180 190 200
YGDMADCCEK QEPDRNECFL AHKDALCAAF QDNEQLFLGK YLYEIARRHP
210 220 230 240 250
YFYAPELLYY AQQYKGVFAE CCQAADKAAC LGPKIEALRE KVLLSSAKER
260 270 280 290 300
FKCASLQKFG DRAFKAWSVA RLSQRFPKAD FAEISKVVTD LTKVHKECCH
310 320 330 340 350
GDLLECADDR ADLAKYMCEN QDSISTKLKE CCDKPVLEKS QCLAEVERDE
360 370 380 390 400
LPGDLPSLAA DFVEDKEVCK NYQEAKDVFL GTFLYEYSRR HPEYSVSLLL
410 420 430 440 450
RLAKEYEATL EKCCATDDPP TCYAKVLDEF KPLVDEPQNL VKTNCELFEK
460 470 480 490 500
LGEYGFQNAL LVRYTKKAPQ VSTPTLVEVS RKLGKVGTKC CKKPESERMS
510 520 530 540 550
CADDFLSVVL NRLCVLHEKT PVSERVTKCC SESLVNRRPC FSGLEVDETY
560 570 580 590 600
VPKEFNAETF TFHADLCTLP EAEKQVKKQT ALVELLKHKP KATDEQLKTV
610 620 630
MGDFGAFVEK CCAAENKEGC FSEEGPKLVA AAQAALV
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE2R4E7 | E2R4E7_CANLF | Serum albumin | AFP ALB | 590 | Annotation score: | ||
F1PXN2 | F1PXN2_CANLF | Serum albumin | AFP ALB | 609 | Annotation score: | ||
A0A5F4DFR9 | A0A5F4DFR9_CANLF | Serum albumin | AFP ALB | 640 | Annotation score: | ||
A0A5F4CRM1 | A0A5F4CRM1_CANLF | Serum albumin | AFP ALB | 597 | Annotation score: | ||
A0A5F4DMQ6 | A0A5F4DMQ6_CANLF | Serum albumin | AFP ALB | 725 | Annotation score: | ||
A0A5F4CHV4 | A0A5F4CHV4_CANLF | Serum albumin | AFP ALB | 617 | Annotation score: | ||
E2QZ19 | E2QZ19_CANLF | Serum albumin | AFP ALB | 604 | Annotation score: | ||
A0A5F4CSX5 | A0A5F4CSX5_CANLF | Serum albumin | AFP ALB | 614 | Annotation score: | ||
A0A5F4C2N1 | A0A5F4C2N1_CANLF | Serum albumin | AFP ALB | 568 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAEX03009151 Genomic DNA No translation available. AAEX03009152 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSCAFT00000004843; ENSCAFP00000004489; ENSCAFG00000003020 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAEX03009151 Genomic DNA No translation available. AAEX03009152 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
Allergomei | 176, Can f 3 |
Proteomic databases
PRIDEi | F2Z4Q6 |
Genome annotation databases
Ensembli | ENSCAFT00000004843; ENSCAFP00000004489; ENSCAFG00000003020 |
Organism-specific databases
VGNCi | VGNC:37692, AFP |
Phylogenomic databases
GeneTreei | ENSGT00390000000113 |
HOGENOMi | CLU_030161_0_0_1 |
OrthoDBi | 906547at2759 |
TreeFami | TF335561 |
Gene expression databases
Bgeei | ENSCAFG00000003016, Expressed in liver and 45 other tissues |
Family and domain databases
CDDi | cd00015, ALBUMIN, 3 hits |
InterProi | View protein in InterPro IPR000264, ALB/AFP/VDB IPR020858, Serum_albumin-like IPR021177, Serum_albumin/AFP/Afamin IPR020857, Serum_albumin_CS IPR014760, Serum_albumin_N |
PANTHERi | PTHR11385, PTHR11385, 1 hit |
Pfami | View protein in Pfam PF00273, Serum_albumin, 3 hits |
PIRSFi | PIRSF002520, Serum_albumin_subgroup, 1 hit |
PRINTSi | PR00802, SERUMALBUMIN |
SMARTi | View protein in SMART SM00103, ALBUMIN, 3 hits |
SUPFAMi | SSF48552, SSF48552, 3 hits |
PROSITEi | View protein in PROSITE PS00212, ALBUMIN_1, 2 hits PS51438, ALBUMIN_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F2Z4Q6_CANLF | |
Accessioni | F2Z4Q6Primary (citable) accession number: F2Z4Q6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 31, 2011 |
Last sequence update: | December 11, 2019 | |
Last modified: | February 10, 2021 | |
This is version 74 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |