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Protein
Submitted name:

Hexokinase-2

Gene

HK2

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseSAAS annotation, Transferase
Biological processGlycolysisSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SSC-70171 Glycolysis

Names & Taxonomyi

Protein namesi
Submitted name:
Hexokinase-2Imported
Gene namesi
Name:HK2Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiF1SNW8

Expressioni

Gene expression databases

BgeeiENSSSCG00000008261 Expressed in 4 organ(s), highest expression level in lung

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 219Hexokinase_1InterPro annotationAdd BLAST198
Domaini225 – 459Hexokinase_2InterPro annotationAdd BLAST235
Domaini471 – 667Hexokinase_1InterPro annotationAdd BLAST197
Domaini673 – 907Hexokinase_2InterPro annotationAdd BLAST235

Sequence similaritiesi

Belongs to the hexokinase family.SAAS annotation

Phylogenomic databases

eggNOGiKOG1369 Eukaryota
COG5026 LUCA
GeneTreeiENSGT00390000017159
OrthoDBiEOG091G08MD
TreeFamiTF314238

Family and domain databases

InterProiView protein in InterPro
IPR001312 Hexokinase
IPR019807 Hexokinase_BS
IPR022673 Hexokinase_C
IPR022672 Hexokinase_N
PANTHERiPTHR19443 PTHR19443, 4 hits
PfamiView protein in Pfam
PF00349 Hexokinase_1, 2 hits
PF03727 Hexokinase_2, 2 hits
PROSITEiView protein in PROSITE
PS00378 HEXOKINASE_1, 2 hits
PS51748 HEXOKINASE_2, 2 hits

Sequencei

Sequence statusi: Complete.

F1SNW8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIASHLLAYF FTELNHDQVQ KVDQYLYHMR LSDETLLEIA KRFRKEMEKG
60 70 80 90 100
LGATTHPTAS VKMLPTFVRS TPDGTEHGEF LALDLGGTNF RVLWVRVTDN
110 120 130 140 150
GLQKVEMENQ IYAIPEDIMR GSGTQLFDHI AECLANFMDK LQIKDKKLPL
160 170 180 190 200
GFTFSFPCIQ TKLDESFLVS WTKGFKSSGV EGKDVVTLIR KAIQRRGDFD
210 220 230 240 250
IDIVAVVNDT VGTMMTCGYD DQNCEIGLIV GTGSNACYME EMRHIDMVEG
260 270 280 290 300
DEGRMCINME WGAFGDDGAL DDIRTEFDQE IDMGSLNPGK QLFEKMISGL
310 320 330 340 350
YMGELVRLIL VKMAKEELLF GGKLSPELLA TGHFETKDVS DIEGEKDGIR
360 370 380 390 400
KAREVLVRLG LDPTQEDCVA THRVCQIVST RSASLCAATL AAVLRRIKEN
410 420 430 440 450
KGEERLRSTI GVDGSVYKKH PHFAKRLHKT LRRLVPDCDI RFLRSEDGSG
460 470 480 490 500
KGAAMVTAVA YRLADQHRAR QKTLEPLKLS REQLLEVKRR MKVEMERGLS
510 520 530 540 550
KETHAIAPVK MLPTYVCATP DGTEKGDFLA LDLGGTNFRV LLVRVRNGKR
560 570 580 590 600
RGVEMHNKIY SIPQEVMHGT GDELFDHIVQ CIADFLEYMG VKGVSLPLGF
610 620 630 640 650
TFSFPCQQNS LDESILLKWT KGFKASGCEG EDVVTLLKEA IHRREEFDLD
660 670 680 690 700
VVAVVNDTVG TMMTCGYEDP HCEVGLIVGT GSNACYMEEM RNVELVEGEE
710 720 730 740 750
GRMCVNMEWG AFGDNGCLDD LRTEFDAAVD ELSLNAGKQR FEKMISGMYL
760 770 780 790 800
GEIVRNILID FTKRGLLFRG RISERLKTRG IFETKFLSQI ESDCLALLQV
810 820 830 840 850
RAILHHLGLE STCDDSIIVK EVCTVVARRA AQLCGAGMAA VVDKIRENRG
860 870 880 890 900
LDTLKVTVGV DGTLYKLHPH FAKIMHETVK DLAPKCDVSF LESEDGSGKG
910
AALITAVACR IREAGQR
Length:917
Mass (Da):102,362
Last modified:November 22, 2017 - v3
Checksum:i707C7EA6CB441062
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000021 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSSSCT00000009047; ENSSSCP00000008819; ENSSSCG00000008261

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000021 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiF1SNW8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000009047; ENSSSCP00000008819; ENSSSCG00000008261

Phylogenomic databases

eggNOGiKOG1369 Eukaryota
COG5026 LUCA
GeneTreeiENSGT00390000017159
OrthoDBiEOG091G08MD
TreeFamiTF314238

Enzyme and pathway databases

ReactomeiR-SSC-70171 Glycolysis

Gene expression databases

BgeeiENSSSCG00000008261 Expressed in 4 organ(s), highest expression level in lung

Family and domain databases

InterProiView protein in InterPro
IPR001312 Hexokinase
IPR019807 Hexokinase_BS
IPR022673 Hexokinase_C
IPR022672 Hexokinase_N
PANTHERiPTHR19443 PTHR19443, 4 hits
PfamiView protein in Pfam
PF00349 Hexokinase_1, 2 hits
PF03727 Hexokinase_2, 2 hits
PROSITEiView protein in PROSITE
PS00378 HEXOKINASE_1, 2 hits
PS51748 HEXOKINASE_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiF1SNW8_PIG
AccessioniPrimary (citable) accession number: F1SNW8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 22, 2017
Last modified: September 12, 2018
This is version 52 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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