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Entry version 53 (02 Jun 2021)
Sequence version 1 (31 May 2011)
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Protein

Aminodeoxychorismate synthase

Gene

cmlB

Organism
Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in chloramphenicol biosynthesis (PubMed:8704974).

Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine (By similarity).

By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Antibiotic biosynthesis

This protein is involved in Antibiotic biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei81NucleophilePROSITE-ProRule annotation1
Active sitei168PROSITE-ProRule annotation1
Active sitei170PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMultifunctional enzyme, Transferase
Biological processAntibiotic biosynthesis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-20700

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C26.A25

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aminodeoxychorismate synthaseCurated (EC:2.6.1.85By similarity)
Short name:
ADC synthaseCurated
Alternative name(s):
4-amino-4-deoxychorismate synthaseCurated
p-aminobenzoate synthase1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cmlB1 Publication
Synonyms:pabAB1 Publication
Ordered Locus Names:SVEN_0920Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri953739 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006854 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Disruption of the gene decreases sulfanilamide resistance and blocks chloramphenicol production.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004472181 – 686Aminodeoxychorismate synthaseAdd BLAST686

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F2RB79

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 194Glutamine amidotransferase type-1PROSITE-ProRule annotationAdd BLAST193

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni233 – 686PABB componentCuratedAdd BLAST454

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the anthranilate synthase component I family.Curated

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0147, Bacteria
COG0512, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006493_0_1_11

Identification of Orthologs from Complete Genome Data

More...
OMAi
IRTMFRW

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01743, GATase1_Anthranilate_Synthase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.880, 1 hit
3.60.120.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005802, ADC_synth_comp_1
IPR005801, ADC_synthase
IPR006805, Anth_synth_I_N
IPR015890, Chorismate_C
IPR029062, Class_I_gatase-like
IPR017926, GATASE
IPR006221, TrpG/PapA_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04715, Anth_synt_I_N, 1 hit
PF00425, Chorismate_bind, 1 hit
PF00117, GATase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52317, SSF52317, 1 hit
SSF56322, SSF56322, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00553, pabB, 1 hit
TIGR00566, trpG_papA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51273, GATASE_TYPE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F2RB79-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTLLIDNYD SFTHNLFQYI GEATGQPPVV VPNDADWSRL PLEDFDAIVV
60 70 80 90 100
SPGPGSPDRE RDFGISRRAI TDSGLPVLGV CLGHQGIAQL FGGTVGLAPE
110 120 130 140 150
PMHGRVSEVR HTGEDVFRGL PSPFTAVRYH SLAATDLPDE LEPLAWSDDG
160 170 180 190 200
VVMGLRHREK PLWGVQFHPE SIGSDFGREI MANFRDLALA HHRARRDAAD
210 220 230 240 250
SPYELHVRRV DVLPDAEEVR RGCLPGEGAT FWLDSSSVLE GASRFSFLGD
260 270 280 290 300
DRGPLAEYLT YRVADGVVSV RGSDGTTTRT RRPFFSYLEE QLERRRVPVA
310 320 330 340 350
PDLPFEFNLG YVGYLGYELK AETTGDPAHR SPHPDAAFLF ADRAIALDHQ
360 370 380 390 400
EGCCYLLALD RRGHDDGARA WLRETAETLT GLAVRVPAEP TPAMVFGVPE
410 420 430 440 450
AAAGFGPLAR ARHDKDAYLK RIDECLKEIR NGESYEICLT NMVTAPTEAT
460 470 480 490 500
ALPLYSALRA ISPVPYGALL EFPELSVLSA SPERFLTIGA DGGVESKPIK
510 520 530 540 550
GTRPRGGTAE EDERLRADLA GREKDRAENL MIVDLVRNDL NSVCAIGSVH
560 570 580 590 600
VPRLFEVETY APVHQLVSTI RGRLRPGTST AACVRAAFPG GSMTGAPKKR
610 620 630 640 650
TMEIIDRLEE GPRGVYSGAL GWFALSGAAD LSIVIRTIVL ADGRAEFGVG
660 670 680
GAIVSLSDQE EEFTETVVKA RAMVTALDGS AVAGAR
Length:686
Mass (Da):74,547
Last modified:May 31, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i15EC60477BE75F5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14H → Q in AAB30312 (PubMed:8704974).Curated1
Sequence conflicti29Missing in AAB30312 (PubMed:8704974).Curated1
Sequence conflicti91 – 99FGGTVGLAP → SA in AAB30312 (PubMed:8704974).Curated9
Sequence conflicti163W → M in AAB30312 (PubMed:8704974).Curated1
Sequence conflicti168H → P in AAB30312 (PubMed:8704974).Curated1
Sequence conflicti201 – 202SP → WG in AAB30312 (PubMed:8704974).Curated2
Sequence conflicti222 – 226GCLPG → AACPA in AAB30312 (PubMed:8704974).Curated5
Sequence conflicti244R → P in AAB30312 (PubMed:8704974).Curated1
Sequence conflicti280 – 284TRRPF → DAATL in AAB30312 (PubMed:8704974).Curated5
Sequence conflicti294 – 297RRRV → PPAG in AAB30312 (PubMed:8704974).Curated4
Sequence conflicti329 – 331HRS → VPA in AAB30312 (PubMed:8704974).Curated3
Sequence conflicti387 – 389PAE → RPR in AAB30312 (PubMed:8704974).Curated3
Sequence conflicti418 – 429YLKRI…CLKEI → SAL in AAB30312 (PubMed:8704974).CuratedAdd BLAST12
Sequence conflicti460A → R in AAB30312 (PubMed:8704974).Curated1
Sequence conflicti466Y → S in AAB30312 (PubMed:8704974).Curated1
Sequence conflicti507 – 508GT → AP in AAB30312 (PubMed:8704974).Curated2
Sequence conflicti558 – 560ETY → GDL in AAB30312 (PubMed:8704974).Curated3
Sequence conflicti601T → P in AAB30312 (PubMed:8704974).Curated1
Sequence conflicti616 – 617YS → LP in AAB30312 (PubMed:8704974).Curated2
Sequence conflicti664 – 665TE → RQ in AAB30312 (PubMed:8704974).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U21728 Genomic DNA Translation: AAB30312.1
FR845719 Genomic DNA Translation: CCA54207.1

NCBI Reference Sequences

More...
RefSeqi
WP_015032126.1, NZ_CP029197.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CCA54207; CCA54207; SVEN_0920

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sve:SVEN_0920

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|953739.5.peg.2966

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21728 Genomic DNA Translation: AAB30312.1
FR845719 Genomic DNA Translation: CCA54207.1
RefSeqiWP_015032126.1, NZ_CP029197.1

3D structure databases

SMRiF2RB79
ModBaseiSearch...

Protein family/group databases

MEROPSiC26.A25

Genome annotation databases

EnsemblBacteriaiCCA54207; CCA54207; SVEN_0920
KEGGisve:SVEN_0920
PATRICifig|953739.5.peg.2966

Phylogenomic databases

eggNOGiCOG0147, Bacteria
COG0512, Bacteria
HOGENOMiCLU_006493_0_1_11
OMAiIRTMFRW

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-20700

Family and domain databases

CDDicd01743, GATase1_Anthranilate_Synthase, 1 hit
Gene3Di3.40.50.880, 1 hit
3.60.120.10, 1 hit
InterProiView protein in InterPro
IPR005802, ADC_synth_comp_1
IPR005801, ADC_synthase
IPR006805, Anth_synth_I_N
IPR015890, Chorismate_C
IPR029062, Class_I_gatase-like
IPR017926, GATASE
IPR006221, TrpG/PapA_dom
PfamiView protein in Pfam
PF04715, Anth_synt_I_N, 1 hit
PF00425, Chorismate_bind, 1 hit
PF00117, GATase, 1 hit
SUPFAMiSSF52317, SSF52317, 1 hit
SSF56322, SSF56322, 1 hit
TIGRFAMsiTIGR00553, pabB, 1 hit
TIGR00566, trpG_papA, 1 hit
PROSITEiView protein in PROSITE
PS51273, GATASE_TYPE_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADCS_STRVP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F2RB79
Secondary accession number(s): Q56151
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 8, 2019
Last sequence update: May 31, 2011
Last modified: June 2, 2021
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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