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Protein

Indolepyruvate oxidoreductase subunit IorA

Gene

TUZN_0362

Organism
Thermoproteus uzoniensis (strain 768-20)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.UniRule annotation

Catalytic activityi

(Indol-3-yl)pyruvate + CoA + 2 oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + 2 reduced ferredoxin + H+.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi532Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi535Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi538Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi544Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi562Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi565Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi568Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi572Iron-sulfur 1 (4Fe-4S)UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transportUniRule annotation, Transport
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding, PyruvateImported

Enzyme and pathway databases

BioCyciTUZO999630:G1GSD-358-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Indolepyruvate oxidoreductase subunit IorAUniRule annotation (EC:1.2.7.8UniRule annotation)
Short name:
IORUniRule annotation
Alternative name(s):
Indolepyruvate ferredoxin oxidoreductase subunit alphaUniRule annotation
Gene namesi
Ordered Locus Names:TUZN_0362Imported
OrganismiThermoproteus uzoniensis (strain 768-20)Imported
Taxonomic identifieri999630 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeThermoproteus
Proteomesi
  • UP000008138 Componenti: Chromosome

Interactioni

Subunit structurei

Heterodimer of the IorA and IorB subunits.UniRule annotation

Protein-protein interaction databases

STRINGi999630.TUZN_0362

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini523 – 5524Fe-4S ferredoxin-typeInterPro annotationAdd BLAST30
Domaini553 – 5824Fe-4S ferredoxin-typeInterPro annotationAdd BLAST30

Phylogenomic databases

eggNOGiarCOG01609 Archaea
COG4231 LUCA
KOiK00179
OMAiTFLHTGI

Family and domain databases

InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR017721 Indolepyruvate_Fd_OxRdtase_asu
IPR002880 Pyrv_Fd/Flavodoxin_OxRdtase_N
IPR029061 THDP-binding
IPR011766 TPP_enzyme-bd_C
IPR009014 Transketo_C/PFOR_II
PfamiView protein in Pfam
PF00037 Fer4, 1 hit
PF01855 POR_N, 1 hit
PF02775 TPP_enzyme_C, 1 hit
PIRSFiPIRSF006439 Indolepyruvate_ferr_oxidored, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
SSF52922 SSF52922, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits

Sequencei

Sequence statusi: Complete.

F2L2S1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRHLLLGNEA IAYGALSAGV AVAAGYPGTP SSEIIETLLE YRDRFVQWAS
60 70 80 90 100
NEKTAVEIAY GAALAGARAL AAMKHVGLNV AADPLHSAAY TGVVGGFLIV
110 120 130 140 150
TADDPNMWSS QNEQDTRWYG LQSYIPVLEP SDPQEAFKMA KEGLMLSEAL
160 170 180 190 200
EHPVILRSVT RVSHVRAPVV VEPPAPPKFG KFARNVERYV LVPQNARRRK
210 220 230 240 250
AEVLRRWDSF ADLSSRFLSI EGDGEVVVVA SGVGYLYAVE ALERLRVKAA
260 270 280 290 300
VVKVGMPVPL PKKLADVGAG EVVVVEEGDP VVEMQLRAMG VKTRGKIDGF
310 320 330 340 350
FPKIGELTLR SVVEGISKAL GLGVRLPDPP TPPLQPPPRP PYLCPGCPHM
360 370 380 390 400
GTFYAFKIAS AGQKVIWSGD IGCYTLGINT GQQDLATHMG SSLGLGMGIA
410 420 430 440 450
VADREKLVVA TVGDSTFYHA ALPQLIDLKT KKVPLVLVVM DNEYTAMTGG
460 470 480 490 500
QPSPSRSVPA ERLAEAVGVK HYVIDPADLK RSVEIAKAAV ADAKSGEPVV
510 520 530 540 550
VVSRRPCTLE ALRHARRSGF KPPKFYVVAD KCRSCGICYN VLKCYAIAKL
560 570 580 590
PDGKAWIDPS LCSGCSMCAQ VCPYDAIKPT EPEKVGKWLE LWSQA
Length:595
Mass (Da):64,017
Last modified:May 31, 2011 - v1
Checksum:iE2DF0AEF25454B4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002590 Genomic DNA Translation: AEA11859.1
RefSeqiWP_013679195.1, NC_015315.1

Genome annotation databases

EnsemblBacteriaiAEA11859; AEA11859; TUZN_0362
GeneIDi10359908
KEGGituz:TUZN_0362

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002590 Genomic DNA Translation: AEA11859.1
RefSeqiWP_013679195.1, NC_015315.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi999630.TUZN_0362

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEA11859; AEA11859; TUZN_0362
GeneIDi10359908
KEGGituz:TUZN_0362

Phylogenomic databases

eggNOGiarCOG01609 Archaea
COG4231 LUCA
KOiK00179
OMAiTFLHTGI

Enzyme and pathway databases

BioCyciTUZO999630:G1GSD-358-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR017721 Indolepyruvate_Fd_OxRdtase_asu
IPR002880 Pyrv_Fd/Flavodoxin_OxRdtase_N
IPR029061 THDP-binding
IPR011766 TPP_enzyme-bd_C
IPR009014 Transketo_C/PFOR_II
PfamiView protein in Pfam
PF00037 Fer4, 1 hit
PF01855 POR_N, 1 hit
PF02775 TPP_enzyme_C, 1 hit
PIRSFiPIRSF006439 Indolepyruvate_ferr_oxidored, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
SSF52922 SSF52922, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiF2L2S1_THEU7
AccessioniPrimary (citable) accession number: F2L2S1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: October 10, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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