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Entry version 49 (11 Dec 2019)
Sequence version 1 (31 May 2011)
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Protein
Submitted name:

DmX-like protein 1

Gene

DMXL1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
F1T0K4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DmX-like protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DMXL1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
F1T0K4

PRoteomics IDEntifications database

More...
PRIDEi
F1T0K4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2709 – 2792WD_REPEATS_REGIONInterPro annotationAdd BLAST84
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati2751 – 2792WDPROSITE-ProRule annotationAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni247 – 277DisorderedSequence analysisAdd BLAST31
Regioni390 – 411DisorderedSequence analysisAdd BLAST22
Regioni2194 – 2239DisorderedSequence analysisAdd BLAST46
Regioni2273 – 2295DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2281 – 2295AcidicSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1064 Eukaryota
ENOG410XPUM LUCA

Database of Orthologous Groups

More...
OrthoDBi
127808at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022033 Rav1p_C
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12234 Rav1p_C, 2 hits
PF00400 WD40, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1T0K4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFSPDGEFF ATAGKDDCLL KVWYNVENWR TAVTSPDGSS EKQSQGEIDF
60 70 80 90 100
SFVYLAHPRA VNGFSWRKTS KYMPRASVCN VLLTCCKDNV CRLWVETFLP
110 120 130 140 150
NDCLLYGGDC SHWTESINLT NNFKRNASSK ERVQNALEVN LRHFRRGRRR
160 170 180 190 200
SLALVAHTGY LPHQQDPHHV HRNTPLHANA LCHFHIAASI NPATDIPLLP
210 220 230 240 250
SITSLSLNEN EEKTGPFVVH WLNNKELHFT LSMEVFLQQL RKSFEQPSSE
260 270 280 290 300
ASVEDSNQAD VKSDEETDDG VDDLKINPEK KELGCDKMVP NSSFTSLSSA
310 320 330 340 350
AIDHQIEVLL SEWSKNADML FSIHPMDGSL LVWHVDWLDE YQPGMFRQVQ
360 370 380 390 400
VSFVSRIPVA FPTGDANSLC KSIMMYACTK NVDLAIQQGK QKPSGLTRST
410 420 430 440 450
SMLISSGHNK SSNSLKLSIF TPNVMMISKH ADGSLNQWLV SFAEESAFST
460 470 480 490 500
VLSISHKSRY CGHRFHLNDL ACHSVLPLLL TTSHHNALRT PDVDNPEQPF
510 520 530 540 550
DALNIEECSL TQQNKSTVDV AFQDPSAVYS ELILWRVDPV GPLSFSGGVS
560 570 580 590 600
ELARINSLHV SAFSNVAWLP TLIPSYCLGA YCNSPSACFV ASDGQYLRLY
610 620 630 640 650
EAVIDAKKLL SELSNPEISK YVGEVFNIVS QQSTARPGCI IALDPITKLH
660 670 680 690 700
GRKTQLLHVF EEDFILNNLE KKSLGKDSIL SNAGSSPNGF SEKFYLIVIE
710 720 730 740 750
CTQDNRSLLH MWNLHLKSIP VSLDEKVDTK LSEAVWQPEE HYSSSPEKIL
760 770 780 790 800
SPFSQKYQAC RANLQSTSRL TLFSEMVYSQ ELHLPEGVEI ISIKPSAGHL
810 820 830 840 850
SSSSIYPACS APYLLATSCS DEKVRFWRCR VTDGESATSK NGKIDLAYIW
860 870 880 890 900
EEWPLLIEDG LQSNSSITVP GRPVEVSCAH TNRLAVAYKQ PASNSRSSQD
910 920 930 940 950
FVMHVSIFEC ESTGGSCWVL EQTIHLDELS TVLDSGISVD SNLVAYNKQD
960 970 980 990 1000
MYLSSKENIT SNTKHLVHLD WMSREDGSHI LTVGIGSKLF MYGPLAGKVQ
1010 1020 1030 1040 1050
DQTGKETLAF PLWESTKVVP LSKFVLLRSV DLVSSVDGSP PFPVSLSWVR
1060 1070 1080 1090 1100
DGILVVGMDC EMHVYCQWQP SSKQEPVITD SYSGSTPSIT SLIKQSNSSS
1110 1120 1130 1140 1150
GLHPPKKTLT RSMTSLAQKI CGKKTAFDPS VDMEDSGLFE AAHVLSPTLP
1160 1170 1180 1190 1200
QYHPLQLLEL MDLGKVRRAK AILSHLVKCI AGEVVALNEA ESNHERRLRS
1210 1220 1230 1240 1250
LTISASGSTT RDPQAFNKAE NTDYTEIDSV PPLPLYALLA ADDDSCYSSL
1260 1270 1280 1290 1300
EKSSNESTLS KSNQLSKESY DELFQTQLLM TDTHMLETDE ENTKPRVIDL
1310 1320 1330 1340 1350
SQYSPTYFGP EHAQVLSGHL LHSSLPGLSR MEQMSLMALA DTIATTSTDI
1360 1370 1380 1390 1400
GESRDRSQGG ETLDECGLKF LLAVRLHTFL TTSLPAYRAQ LLHQGLSTSH
1410 1420 1430 1440 1450
FAWAFHSVAE EELLNMLPAM QKDDPTWSEL RAMGVGWWVR NTRILRKCIE
1460 1470 1480 1490 1500
KVAKAAFYRK NDPLDAAIFY LAMKKKAVIW GLYRAEKNTR MTQFFGHNFE
1510 1520 1530 1540 1550
DERWRKAALK NAFSLLGKQR FEHSAAFFLL AGCLRDAIEV CLEKLNDIQL
1560 1570 1580 1590 1600
ALVIARLYES EFDTSAAYKS ILRKKVLGID SPVSELCSLN INMHHDPFLR
1610 1620 1630 1640 1650
SMAYWILEDY SGALETLIKQ PIRENDDQVL SASNPTVFNF YNYLRTHPLL
1660 1670 1680 1690 1700
LRRHFGSSDT FSTHMSLTGK SGLAGTINLS ERRLFFTTAS AHLKAGCPML
1710 1720 1730 1740 1750
ALEVLSKMPK VIKKTRPFYR ASSFLDTSKD CSPSSPLKLD AREDKSSAVD
1760 1770 1780 1790 1800
WSQSLINGFG SSSEGSSEKQ SNSTLSFDWS QPSVVFQDDS LELKWDSDND
1810 1820 1830 1840 1850
EENEDVPISM KELKPLQRKT DKKLDDISSN YTESFSTLDE NDLLNPSEDI
1860 1870 1880 1890 1900
IAVQLKFRAC LKILTVELRT LSTGYEIDGG KLRYQLYHWL EKEVIALQRT
1910 1920 1930 1940 1950
CDFCSDAEEL QSAFGRNEDE FGLNEDAEDL PHQTKVKQLR ENFQEKRQWL
1960 1970 1980 1990 2000
LKYQSLLRMF LSYCILHGSH GGGLASVRME LILLLQESQQ ETSEPLFSSP
2010 2020 2030 2040 2050
LSEQTSVPLL FACTANAKTV VANPLLHLSN LTHDILHAII NFDSPPHPDI
2060 2070 2080 2090 2100
QSNKVYVMHT LAASLSACIY QCLCGSHNYS SFQTNQFTGM VYQTVLLPHR
2110 2120 2130 2140 2150
PSLKTGSLDE ALTPNTSPAQ WPGITCLIRL LNSSGEEAQS GLTVLLCEIL
2160 2170 2180 2190 2200
TAVYLSLFIH GLATHSSNEL FRIVAHPLNE KMWSAVFGGG AHVPSKEQTH
2210 2220 2230 2240 2250
SKTLPVSSLV EEGEKQNKRF RPSKMSCRES APLTPSSAPV SQESLAVKEK
2260 2270 2280 2290 2300
FIPPELSIWD YFIAKPFLPS SQSRAEYDSE ESLGSDDDDN DDDDDVLASD
2310 2320 2330 2340 2350
FHLQEHSNSN SYSWSLMRLA MVQLVLNNLK TFYPFAGHDL AELPVSSPLC
2360 2370 2380 2390 2400
HAVLKTLQCW EQVLLRRLEI HGGPPQNYIA SHTAEESLSA GPAILRHKAL
2410 2420 2430 2440 2450
LEPTNTPFKS KHHLALSVKR LWQYLVKQEE IQETFIKNIF TKKRCLNEIE
2460 2470 2480 2490 2500
ADLGYPGGKA RIIHKESDII TAFAVNKANR NCIAIASSHD VQELDVSGIL
2510 2520 2530 2540 2550
ATQVYTWVDD DIEVETKGSE DFLVIHARDD LTAVQGTTPY THSNPGTPIN
2560 2570 2580 2590 2600
MPWLGSTQTG RGASVMIKKA INNVRRMTSH PTLPYYLTGA QDGSVRMFEW
2610 2620 2630 2640 2650
GHSQQITCFR SGGNSRVTRM RFNYQGNKFG IVDADGYLSL YQTNWKCCPV
2660 2670 2680 2690 2700
TGSMPKPYLT WQCHNKTAND FVFVSSSSLI ATAGLSTDNR NVCLWDTLVA
2710 2720 2730 2740 2750
PANSLVHAFT CHDSGATVLA YAPKHQLLIS GGRKGFTYVF DLCQRQQRQL
2760 2770 2780 2790 2800
FQSHDSPVKA VAVDPTEEYF VTGSAEGNIK IWSLSTFGLL HTFVSEHARQ
2810 2820 2830 2840 2850
SIFRNIGTGV MQIETGPANH IFSCGADGTM KMRILPDQFS PLNEVLKNDV

KFML
Length:2,854
Mass (Da):318,640
Last modified:May 31, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C12F8784F583043
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB593142 mRNA Translation: BAJ84078.1

NCBI Reference Sequences

More...
RefSeqi
NP_001277250.1, NM_001290321.2
NP_001277251.1, NM_001290322.2
NP_005500.4, NM_005509.5

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1657

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1657

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB593142 mRNA Translation: BAJ84078.1
RefSeqiNP_001277250.1, NM_001290321.2
NP_001277251.1, NM_001290322.2
NP_005500.4, NM_005509.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiF1T0K4
PRIDEiF1T0K4

Genome annotation databases

GeneIDi1657
KEGGihsa:1657

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1657

Phylogenomic databases

eggNOGiKOG1064 Eukaryota
ENOG410XPUM LUCA
OrthoDBi127808at2759

Enzyme and pathway databases

SignaLinkiF1T0K4

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DMXL1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1657

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR022033 Rav1p_C
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12234 Rav1p_C, 2 hits
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 8 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1T0K4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1T0K4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: December 11, 2019
This is version 49 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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