UniProtKB - F1T0J1 (F1T0J1_HUMAN)
Protein
Submitted name:
Growth/differentiation factor 5
Gene
GDF5
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
GO - Biological processi
- embryonic limb morphogenesis Source: Ensembl
- forelimb morphogenesis Source: Ensembl
- hindlimb morphogenesis Source: Ensembl
- negative regulation of mesenchymal cell apoptotic process Source: Ensembl
- negative regulation of neuron apoptotic process Source: Ensembl
- ossification involved in bone remodeling Source: Ensembl
- positive regulation of chondrocyte differentiation Source: Ensembl
- positive regulation of neuron differentiation Source: Ensembl
- regulation of multicellular organism growth Source: Ensembl
- response to mechanical stimulus Source: Ensembl
- transmembrane receptor protein serine/threonine kinase signaling pathway Source: Ensembl
Keywordsi
Molecular function | Growth factorUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Growth/differentiation factor 5Imported |
Gene namesi | Name:GDF5Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000125965.8 |
Subcellular locationi
Extracellular region or secreted
- extracellular region Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_5003275837 | 28 – 501 | Sequence analysisAdd BLAST | 474 |
Expressioni
Gene expression databases
Bgeei | ENSG00000125965, Expressed in saliva-secreting gland and 124 other tissues |
ExpressionAtlasi | F1T0J1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 378 – 501 | TGF_BETA_2InterPro annotationAdd BLAST | 124 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 29 – 169 | DisorderedSequence analysisAdd BLAST | 141 | |
Regioni | 246 – 265 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_020515_0_0_1 |
OMAi | PKARCSR |
OrthoDBi | 749511at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
F1T0J1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLPKLLTFL LWYLAWLDLE FICTVLGAPD LGQRPQGTRP GLAKAEAKER
60 70 80 90 100
PPLARNVFRP GGHSYGGGAT NANARAKGGT GQTGGLTQPK KDEPKKLPPR
110 120 130 140 150
PGGPEPKPGH PPQTRQATAR TVTPKGQLPG GKAPPKAGSV PSSFLLKKAR
160 170 180 190 200
EPGPPREPKE PFRPPPITPH EYMLSLYRTL SDADRKGGNS SVKLEAGLAN
210 220 230 240 250
TITSFIDKGQ DDRGPVVRKQ RYVFDISALE KDGLLGAELR ILRKKPSDTA
260 270 280 290 300
KPAAPGGGRA AQLKLSSCPS GRQPAALLDV RSVPGLDGSG WEVFDIWKLF
310 320 330 340 350
RNFKNSAQLC LELEAWERGR AVDLRGLGFD RAARQVHEKA LFLVFGRTKK
360 370 380 390 400
RDLFFNEIKA RSGQDDKTVY EYLFSQRRKR RAPLATRQGK RPSKNLKARC
410 420 430 440 450
SRKALHVNFK DMGWDDWIIA PLEYEAFHCE GLCEFPLRSH LEPTNHAVIQ
460 470 480 490 500
TLMNSMDPES TPPTCCVPTR LSPISILFID SANNVVYKQY EDMVVESCGC
R
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB593125 mRNA Translation: BAJ84065.1 |
RefSeqi | NP_000548.2, NM_000557.4 NP_001306067.1, NM_001319138.1 XP_011527377.1, XM_011529075.2 |
Genome annotation databases
GeneIDi | 8200 |
KEGGi | hsa:8200 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB593125 mRNA Translation: BAJ84065.1 |
RefSeqi | NP_000548.2, NM_000557.4 NP_001306067.1, NM_001319138.1 XP_011527377.1, XM_011529075.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 2854, 408 antibodies |
DNASUi | 8200 |
Genome annotation databases
GeneIDi | 8200 |
KEGGi | hsa:8200 |
Organism-specific databases
CTDi | 8200 |
VEuPathDBi | HostDB:ENSG00000125965.8 |
Phylogenomic databases
HOGENOMi | CLU_020515_0_0_1 |
OMAi | PKARCSR |
OrthoDBi | 749511at2759 |
Miscellaneous databases
BioGRID-ORCSi | 8200, 7 hits in 984 CRISPR screens |
GenomeRNAii | 8200 |
Gene expression databases
Bgeei | ENSG00000125965, Expressed in saliva-secreting gland and 124 other tissues |
ExpressionAtlasi | F1T0J1, baseline and differential |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1T0J1_HUMAN | |
Accessioni | F1T0J1Primary (citable) accession number: F1T0J1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 31, 2011 |
Last sequence update: | May 31, 2011 | |
Last modified: | April 7, 2021 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |