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Entry version 48 (05 Jun 2019)
Sequence version 3 (22 Nov 2017)
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Protein
Submitted name:

FAST kinase domain-containing protein 4

Gene

TBRG4

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseImported, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FAST kinase domain-containing protein 4Imported
Submitted name:
FAST kinase domain-containing protein 4 isoform 1Imported
Submitted name:
Protein TBRG4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TBRG4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1ST63

PeptideAtlas

More...
PeptideAtlasi
F1ST63

PRoteomics IDEntifications database

More...
PRIDEi
F1ST63

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSSSCG00000021566 Expressed in 5 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1ST63 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini562 – 620RAPInterPro annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni24 – 53DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi34 – 52PolarSequence analysisAdd BLAST19

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEJA Eukaryota
ENOG4111EYX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182779

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1ST63

Identification of Orthologs from Complete Genome Data

More...
OMAi
ELRWTEI

Database of Orthologous Groups

More...
OrthoDBi
1209476at2759

TreeFam database of animal gene trees

More...
TreeFami
TF324885

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013579 FAST_2
IPR010622 FAST_Leu-rich
IPR013584 RAP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06743 FAST_1, 1 hit
PF08368 FAST_2, 1 hit
PF08373 RAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00952 RAP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51286 RAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F1ST63-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASRLVRRCT CLLREAARLA PAMSPVGQPR LTRGAPRTLT SSATSPSSHL
60 70 80 90 100
PGSLSELVER GQVFTPYPER QEVDHLIERA TQPEEILALL GGGHCLHQNR
110 120 130 140 150
AALMVIQLSR LLSEKPKDKA LLIKDARFQH LLRLVNSQIN AVWHGTLVKL
160 170 180 190 200
LRSLYALGLP ATSKELQSVE QEVRWRMRRL RYKHLAFLAE SSATYMQEQG
210 220 230 240 250
SQELLAELLV HLERRWTEID DGRTVVAMMV KIGHLSQSLM NRLEDKCLEL
260 270 280 290 300
VEQFGPEELR KVLVMLAAQN RRSVPLLRAV SYHLVQKPFT LTKSILLDLA
310 320 330 340 350
YAYGKLGFHQ TQVFQRLAAD LLPHTPSLTS SEVARCTKSF AFLKWLSLPL
360 370 380 390 400
FEAFAQHVLD RAQSIALPHL CNMLLAFARV NFRPEREDQF FSLVHEKLGS
410 420 430 440 450
QLAGLEPALQ VDVVWSLCVL QQAREAELQA VLRPELHGQF LGDKSPKDQS
460 470 480 490 500
TFQKLLHINA TAQLEHPEYT GPHLPSSALV PRPSALDKKV TPLQKELQET
510 520 530 540 550
LKGLLGSANK GSFLVATRYG WILDAEVLLD ADSQLLPLRD FVAPHLAQPS
560 570 580 590 600
GSQPLPAGAK RLAFLCWEFP NFNSRSKDLL GRFVLARRHL LAAGFLLVDV
610 620 630
PYYEWLELKS EWQKSAYLKD KMRKAVAEEL AK
Length:632
Mass (Da):71,247
Last modified:November 22, 2017 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D6CAA0E55E3599A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1ST64F1ST64_PIG
FAST kinase domain-containing prote...
TBRG4
594Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1ST47F1ST47_PIG
FAST kinase domain-containing prote...
TBRG4
522Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEMK02000111 Genomic DNA No translation available.
DQIR01084126 Transcribed RNA Translation: HDA39602.1
DQIR01084573 Transcribed RNA Translation: HDA40049.1
DQIR01087102 Transcribed RNA Translation: HDA42578.1
DQIR01163315 Transcribed RNA Translation: HDB18792.1
DQIR01182517 Transcribed RNA Translation: HDB37994.1

NCBI Reference Sequences

More...
RefSeqi
NP_001116573.2, NM_001123101.2
XP_005673389.1, XM_005673332.1
XP_005673390.1, XM_005673333.2
XP_013841255.1, XM_013985801.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00000018214; ENSSSCP00000017723; ENSSSCG00000016732

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
397641

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ssc:397641

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000111 Genomic DNA No translation available.
DQIR01084126 Transcribed RNA Translation: HDA39602.1
DQIR01084573 Transcribed RNA Translation: HDA40049.1
DQIR01087102 Transcribed RNA Translation: HDA42578.1
DQIR01163315 Transcribed RNA Translation: HDB18792.1
DQIR01182517 Transcribed RNA Translation: HDB37994.1
RefSeqiNP_001116573.2, NM_001123101.2
XP_005673389.1, XM_005673332.1
XP_005673390.1, XM_005673333.2
XP_013841255.1, XM_013985801.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF1ST63
PeptideAtlasiF1ST63
PRIDEiF1ST63

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000018214; ENSSSCP00000017723; ENSSSCG00000016732
GeneIDi397641
KEGGissc:397641

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9238

Phylogenomic databases

eggNOGiENOG410IEJA Eukaryota
ENOG4111EYX LUCA
GeneTreeiENSGT00950000182779
InParanoidiF1ST63
OMAiELRWTEI
OrthoDBi1209476at2759
TreeFamiTF324885

Gene expression databases

BgeeiENSSSCG00000021566 Expressed in 5 organ(s), highest expression level in liver
ExpressionAtlasiF1ST63 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR013579 FAST_2
IPR010622 FAST_Leu-rich
IPR013584 RAP
PfamiView protein in Pfam
PF06743 FAST_1, 1 hit
PF08368 FAST_2, 1 hit
PF08373 RAP, 1 hit
SMARTiView protein in SMART
SM00952 RAP, 1 hit
PROSITEiView protein in PROSITE
PS51286 RAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1ST63_PIG
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1ST63
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 22, 2017
Last modified: June 5, 2019
This is version 48 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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