UniProtKB - F2WHQ0 (F2WHQ0_HUMAN)
Protein
Cytochrome c oxidase subunit 1
Gene
COX1
Organism
Homo sapiens (Human)
Status
Functioni
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.UniRule annotation
Catalytic activityi
- EC:7.1.1.9UniRule annotation
Cofactori
Protein has several cofactor binding sites:: oxidative phosphorylation Pathwayi
This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotationARBA annotationView all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.
GO - Molecular functioni
- cytochrome-c oxidase activity Source: InterPro
- heme binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- aerobic respiration Source: InterPro
- oxidative phosphorylation Source: UniProtKB-UniPathway
Keywordsi
Molecular function | TranslocaseARBA annotation |
Biological process | Electron transport, Respiratory chainUniRule annotationARBA annotation, Transport |
Ligand | CalciumARBA annotation, CopperUniRule annotationARBA annotation, HemeUniRule annotation, Iron, MagnesiumARBA annotation, Metal-binding, SodiumARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00705 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:COX1Imported |
Encoded oni | MitochondrionImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- respiratory chain complex IV Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 18 – 37 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 57 – 83 | HelicalSequence analysisAdd BLAST | 27 | |
Transmembranei | 104 – 128 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 148 – 171 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 183 – 210 | HelicalSequence analysisAdd BLAST | 28 | |
Transmembranei | 243 – 261 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 268 – 291 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 303 – 325 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 337 – 359 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 379 – 400 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 412 – 430 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 450 – 473 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotationARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 511 | COX1InterPro annotationAdd BLAST | 511 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationFamily and domain databases
CDDi | cd01663, Cyt_c_Oxidase_I, 1 hit |
Gene3Di | 1.20.210.10, 1 hit |
InterProi | View protein in InterPro IPR023616, Cyt_c_oxase-like_su1_dom IPR036927, Cyt_c_oxase-like_su1_sf IPR000883, Cyt_C_Oxase_1 IPR023615, Cyt_c_Oxase_su1_BS IPR033944, Cyt_c_oxase_su1_dom |
PANTHERi | PTHR10422, PTHR10422, 1 hit |
Pfami | View protein in Pfam PF00115, COX1, 1 hit |
PRINTSi | PR01165, CYCOXIDASEI |
SUPFAMi | SSF81442, SSF81442, 1 hit |
PROSITEi | View protein in PROSITE PS50855, COX1, 1 hit PS00077, COX1_CUB, 1 hit |
i Sequence
Sequence statusi: Complete.
F2WHQ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFADRWLFST NHKDIGTLYL LFGAWAGVLG TALSLLIRAE LGQPGNLXGN
60 70 80 90 100
DHIYNVIVTA HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM
110 120 130 140 150
SFWLLPPSLL LLLASAMVEA GAGTGWTVYP PLAGNYSHPG ASVDLTIFSL
160 170 180 190 200
HLAGVSSILG AINFITTIIN MKPPAMTQYQ TPLFVWSVLI TAVLLLLSLP
210 220 230 240 250
VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG
260 270 280 290 300
FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD
310 320 330 340 350
TRAYFTSATM IIAIPTGVKV FSWLATLHGS NMKWSAAVLW ALGFIFLFTV
360 370 380 390 400
GGLTGIVLAN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFIHWFPLF
410 420 430 440 450
SGYTLDQTYA KIHFTIMFIG VNLTFFPQHF LGLSGMPRRY SDYPDAYTTW
460 470 480 490 500
NILSSVGSFI SLTAVMLMIF MIWEAFASKR KVLMVEEPSM NLEWLYGCPP
510
PYHTFEEPVY MKS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM852857 Genomic DNA Translation: ADL31209.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM852857 Genomic DNA Translation: ADL31209.1 |
3D structure databases
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | F2WHQ0 |
Enzyme and pathway databases
UniPathwayi | UPA00705 |
Family and domain databases
CDDi | cd01663, Cyt_c_Oxidase_I, 1 hit |
Gene3Di | 1.20.210.10, 1 hit |
InterProi | View protein in InterPro IPR023616, Cyt_c_oxase-like_su1_dom IPR036927, Cyt_c_oxase-like_su1_sf IPR000883, Cyt_C_Oxase_1 IPR023615, Cyt_c_Oxase_su1_BS IPR033944, Cyt_c_oxase_su1_dom |
PANTHERi | PTHR10422, PTHR10422, 1 hit |
Pfami | View protein in Pfam PF00115, COX1, 1 hit |
PRINTSi | PR01165, CYCOXIDASEI |
SUPFAMi | SSF81442, SSF81442, 1 hit |
PROSITEi | View protein in PROSITE PS50855, COX1, 1 hit PS00077, COX1_CUB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F2WHQ0_HUMAN | |
Accessioni | F2WHQ0Primary (citable) accession number: F2WHQ0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 31, 2011 |
Last sequence update: | May 31, 2011 | |
Last modified: | December 2, 2020 | |
This is version 50 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |