Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribulose bisphosphate carboxylase

Gene

rbcL

Organism
Archaeoglobus veneficus (strain DSM 11195 / SNP6)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.UniRule annotation

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei151Proton acceptorUniRule annotation1
Binding sitei153SubstrateUniRule annotation1
Metal bindingi177Magnesium; via carbamate groupUniRule annotation1
Metal bindingi179MagnesiumUniRule annotation1
Metal bindingi180MagnesiumUniRule annotation1
Active sitei269Proton acceptorUniRule annotation1
Binding sitei270SubstrateUniRule annotation1
Binding sitei302SubstrateUniRule annotation1
Sitei309Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported, OxidoreductaseUniRule annotation
Biological processCarbon dioxide fixationUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciAVEN693661:G1GSI-780-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotation
Ordered Locus Names:Arcve_0786Imported
OrganismiArchaeoglobus veneficus (strain DSM 11195 / SNP6)Imported
Taxonomic identifieri693661 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000008136 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei177N6-carboxylysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.UniRule annotation

Protein-protein interaction databases

STRINGi693661.Arcve_0786

Structurei

3D structure databases

ProteinModelPortaliF2KRW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 120RuBisCO_large_NInterPro annotationAdd BLAST113
Domaini130 – 409RuBisCO_largeInterPro annotationAdd BLAST280

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni338 – 340Substrate bindingUniRule annotation3
Regioni360 – 363Substrate bindingUniRule annotation4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili187 – 207Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the RuBisCO large chain family. Type III subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiarCOG04443 Archaea
COG1850 LUCA
KOiK01601
OMAiHRAMHAA
OrthoDBiPOG093Z02MJ

Family and domain databases

CDDicd08213 RuBisCO_large_III, 1 hit
Gene3Di3.20.20.110, 1 hit
3.30.70.150, 1 hit
HAMAPiMF_01133 RuBisCO_L_type3, 1 hit
InterProiView protein in InterPro
IPR033966 RuBisCO
IPR017712 RuBisCO_III
IPR020878 RuBisCo_large_chain_AS
IPR000685 RuBisCO_lsu_C
IPR036376 RuBisCO_lsu_C_sf
IPR017443 RuBisCO_lsu_fd_N
IPR036422 RuBisCO_lsu_N_sf
PfamiView protein in Pfam
PF00016 RuBisCO_large, 1 hit
PF02788 RuBisCO_large_N, 1 hit
SFLDiSFLDS00014 RuBisCO, 1 hit
SUPFAMiSSF51649 SSF51649, 1 hit
SSF54966 SSF54966, 1 hit
TIGRFAMsiTIGR03326 rubisco_III, 1 hit
PROSITEiView protein in PROSITE
PS00157 RUBISCO_LARGE, 1 hit

Sequencei

Sequence statusi: Complete.

F2KRW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFEWYTEFV DLSYEPEENE IICVFRVEPD GISMEEAAGR VASESSVGTW
60 70 80 90 100
TTLAKLPERI KRLMAKVFEI DGNVVKIAYP LDLFEEGSIP QLLSSVAGNV
110 120 130 140 150
FGMKALKNLR LEDIEFPAEY CKHFSGPLLG IEGVRKLFGV YDRPLTATVP
160 170 180 190 200
KPKVGFDADE YADIAYQGWS GGIDFIKDDE NLTSQPFVRF EKRLEKVMKA
210 220 230 240 250
REKAEKETGE KKVYLANVTA VGKEMLRRAK LVADYGNEYV MVDILTAGFS
260 270 280 290 300
AVQMLREECE DLGLGIHAHR AMHAAFTRNP KHGISLDVLV KISRLAGVDN
310 320 330 340 350
FHVGTGVGKM EGSKDMVKRL ADICRREWYV KPVFPVSSGG LHPGLVPDIV
360 370 380 390 400
QLFGKDVIIQ AGGGVHGHPD GTHAGAKALR QAIDAVIKGI SLDEHAKKHA
410
ELARALEKWG YTRPK
Length:415
Mass (Da):45,962
Last modified:May 31, 2011 - v1
Checksum:i74680EC3F2F95AF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002588 Genomic DNA Translation: AEA46802.1
RefSeqiWP_013683474.1, NC_015320.1

Genome annotation databases

EnsemblBacteriaiAEA46802; AEA46802; Arcve_0786
GeneIDi10393889
KEGGiave:Arcve_0786

Similar proteinsi

Entry informationi

Entry nameiF2KRW1_ARCVS
AccessioniPrimary (citable) accession number: F2KRW1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: February 28, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health