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UniProtKB - F1T0F8 (F1T0F8_HUMAN)
Protein
Submitted name:
Paired box protein Pax-6
Gene
PAX6
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 224 – 283 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- chromatin binding Source: Ensembl
- co-SMAD binding Source: Ensembl
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
- histone acetyltransferase binding Source: Ensembl
- HMG box domain binding Source: Ensembl
- protein kinase binding Source: Ensembl
- RNA binding Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
- RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
- R-SMAD binding Source: Ensembl
- transcription coregulator binding Source: Ensembl
- ubiquitin protein ligase binding Source: Ensembl
GO - Biological processi
- astrocyte differentiation Source: Ensembl
- axon guidance Source: Ensembl
- cell fate determination Source: Ensembl
- cellular response to leukemia inhibitory factor Source: Ensembl
- cerebral cortex regionalization Source: Ensembl
- commitment of neuronal cell to specific neuron type in forebrain Source: Ensembl
- dorsal/ventral axis specification Source: Ensembl
- embryonic camera-type eye morphogenesis Source: Ensembl
- establishment of mitotic spindle orientation Source: Ensembl
- eye photoreceptor cell development Source: Ensembl
- forebrain dorsal/ventral pattern formation Source: Ensembl
- forebrain-midbrain boundary formation Source: Ensembl
- gene expression Source: Ensembl
- habenula development Source: Ensembl
- keratinocyte differentiation Source: Ensembl
- lacrimal gland development Source: Ensembl
- lens development in camera-type eye Source: Ensembl
- negative regulation of epithelial cell proliferation Source: Ensembl
- negative regulation of neural precursor cell proliferation Source: Ensembl
- negative regulation of neuron differentiation Source: Ensembl
- negative regulation of protein phosphorylation Source: Ensembl
- neuron migration Source: Ensembl
- oligodendrocyte cell fate specification Source: Ensembl
- pancreatic A cell development Source: Ensembl
- pituitary gland development Source: Ensembl
- positive regulation of epithelial cell differentiation Source: Ensembl
- positive regulation of gene expression Source: Ensembl
- positive regulation of neuroblast proliferation Source: Ensembl
- protein localization to organelle Source: Ensembl
- regulation of asymmetric cell division Source: Ensembl
- regulation of cell migration Source: Ensembl
- regulation of timing of cell differentiation Source: Ensembl
- retina development in camera-type eye Source: Ensembl
- salivary gland morphogenesis Source: Ensembl
- signal transduction involved in regulation of gene expression Source: Ensembl
- smoothened signaling pathway Source: Ensembl
- type B pancreatic cell differentiation Source: Ensembl
- ventral spinal cord development Source: Ensembl
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Paired box protein Pax-6Imported |
Gene namesi | Name:PAX6Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000007372 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotationARBA annotation
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- chromatin Source: Ensembl
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000007372, Expressed in palpebral conjunctiva and 174 other tissues |
Interactioni
GO - Molecular functioni
- co-SMAD binding Source: Ensembl
- histone acetyltransferase binding Source: Ensembl
- HMG box domain binding Source: Ensembl
- protein kinase binding Source: Ensembl
- R-SMAD binding Source: Ensembl
- transcription coregulator binding Source: Ensembl
- ubiquitin protein ligase binding Source: Ensembl
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 144 | PairedInterPro annotationAdd BLAST | 141 | |
Domaini | 222 – 282 | HomeoboxInterPro annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 176 – 215 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 283 – 325 | DisorderedSequence analysisAdd BLAST | 43 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 222 – 242 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 181 – 213 | Polar residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 290 – 325 | Polar residuesSequence analysisAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the paired homeobox family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, HomeoboxPROSITE-ProRule annotationARBA annotation, Paired boxARBA annotationPhylogenomic databases
OMAi | RSEYHNQ |
OrthoDBi | 1152885at2759 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit cd00131, PAX, 1 hit |
Gene3Di | 1.10.10.10, 2 hits |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR001523, Paired_dom IPR043565, PAX_fam IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR45636, PTHR45636, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF00292, PAX, 1 hit |
PRINTSi | PR00027, PAIREDBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00351, PAX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS51057, PAIRED_2, 1 hit |
i Sequence
Sequence statusi: Complete.
F1T0F8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQNSHSGVNQ LGGVFVNGRP LPDSTRQKIV ELAHSGARPC DISRILQTHA
60 70 80 90 100
DAKVQVLDNQ NVSNGCVSKI LGRYYETGSI RPRAIGGSKP RVATPEVVSK
110 120 130 140 150
IAQYKRECPS IFAWEIRDRL LSEGVCTNDN IPSVSSINRV LRNLASEKQQ
160 170 180 190 200
MGADGMYDKL RMLNGQTGSW GTRPGWYPGT SVPGQPTQDG CQQQEGGGEN
210 220 230 240 250
TNSISSNGED SDEAQMRLQL KRKLQRNRTS FTQEQIEALE KEFERTHYPD
260 270 280 290 300
VFARERLAAK IDLPEARIQV WFSNRRAKWR REEKLRNQRR QASNTPSHIP
310 320 330 340 350
ISSSFSTSVY QPIPQPTTPV SSFTSGSMLG RTDTALTNTY SALPPMPSFT
360 370 380 390 400
MANNLPMQPP VPSQTSSYSC MLPTSPSVNG RSYDTYTPPH MQTHMNSQPM
410 420 430
GTSGTTSTGL ISPGVSVPVQ VPGSEPDMSQ YWPRLQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB593092 mRNA Translation: BAJ84032.1 AB593093 mRNA Translation: BAJ84033.1 AB593094 mRNA Translation: BAJ84034.1 |
RefSeqi | NP_001245391.1, NM_001258462.1 NP_001245392.1, NM_001258463.1 NP_001297087.1, NM_001310158.1 NP_001595.2, NM_001604.5 |
Genome annotation databases
GeneIDi | 5080 |
MANE-Selecti | ENST00000640368.2; ENSP00000492024.1; NM_001368894.2; NP_001355823.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB593092 mRNA Translation: BAJ84032.1 AB593093 mRNA Translation: BAJ84033.1 AB593094 mRNA Translation: BAJ84034.1 |
RefSeqi | NP_001245391.1, NM_001258462.1 NP_001245392.1, NM_001258463.1 NP_001297087.1, NM_001310158.1 NP_001595.2, NM_001604.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 12821, 927 antibodies from 49 providers |
DNASUi | 5080 |
Genome annotation databases
GeneIDi | 5080 |
MANE-Selecti | ENST00000640368.2; ENSP00000492024.1; NM_001368894.2; NP_001355823.1 |
Organism-specific databases
CTDi | 5080 |
VEuPathDBi | HostDB:ENSG00000007372 |
Phylogenomic databases
OMAi | RSEYHNQ |
OrthoDBi | 1152885at2759 |
Miscellaneous databases
BioGRID-ORCSi | 5080, 7 hits in 1059 CRISPR screens |
ChiTaRSi | PAX6, human |
GenomeRNAii | 5080 |
Gene expression databases
Bgeei | ENSG00000007372, Expressed in palpebral conjunctiva and 174 other tissues |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit cd00131, PAX, 1 hit |
Gene3Di | 1.10.10.10, 2 hits |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR001523, Paired_dom IPR043565, PAX_fam IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR45636, PTHR45636, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF00292, PAX, 1 hit |
PRINTSi | PR00027, PAIREDBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00351, PAX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS51057, PAIRED_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | F1T0F8_HUMAN | |
Accessioni | F1T0F8Primary (citable) accession number: F1T0F8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 31, 2011 |
Last sequence update: | May 31, 2011 | |
Last modified: | January 19, 2022 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |