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Protein
Submitted name:

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

Gene

Raph1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • axon extension Source: MGI
  • signal transduction Source: InterPro

Names & Taxonomyi

Protein namesi
Submitted name:
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1Imported
Gene namesi
Name:Raph1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1924550 Raph1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiF2Z3U3
PeptideAtlasiF2Z3U3
PRIDEiF2Z3U3

PTM databases

iPTMnetiF2Z3U3

Expressioni

Gene expression databases

BgeeiENSMUSG00000026014 Expressed in 240 organ(s), highest expression level in utricle of membranous labyrinth
ExpressionAtlasiF2Z3U3 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiF2Z3U3, 1 interactor
MINTiF2Z3U3

Structurei

3D structure databases

ProteinModelPortaliF2Z3U3
SMRiF2Z3U3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini270 – 356Ras-associatingInterPro annotationAdd BLAST87
Domaini397 – 506PHInterPro annotationAdd BLAST110

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili153 – 173Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00550000074537
OMAiMSRAEPT
OrthoDBiEOG091G05PM

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00314 RA, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50200 RA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

F2Z3U3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQLSDEEID HGAEEDSDKE DQDLDKMFGA WLGELDRLTQ SLDSDKPKEP
60 70 80 90 100
VKRSPLRQET NMANFSYRFS IYNLNEALNQ GETVDLDALM ADLCSIEQEL
110 120 130 140 150
SSIGSGNSKR QVTEPKVPQK LPAGRHTSKH GTLRGPSSSS NRTTKPSHAN
160 170 180 190 200
YSLDDITAQL EQASLSMDEA AQQSLVEDPK PLVTNQHRRT ASAGTVSDAE
210 220 230 240 250
ARSISNSSRS SITSAASSMD SLDIDKVTRP QELDLTTHQG QPITEEEQAA
260 270 280 290 300
KLKAEKIRVA LEKIKEAQVK KLVIRVHMSD DSSKTMMVDE RQTVRQVLDN
310 320 330 340 350
LMDKSHCGYS LDWSLVETIS ELQMERIFED HENLVENLLN WTRDSQNKLI
360 370 380 390 400
FMERIEKYAL FKNPQNYLLG KKETAEMADR NKEVLLEECF CGSSVTVPEI
410 420 430 440 450
EGVLWLKDDG KKSWKKRYFL LRASGIYYVP KGKAKVSRDL VCFLQLDHVN
460 470 480 490 500
VYYGQDYRNK YKAPTDCCLA LKHPQIQKKS QYIKYLCCDD ARTLHQWVNG
510 520 530 540 550
IRIAKYGKQL YTNYQEALKR TESAYDWTSL SSSSIKSGSS SSSIPESQSN
560 570 580 590 600
HSNQSDSGVS DTLPTGHIRS QSTVSSIFSE AWKRGTQLEE SSKARMESMN
610 620 630 640 650
RSYTSLMPPL SPQTKIITPY TASQPSPPLP PPPPPPPPPP PPPPPPPPPL
660 670 680 690 700
PSQSAPSSGS AATMFVKYST ITRLQNAAQH SGTLFKSPTP PAMQPLPLAS
710 720 730 740 750
QSKAQIVVPP NGVIPPPPPP PPPPTPGSAM AQLKPVPCAP SLPQFSPQPP
760 770 780 790 800
PLKIHQVQHL PQTAPPTPPP APPITATVPP QAPPKPLVTI PPSASTKTVS
810 820 830 840 850
PVVAQAVPPT PAPPVPPAKK QPVFPVSHIP PTPPVQPTPH PPPTLPKQQS
860 870 880 890 900
FGVKPPPSPL SPVPSVVKQI ASQFPPPPTP PPVDSQPLKS LPASGTPQSP
910 920 930 940 950
PAVKAKPKWQ PSSIPVPSPD FPPPPPESSL VFPPPPPPAP APAPPPPPPP
960 970 980 990 1000
PPPPPPVPPT ASPTPDKGGS PGKKTSKMSS PGGKKPPPTP QRNSSIKSGS
1010 1020 1030 1040 1050
CAEHPEPKRP SVDSLVSKFA PPAESGSPSK ETPPPPAAPP KPGKLHLSGV
1060 1070 1080 1090 1100
NLPGIHQQGI VSAKASVLSG RGKDVVVEFP SPPSDSDFPP PPPEIELPLP
1110 1120 1130 1140 1150
PIEIPAVFSG NTSPKVAVVN PQPQLWSKTS VKKAPPPTRP KRNDSTRLTQ
1160 1170 1180 1190 1200
ADISEQPAMT TVVPQVPTSP KSSLSVQPGF LADLNRTLQR KSITRHGSLS
1210 1220 1230 1240 1250
SSRMSRAEPT ATMDDMALPP PPPELLSDQQ KAGFGGSHIS GYATLRRGPP
1260
PAPPKRDQNT KLSRDW
Length:1,266
Mass (Da):136,739
Last modified:October 29, 2014 - v2
Checksum:iE11247B774A40316
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z4B7F2Z4B7_MOUSE
Ras association (RalGDS/AF-6) and p...
Raph1
645Annotation score:
G5E867G5E867_MOUSE
MCG116540, isoform CRA_b
Raph1 mCG_116540
679Annotation score:
F2Z3X7F2Z3X7_MOUSE
Ras association (RalGDS/AF-6) and p...
Raph1
213Annotation score:
S4R2K5S4R2K5_MOUSE
Ras association (RalGDS/AF-6) and p...
Raph1
216Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC158969 Genomic DNA No translation available.
AL683804 Genomic DNA No translation available.
RefSeqiNP_001038978.3, NM_001045513.3
UniGeneiMm.440325

Genome annotation databases

EnsembliENSMUST00000140485; ENSMUSP00000121023; ENSMUSG00000026014
GeneIDi77300
KEGGimmu:77300
UCSCiuc007bet.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC158969 Genomic DNA No translation available.
AL683804 Genomic DNA No translation available.
RefSeqiNP_001038978.3, NM_001045513.3
UniGeneiMm.440325

3D structure databases

ProteinModelPortaliF2Z3U3
SMRiF2Z3U3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiF2Z3U3, 1 interactor
MINTiF2Z3U3

PTM databases

iPTMnetiF2Z3U3

Proteomic databases

MaxQBiF2Z3U3
PeptideAtlasiF2Z3U3
PRIDEiF2Z3U3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000140485; ENSMUSP00000121023; ENSMUSG00000026014
GeneIDi77300
KEGGimmu:77300
UCSCiuc007bet.2 mouse

Organism-specific databases

CTDi65059
MGIiMGI:1924550 Raph1

Phylogenomic databases

GeneTreeiENSGT00550000074537
OMAiMSRAEPT
OrthoDBiEOG091G05PM

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026014 Expressed in 240 organ(s), highest expression level in utricle of membranous labyrinth
ExpressionAtlasiF2Z3U3 baseline and differential

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00314 RA, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50200 RA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF2Z3U3_MOUSE
AccessioniPrimary (citable) accession number: F2Z3U3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: October 29, 2014
Last modified: September 12, 2018
This is version 54 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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