UniProtKB - F1T0D1 (F1T0D1_HUMAN)
Protein
Submitted name:
Homeobox protein OTX2
Gene
OTX2
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 46 – 105 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotationImportedARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Homeobox protein OTX2ImportedSubmitted name: Orthodenticle homolog 2 (Drosophila), isoform CRA_bImported |
Gene namesi | Name:OTX2Imported ORF Names:hCG_32530Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000165588.16 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000165588, Expressed in pigmented layer of retina and 52 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 104 | HomeoboxInterPro annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 101 – 151 | DisorderedSequence analysisAdd BLAST | 51 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 101 – 117 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 128 – 151 | PolarSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Keywords - Domaini
HomeoboxPROSITE-ProRule annotationImportedARBA annotationPhylogenomic databases
OMAi | LPTQGYG |
OrthoDBi | 1481439at2759 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR003022, Otx2_TF IPR003025, Otx_TF IPR013851, Otx_TF_C |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03529, TF_Otx, 1 hit |
PRINTSi | PR01257, OTX2HOMEOBOX PR01255, OTXHOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
F1T0D1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMSYLKQPPY AVNGLSLTTS GMDLLHPSVG YPGPWASCPA ATPRKQRRER
60 70 80 90 100
TTFTRAQLDV LEALFAKTRY PDIFMREEVA LKINLPESRV QVWFKNRRAK
110 120 130 140 150
CRQQQQQQQN GGQNKVRPAK KKTSPAREVS SESGTSGQFT PPSSTSVPTI
160 170 180 190 200
ASSSAPVSIW SPASISPLSD PLSTSSSCMQ RSYPMTYTQA SGYSQGYAGS
210 220 230 240 250
TSYFGGMDCG SYLTPMHHQL PGPGATLSPM GTNAVTSHLN QSPASLSTQG
260 270 280 290
YGASSLGFNS TTDCLDYKDQ TASWKLNFNA DCLDYKDQTS SWKFQVL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB593058 mRNA Translation: BAJ84005.1 CH471061 Genomic DNA Translation: EAW80693.1 |
RefSeqi | NP_001257452.1, NM_001270523.1 NP_001257453.1, NM_001270524.1 NP_001257454.1, NM_001270525.1 NP_068374.1, NM_021728.3 |
Genome annotation databases
GeneIDi | 5015 |
KEGGi | hsa:5015 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB593058 mRNA Translation: BAJ84005.1 CH471061 Genomic DNA Translation: EAW80693.1 |
RefSeqi | NP_001257452.1, NM_001270523.1 NP_001257453.1, NM_001270524.1 NP_001257454.1, NM_001270525.1 NP_068374.1, NM_021728.3 |
3D structure databases
SMRi | F1T0D1 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 49, 404 antibodies |
DNASUi | 5015 |
Genome annotation databases
GeneIDi | 5015 |
KEGGi | hsa:5015 |
Organism-specific databases
CTDi | 5015 |
EuPathDBi | HostDB:ENSG00000165588.16 |
Phylogenomic databases
OMAi | LPTQGYG |
OrthoDBi | 1481439at2759 |
Miscellaneous databases
BioGRID-ORCSi | 5015, 13 hits in 865 CRISPR screens |
GenomeRNAii | 5015 |
Gene expression databases
Bgeei | ENSG00000165588, Expressed in pigmented layer of retina and 52 other tissues |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR003022, Otx2_TF IPR003025, Otx_TF IPR013851, Otx_TF_C |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03529, TF_Otx, 1 hit |
PRINTSi | PR01257, OTX2HOMEOBOX PR01255, OTXHOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1T0D1_HUMAN | |
Accessioni | F1T0D1Primary (citable) accession number: F1T0D1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 31, 2011 |
Last sequence update: | May 31, 2011 | |
Last modified: | December 2, 2020 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |