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Protein

Neuraminidase

Gene

NA

Organism
Influenza A virus (A/equine/Prague/2/1956(H7N7))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.UniRule annotationSAAS annotation

Cofactori

Ca2+UniRule annotationSAAS annotation

Activity regulationi

Inhibited by the neuraminidase inhibitors zanamivir (Relenza) and oseltamivir (Tamiflu). These drugs interfere with the release of progeny virus from infected cells and are effective against all influenza strains. Resistance to neuraminidase inhibitors is quite rare.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei115SubstrateUniRule annotation1
Active sitei148Proton donor/acceptorUniRule annotation1
Binding sitei149SubstrateUniRule annotation1
Binding sitei290SubstrateUniRule annotation1
Metal bindingi291Calcium; via carbonyl oxygenUniRule annotation1
Metal bindingi295Calcium; via carbonyl oxygenUniRule annotation1
Metal bindingi322CalciumUniRule annotation1
Binding sitei369SubstrateUniRule annotation1
Active sitei403NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotationSAAS annotation, Hydrolase
LigandCalciumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NeuraminidaseUniRule annotationSAAS annotation (EC:3.2.1.18UniRule annotationSAAS annotation)
Gene namesi
Name:NAUniRule annotationImported
OrganismiInfluenza A virus (A/equine/Prague/2/1956(H7N7))Imported
Taxonomic identifieri506420 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeAlphainfluenzavirus
Proteomesi
  • UP000173296 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 26HelicalUniRule annotationAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneUniRule annotationSAAS annotation, Host membrane, Membrane, VirionUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi121 ↔ 126UniRule annotation
Disulfide bondi181 ↔ 228UniRule annotation
Disulfide bondi230 ↔ 235UniRule annotation
Disulfide bondi276 ↔ 289UniRule annotation
Disulfide bondi278 ↔ 287UniRule annotation

Post-translational modificationi

N-glycosylated.UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation, GlycoproteinUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliF2P1D3
SMRiF2P1D3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – 33Involved in apical transport and lipid raft associationUniRule annotationAdd BLAST23
Regioni88 – 469Head of neuraminidaseUniRule annotationAdd BLAST382
Regioni274 – 275Substrate bindingUniRule annotation2

Domaini

Intact N-terminus is essential for virion morphogenesis. Possess two apical sorting signals, one in the ectodomain, which is likely to be a glycan, and the other in the transmembrane domain. The transmembrane domain also plays a role in lipid raft association.UniRule annotation

Sequence similaritiesi

Belongs to the glycosyl hydrolase 34 family.UniRule annotationSAAS annotation

Keywords - Domaini

Signal-anchorUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_04071 INFV_NRAM, 1 hit
InterProiView protein in InterPro
IPR001860 Glyco_hydro_34
IPR036278 Sialidase_sf
PfamiView protein in Pfam
PF00064 Neur, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit

Sequencei

Sequence statusi: Complete.

F2P1D3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPNQKLFAS SGIAIALGII NLLIGISNMS LNISLYSKGE NHKSDNLTCT
60 70 80 90 100
NINQNNTTMV NTYINNTTII DKNTKMENPG YLLLNKSLCN VEGWVVIAKD
110 120 130 140 150
NAIRFGESEQ IIVTREPYVS CDPLSCKMYA LHQGTTIRNK HSNGTTHDRT
160 170 180 190 200
AFRGLISTPL GNPPTVSNSE FICVGWSSTS CHDGVSRMTI CVQGNNENAT
210 220 230 240 250
ATVYYNKRLT TTIKTWAKNI LRTQESECVC HNSTCVVVMT DGPANNQAFT
260 270 280 290 300
KVIYFHKGTI IKEEPLKGSA KHIEECSCYG HNQRVTCVCR DNWQGANRPV
310 320 330 340 350
IEIDMNNLEH TSRYICTGVL TDTSRPKDKA IGECFNPITG SPGAPGIKGF
360 370 380 390 400
GFLNENNTWL GRTISPKLRS GFEMLKIPNA GTDPDSKIKE RQEIVGNDNW
410 420 430 440 450
SGYSGSFIDY WNDNSECYNP CFYVELIRGR PEEAKYVEWT SNSLIALCGS
460
PIPVGSGSFP DGAQIKYFS
Length:469
Mass (Da):51,890
Last modified:May 31, 2011 - v1
Checksum:i38A224BA86D9ADC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CY087818 Viral cRNA Translation: AEA04401.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CY087818 Viral cRNA Translation: AEA04401.1

3D structure databases

ProteinModelPortaliF2P1D3
SMRiF2P1D3
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_04071 INFV_NRAM, 1 hit
InterProiView protein in InterPro
IPR001860 Glyco_hydro_34
IPR036278 Sialidase_sf
PfamiView protein in Pfam
PF00064 Neur, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF2P1D3_9INFA
AccessioniPrimary (citable) accession number: F2P1D3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: October 10, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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