Nuclear receptor DAX-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA hairpin binding Source: Ensembl
• protein domain specific binding Source: Ensembl
• protein homodimerization activity Source: Ensembl
• RNA binding Source: Ensembl
• steroid hormone receptor binding Source: Ensembl
• transcription corepressor activity Source: Ensembl

GO - Biological processⁱ

• adrenal gland development Source: Ensembl
• Leydig cell differentiation Source: Ensembl
• male sex determination Source: Ensembl
• negative regulation of DNA-binding transcription factor activity Source: Ensembl
• negative regulation of intracellular steroid hormone receptor signaling pathway Source: Ensembl
• negative regulation of steroid biosynthetic process Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: Ensembl
• protein localization Source: Ensembl
• response to immobilization stress Source: Ensembl
• Sertoli cell differentiation Source: Ensembl
• spermatogenesis Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• protein domain specific binding Source: Ensembl
• protein homodimerization activity Source: Ensembl
• steroid hormone receptor binding Source: Ensembl

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDRRRPLLDR AGLPAQRAMA GEDHQWQGSI LYNMLMSAKQ THATREAPEA 
        60         70         80         90        100
RLRGSCWGCS CGSEPPVGRE GQPGGPAVAL LYRCCFCGED HPRQGSILYN 
       110        120        130        140        150
MLTSAKQTQE TPEAPEARLG GACWGCSCGS EPRVGREELP GGRATVLLYR 
       160        170        180        190        200
CCFCGEEHPR QGSILYSLLT SAKQTHVALE APEARPGGAW WDRSYCAQRL 
       210        220        230        240        250
GAREELPGGR PVTLPYRCCF CGEDHPRQSG ILCNMPMSAK QTHVAPEAQP 
       260        270        280        290        300
GAPWWDPSCA AQRRVALKSP QVVCEAASAG LLKTLRFVKY LPCFQVLPLD 
       310        320        330        340        350
QQLVLVRSCW APLLMLELAQ DRLNFETVET LEPSLLQMIL TTRRQETEGD 
       360        370        380        390        400
EPPSPQPPVQ PHLVLPSEAE HLPSVAEVQA IKGFLAKCWS LDISTKEYAY 
       410        420        430        440        450
LKGTVLFNPD LPGLQCVKYI QGLQWGTQQI LSEHIRMTHR GYQARFAELN 
       460        470        480        490
SALFLLRFIN ANVLAELFFR PIIGTVSMDD MMLEMLCAKL            

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Genome annotation databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ