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Entry version 77 (18 Sep 2019)
Sequence version 3 (26 Jun 2013)
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Protein
Submitted name:

Transformation/transcription domain-associated protein

Gene

TRRAP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinasePROSITE-ProRule annotation, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Transformation/transcription domain-associated proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRRAPImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12347 TRRAP

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000196367

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
F2Z2U4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
23807

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196367 Expressed in 188 organ(s), highest expression level in corpus callosum

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2686 – 3246FATInterPro annotationAdd BLAST561
Domaini3517 – 3728PI3K/PI4KInterPro annotationAdd BLAST212
Domaini3816 – 3848FATCInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni491 – 541DisorderedSequence analysisAdd BLAST51
Regioni2004 – 2025DisorderedSequence analysisAdd BLAST22
Regioni2525 – 2560DisorderedSequence analysisAdd BLAST36
Regioni3256 – 3278DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2768 – 2792Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi491 – 525Pro-richSequence analysisAdd BLAST35
Compositional biasi2009 – 2025PolarSequence analysisAdd BLAST17
Compositional biasi3258 – 3277PolarSequence analysisAdd BLAST20

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0889 Eukaryota
COG5032 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017961

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
IPR033317 TRA1/TRRAP

The PANTHER Classification System

More...
PANTHERi
PTHR11139:SF1 PTHR11139:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02259 FAT, 1 hit
PF00454 PI3_PI4_kinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 3 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

F2Z2U4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFVATQGAT VVDQTTLMKK YLQFVAALTD VNTPDETKLK MMQEVSENFE
60 70 80 90 100
NVTSSPQYST FLEHIIPRFL TFLQDGEVQF LQEKPAQQLR KLVLEIIHRI
110 120 130 140 150
PTNEHLRPHT KNVLSVMFRF LETENEENVL ICLRIIIELH KQFRPPITQE
160 170 180 190 200
IHHFLDFVKQ IYKELPKVVN RYFENPQVIP ENTVPPPEMV GMITTIAVKV
210 220 230 240 250
NPEREDSETR THSIIPRGSL SLKVLAELPI IVVLMYQLYK LNIHNVVAEF
260 270 280 290 300
VPLIMNTIAI QVSAQARQHK LYNKELYADF IAAQIKTLSF LAYIIRIYQE
310 320 330 340 350
LVTKYSQQMV KGMLQLLSNC PAETAHLRKE LLIAAKHILT TELRNQFIPC
360 370 380 390 400
MDKLFDESIL IGSGYTARET LRPLAYSTLA DLVHHVRQHL PLSDLSLAVQ
410 420 430 440 450
LFAKNIDDES LPSSIQTMSC KLLLNLVDCI RSKSEQESGN GRDVLMRMLE
460 470 480 490 500
VFVLKFHTIA RYQLSAIFKK CKPQSELGAV EAALPGVPTA PAAPGPAPSP
510 520 530 540 550
APVPAPPPPP PPPPPATPVT PAPVPPFEKQ GEKDKEDKQT FQVTDCRSLV
560 570 580 590 600
KTLVCGVKTI TWGITSCKAP GAQFIPNKQL QPKETQIYIK LVKYAMQALD
610 620 630 640 650
IYQVQIAGNG QTYIRVANCQ TVRMKEEKEV LEHFAGVFTM MNPLTFKEIF
660 670 680 690 700
QTTVPYMVER ISKNYALQIV ANSFLANPTT SALFATILVE YLLDRLPEMG
710 720 730 740 750
SNVELSNLYL KLFKLVFGSV SLFAAENEQM LKPHLHKIVN SSMELAQTAK
760 770 780 790 800
EPYNYFLLLR ALFRSIGGGS HDLLYQEFLP LLPNLLQGLN MLQSGLHKQH
810 820 830 840 850
MKDLFVELCL TVPVRLSSLL PYLPMLMDPL VSALNGSQTL VSQGLRTLEL
860 870 880 890 900
CVDNLQPDFL YDHIQPVRAE LMQALWRTLR NPADSISHVA YRVLGKFGGS
910 920 930 940 950
NRKMLKESQK LHYVVTEVQG PSITVEFSDC KASLQLPMEK AIETALDCLK
960 970 980 990 1000
SANTEPYYRR QAWEVIKCFL VAMMSLEDNK HALYQLLAHP NFTEKTIPNV
1010 1020 1030 1040 1050
IISHRYKAQD TPARKTFEQA LTGAFMSAVI KDLRPSALPF VASLIRHYTM
1060 1070 1080 1090 1100
VAVAQQCGPF LLPCYQVGSQ PSTAMFHSEE NGSKGMDPLV LIDAIAICMA
1110 1120 1130 1140 1150
YEEKELCKIG EVALAVIFDV ASIILGSKER ACQLPLFSYI VERLCACCYE
1160 1170 1180 1190 1200
QAWYAKLGGV VSIKFLMERL PLTWVLQNQQ TFLKALLFVM MDLTGEVSNG
1210 1220 1230 1240 1250
AVAMAKTTLE QLLMRCATPL KDEERAEEIV AAQEKSFHHV THDLVREVTS
1260 1270 1280 1290 1300
PNSTVRKQAM HSLQVLAQVT GKSVTVIMEP HKEVLQDMVP PKKHLLRHQP
1310 1320 1330 1340 1350
ANAQIGLMEG NTFCTTLQPR LFTMDLNVVE HKVFYTELLN LCEAEDSALT
1360 1370 1380 1390 1400
KLPCYKSLPS LVPLRIAALN ALAACNYLPQ SREKIIAALF KALNSTNSEL
1410 1420 1430 1440 1450
QEAGEACMRK FLEGATIEVD QIHTHMRPLL MMLGDYRSLT LNVVNRLTSV
1460 1470 1480 1490 1500
TRLFPNSFND KFCDQMMQHL RKWMEVVVIT HKGGQRSDGN EMKICSAIIN
1510 1520 1530 1540 1550
LFHLIPAAPQ TLVKPLLEVV MKTERAMLIE AGSPFREPLI KFLTRHPSQT
1560 1570 1580 1590 1600
VELFMMEATL NDPQWSRMFM SFLKHKDARP LRDVLAANPN RFITLLLPGG
1610 1620 1630 1640 1650
AQTAVRPGSP STSTMRLDLQ FQAIKIISII VKNDDSWLAS QHSLVSQLRR
1660 1670 1680 1690 1700
VWVSENFQER HRKENMAATN WKEPKLLAYC LLNYCKRNYG DIELLFQLLR
1710 1720 1730 1740 1750
AFTGRFLCNM TFLKEYMEEE IPKNYSIAQK RALFFRFVDF NDPNFGDELK
1760 1770 1780 1790 1800
AKVLQHILNP AFLYSFEKGE GEQLLGPPNP EGDNPESITS VFITKVLDPE
1810 1820 1830 1840 1850
KQADMLDSLR IYLLQYATLL VEHAPHHIHD NNKNRNSKLR RLMTFAWPCL
1860 1870 1880 1890 1900
LSKACVDPAC KYSGHLLLAH IIAKFAIHKK IVLQVFHSLL KAHAMEARAI
1910 1920 1930 1940 1950
VRQAMAILTP AVPARMEDGH QMLTHWTRKI IVEEGHTVPQ LVHILHLIVQ
1960 1970 1980 1990 2000
HFKVYYPVRH HLVQHMVSAM QRLGFTPSVT IEQRRLAVDL SEVVIKWELQ
2010 2020 2030 2040 2050
RIKDQQPDSD MDPNSSGEGV NSVSSSIKRG LSVDSAQEVK RFRTATGAIS
2060 2070 2080 2090 2100
AVFGRSQSLP GADSLLAKPI DKQHTDTVVN FLIRVACQVN DNTNTAGSPG
2110 2120 2130 2140 2150
EVLSRRCVNL LKTALRPDMW PKSELKLQWF DKLLMTVEQP NQVNYGNICT
2160 2170 2180 2190 2200
GLEVLSFLLT VLQSPAILSS FKPLQRGIAA CMTCGNTKVL RAVHSLLSRL
2210 2220 2230 2240 2250
MSIFPTEPST SSVASKYEEL ECLYAAVGKV IYEGLTNYEK ATNANPSQLF
2260 2270 2280 2290 2300
GTLMILKSAC SNNPSYIDRL ISVFMRSLQK MVREHLNPQA ASGSTEATSA
2310 2320 2330 2340 2350
GTSELVMLSL ELVKTRLAVM SMEMRKNFIQ AILTSLIEKS PDAKILRAVV
2360 2370 2380 2390 2400
KIVEEWVKNN SPMAANQTPT LREKSILLVK MMTYIEKRFP EDLELNAQFL
2410 2420 2430 2440 2450
DLVNYVYRDE TLSGSELTAK LEPAFLSGLR CAQPLIRAKF FEVFDNSMKR
2460 2470 2480 2490 2500
RVYERLLYVT CSQNWEAMGN HFWIKQCIEL LLAVCEKSTP IGTSCQGAML
2510 2520 2530 2540 2550
PSITNVINLA DSHDRAAFAM VTHVKQEPRE RENSESKEED VEIDIELAPG
2560 2570 2580 2590 2600
DQTSTPKTKE LSEKDIGNQL HMLTNRHDKF LDTLREVKTG ALLSAFVQLC
2610 2620 2630 2640 2650
HISTTLAEKT WVQLFPRLWK ILSDRQQHAL AGEISPFLCS GSHQVQRDCQ
2660 2670 2680 2690 2700
PSALNCFVEA MSQCVPPIPI RPCVLKYLGK THNLWFRSTL MLEHQAFEKG
2710 2720 2730 2740 2750
LSLQIKPKQT TEFYEQESIT PPQQEILDSL AELYSLLQEE DMWAGLWQKR
2760 2770 2780 2790 2800
CKYSETATAI AYEQHGFFEQ AQESYEKAMD KAKKEHERSN ASPAIFPEYQ
2810 2820 2830 2840 2850
LWEDHWIRCS KELNQWEALT EYGQSKGHIN PYLVLECAWR VSNWTAMKEA
2860 2870 2880 2890 2900
LVQVEVSCPK EMAWKVNMYR GYLAICHPEE QQLSFIERLV EMASSLAIRE
2910 2920 2930 2940 2950
WRRLPHVVSH VHTPLLQAAQ QIIELQEAAQ INAGLQPTNL GRNNSLHDMK
2960 2970 2980 2990 3000
TVVKTWRNRL PIVSDDLSHW SSIFMWRQHH YQAIVTAYEN SSQHDPSSNN
3010 3020 3030 3040 3050
AMLGVHASAS AIIQYGKIAR KQGLVNVALD ILSRIHTIPT VPIVDCFQKI
3060 3070 3080 3090 3100
RQQVKCYLQL AGVMGKNECM QGLEVIESTN LKYFTKEMTA EFYALKGMFL
3110 3120 3130 3140 3150
AQINKSEEAN KAFSAAVQMH DVLVKAWAMW GDYLENIFVK ERQLHLGVSA
3160 3170 3180 3190 3200
ITCYLHACRH QNESKSRKYL AKVLWLLSFD DDKNTLADAV DKYCIGVPPI
3210 3220 3230 3240 3250
QWLAWIPQLL TCLVGSEGKL LLNLISQVGR VYPQAVYFPI RTLYLTLKIE
3260 3270 3280 3290 3300
QRERYKSDSG QQQPSSVGNQ SHSASDPGPI RATAPMWRCS RIMHMQRELH
3310 3320 3330 3340 3350
PTLLSSLEGI VDQMVWFREN WHEEVLRQLQ QGLAKCYSVA FEKSGAVSDA
3360 3370 3380 3390 3400
KITPHTLNFV KKLVSTFGVG LENVSNVSTM FSSAASESLA RRAQATAQDP
3410 3420 3430 3440 3450
VFQKLKGQFT TDFDFSVPGS MKLHNLISKL KKWIKILEAK TKQLPKFFLI
3460 3470 3480 3490 3500
EEKCRFLSNF SAQTAEVEIP GEFLMPKPTH YYIKIARFMP RVEIVQKHNT
3510 3520 3530 3540 3550
AARRLYIRGH NGKIYPYLVM NDACLTESRR EERVLQLLRL LNPCLEKRKE
3560 3570 3580 3590 3600
TTKRHLFFTV PRVVAVSPQM RLVEDNPSSL SLVEIYKQRC AKKGIEHDNP
3610 3620 3630 3640 3650
ISRYYDRLAT VQARGTQASH QVLRDILKEV QSNMVPRSML KEWALHTFPN
3660 3670 3680 3690 3700
ATDYWTFRKM FTIQLALIGF AEFVLHLNRL NPEMLQIAQD TGKLNVAYFR
3710 3720 3730 3740 3750
FDINDATGDL DANRPVPFRL TPNISEFLTT IGVSGPLTAS MIAVARCFAQ
3760 3770 3780 3790 3800
PNFKVDGILK TVLRDEIIAW HKKTQEDTSS PLSAAGQPEN MDSQQLVSLV
3810 3820 3830 3840
QKAVTAIMTR LHNLAQFEGG ESKVNTLVAA ANSLDNLCRM DPAWHPWL
Length:3,848
Mass (Da):436,138
Last modified:June 26, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3DD613D56AE6B020
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9Y4A5TRRAP_HUMAN
Transformation/transcription domain...
TRRAP PAF400
3,859Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4W2H0Y4W2_HUMAN
Transformation/transcription domain...
TRRAP
3,588Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YFJ4A0A2R8YFJ4_HUMAN
Transformation/transcription domain...
TRRAP
1,344Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K0N1C9K0N1_HUMAN
Transformation/transcription domain...
TRRAP
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC004893 Genomic DNA No translation available.
AC004991 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000446306; ENSP00000403708; ENSG00000196367
ENST00000628380; ENSP00000485781; ENSG00000196367

UCSC genome browser

More...
UCSCi
uc064frt.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004893 Genomic DNA No translation available.
AC004991 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiF2Z2U4
ProteomicsDBi23807

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000446306; ENSP00000403708; ENSG00000196367
ENST00000628380; ENSP00000485781; ENSG00000196367
UCSCiuc064frt.1 human

Organism-specific databases

HGNCiHGNC:12347 TRRAP
OpenTargetsiENSG00000196367

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0889 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00390000017961

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TRRAP human

Gene expression databases

BgeeiENSG00000196367 Expressed in 188 organ(s), highest expression level in corpus callosum

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
IPR033317 TRA1/TRRAP
PANTHERiPTHR11139:SF1 PTHR11139:SF1, 1 hit
PfamiView protein in Pfam
PF02259 FAT, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
SMARTiView protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF2Z2U4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F2Z2U4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: June 26, 2013
Last modified: September 18, 2019
This is version 77 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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