Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

TRM8

Organism
Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot fungus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotationSAAS annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei204S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Active sitei207UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseUniRule annotationSAAS annotationImported, RNA-binding, Transferase, tRNA-bindingUniRule annotationSAAS annotation
Biological processtRNA processingUniRule annotationSAAS annotation
LigandS-adenosyl-L-methionineUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
Transfer RNA methyltransferase 8UniRule annotation
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:TRM8UniRule annotation
ORF Names:TERG_02914Imported
OrganismiTrichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot fungus)Imported
Taxonomic identifieri559305 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeTrichophyton
Proteomesi
  • UP000008864 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Forms a complex with TRM82.UniRule annotation

Protein-protein interaction databases

STRINGi559305.XP_003235862.1

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni117 – 118S-adenosyl-L-methionine bindingUniRule annotation2
Regioni184 – 185S-adenosyl-L-methionine bindingUniRule annotation2
Regioni294 – 296S-adenosyl-L-methionine bindingUniRule annotation3

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3115 Eukaryota
COG0220 LUCA
InParanoidiF2SLK1
OrthoDBiEOG092C3FCG

Family and domain databases

HAMAPiMF_03055 tRNA_methyltr_TrmB_euk, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR025763 Trm8_euk
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
PTHR23417:SF16 PTHR23417:SF16, 1 hit
SUPFAMiSSF53335 SSF53335, 2 hits
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

F2SLK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASDQRKQQ RAEPRKPLEG KTDENGQITL PKKKLYRQRA HANPFSDHQL
60 70 80 90 100
DYPISPDHMD WSKLFPAYVD PDPAAVNISG ARKLVKNVEI ADIGCGFGGL
110 120 130 140 150
LVALAPLMPD TLMVGMEIRS SVLEYVTERI RALRSRYPPP AAPDAIADAA
160 170 180 190 200
SKPEDAPGAV SLPSTQLNVL GQPNFQNIFA IRSNTMKFLP NFFFRHQLSK
210 220 230 240 250
IFICFPDPHF KARKHKARIV STTLNAEYAY VLRPGGMLYT ITDVEDLHLW
260 270 280 290 300
MVSHFDAKSA DKDLNSHDIA ELWERVSDEE LATDECVQVM REETEEGKKV
310 320
TRNNGQKFVA VWRRKADPEW PS
Length:322
Mass (Da):36,353
Last modified:May 31, 2011 - v1
Checksum:i67A648E30918DD7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG700650 Genomic DNA Translation: EGD86657.1
RefSeqiXP_003235862.1, XM_003235814.1

Genome annotation databases

EnsemblFungiiEGD86657; EGD86657; TERG_02914
GeneIDi10378234

Similar proteinsi

Entry informationi

Entry nameiF2SLK1_TRIRC
AccessioniPrimary (citable) accession number: F2SLK1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: May 23, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health