UniProtKB - F1SPV3 (F1SPV3_PIG)
Protein
Nuclear receptor DAX-1
Gene
NR0B1
Organism
Sus scrofa (Pig)
Status
Functioni
Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.ARBA annotation
GO - Molecular functioni
- DNA hairpin binding Source: Ensembl
- protein domain specific binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
- RNA binding Source: Ensembl
- steroid hormone receptor binding Source: Ensembl
- transcription corepressor activity Source: Ensembl
GO - Biological processi
- adrenal gland development Source: Ensembl
- Leydig cell differentiation Source: Ensembl
- male sex determination Source: Ensembl
- negative regulation of DNA-binding transcription factor activity Source: Ensembl
- negative regulation of intracellular steroid hormone receptor signaling pathway Source: Ensembl
- negative regulation of steroid biosynthetic process Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- protein localization Source: Ensembl
- response to immobilization stress Source: Ensembl
- Sertoli cell differentiation Source: Ensembl
- spermatogenesis Source: Ensembl
Keywordsi
Molecular function | ReceptorARBA annotation, RepressorARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor DAX-1ARBA annotationAlternative name(s): Nuclear receptor subfamily 0 group B member 1ARBA annotation |
Gene namesi | Name:NR0B1Imported |
Organismi | Sus scrofa (Pig)Imported |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
- centriolar satellite Source: Ensembl
Nucleus
- nuclear speck Source: Ensembl
Other locations
- cytoplasm Source: UniProtKB-SubCell
- membrane Source: Ensembl
- polysomal ribosome Source: Ensembl
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSSSCG00000012199, Expressed in testis and 8 other tissues |
Interactioni
GO - Molecular functioni
- protein domain specific binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
- steroid hormone receptor binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 228 – 489 | NR LBDInterPro annotationAdd BLAST | 262 |
Sequence similaritiesi
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00390000015719 |
HOGENOMi | CLU_674314_0_0_1 |
OMAi | WGCSCGA |
TreeFami | TF332386 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR033544, NR0B1/2 IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR025900, Nuclear_receptor_repeat |
PANTHERi | PTHR24081, PTHR24081, 3 hits |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF14046, NR_Repeat, 4 hits |
PRINTSi | PR00398, STRDHORMONER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit |
i Sequence
Sequence statusi: Complete.
F1SPV3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDRRRPLLDR AGLPAQRAMA GEDHQWQGSI LYNMLMSAKQ THATREAPEA
60 70 80 90 100
RLRGSCWGCS CGSEPPVGRE GQPGGPAVAL LYRCCFCGED HPRQGSILYN
110 120 130 140 150
MLTSAKQTQE TPEAPEARLG GACWGCSCGS EPRVGREELP GGRATVLLYR
160 170 180 190 200
CCFCGEEHPR QGSILYSLLT SAKQTHVALE APEARPGGAW WDRSYCAQRL
210 220 230 240 250
GAREELPGGR PVTLPYRCCF CGEDHPRQSG ILCNMPMSAK QTHVAPEAQP
260 270 280 290 300
GAPWWDPSCA AQRRVALKSP QVVCEAASAG LLKTLRFVKY LPCFQVLPLD
310 320 330 340 350
QQLVLVRSCW APLLMLELAQ DRLNFETVET LEPSLLQMIL TTRRQETEGD
360 370 380 390 400
EPPSPQPPVQ PHLVLPSEAE HLPSVAEVQA IKGFLAKCWS LDISTKEYAY
410 420 430 440 450
LKGTVLFNPD LPGLQCVKYI QGLQWGTQQI LSEHIRMTHR GYQARFAELN
460 470 480 490
SALFLLRFIN ANVLAELFFR PIIGTVSMDD MMLEMLCAKL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AEMK02000112 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSSSCT00000013344; ENSSSCP00000012986; ENSSSCG00000012199 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AEMK02000112 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | F1SPV3 |
Genome annotation databases
Ensembli | ENSSSCT00000013344; ENSSSCP00000012986; ENSSSCG00000012199 |
Phylogenomic databases
GeneTreei | ENSGT00390000015719 |
HOGENOMi | CLU_674314_0_0_1 |
OMAi | WGCSCGA |
TreeFami | TF332386 |
Gene expression databases
Bgeei | ENSSSCG00000012199, Expressed in testis and 8 other tissues |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR033544, NR0B1/2 IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR025900, Nuclear_receptor_repeat |
PANTHERi | PTHR24081, PTHR24081, 3 hits |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF14046, NR_Repeat, 4 hits |
PRINTSi | PR00398, STRDHORMONER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1SPV3_PIG | |
Accessioni | F1SPV3Primary (citable) accession number: F1SPV3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | November 22, 2017 | |
Last modified: | February 10, 2021 | |
This is version 69 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |