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UniProtKB - F1SJN6 (F1SJN6_PIG)

Entry version 67 (10 Feb 2021)
Sequence version 2 (22 Nov 2017)
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Protein
Submitted name:

TSC22 domain family member 2

Gene

TSC22D2

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TSC22 domain family member 2Imported
Submitted name:
TSC22 domain family protein 2 isoform 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSC22D2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...VGNCi		VGNC:94482, TSC22D2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		F1SJN6

PRoteomics IDEntifications database

More...PRIDEi		F1SJN6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSSSCG00000011708, Expressed in stomach and 39 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		F1SJN6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		F1SJN6, SS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9823.ENSSSCP00000012480

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 87DisorderedSequence analysisAdd BLAST66
Regioni127 – 158DisorderedSequence analysisAdd BLAST32
Regioni231 – 427DisorderedSequence analysisAdd BLAST197
Regioni481 – 508DisorderedSequence analysisAdd BLAST28
Regioni568 – 612DisorderedSequence analysisAdd BLAST45
Regioni744 – 787DisorderedSequence analysisAdd BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili709 – 743Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi238 – 257PolarSequence analysisAdd BLAST20
Compositional biasi267 – 312Pro-richSequence analysisAdd BLAST46
Compositional biasi574 – 598PolarSequence analysisAdd BLAST25
Compositional biasi744 – 771PolarSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TSC-22/Dip/Bun family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4797, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160465

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020315_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		F1SJN6

Database of Orthologous Groups

More...OrthoDBi		1602203at2759

TreeFam database of animal gene trees

More...TreeFami		TF318837

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000580, TSC-22_Dip_Bun

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01166, TSC22, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01289, TSC22, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1SJN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKMPAKKKS CFQITSVTTA QVATSITEDT ESLDDPDESR TEDVSSEIFD 
        60         70         80         90        100
VSRATDYGPE EVCERSSSEE TLNNVGDAET PGTVSPNLLL DGQLAAAATA 
       110        120        130        140        150
PANGGGALST RSVAGVLAST LASAATSAHS SGAPGVPPVA GPSAGPGTAA 
       160        170        180        190        200
PSQPPTTCSS RFRVIKLDHG SGEPYRRGRW TCMEYYERDS DSSVLTRSGD 
       210        220        230        240        250
CIRHSNTFDQ TAERDSGLGA TGGSVVVVVA SMPGAHGPDS GTDSSLTAVS 
       260        270        280        290        300
QLPPSEKMSQ PAPAPPQSFG VGQPQPQPQP PPVGGAVAPS SAPLPPFPGA 
       310        320        330        340        350
AAGPPQMMAA PPPSQPQGAG HGAVPLGPNG QGLPLTNVTL AQPGLTLPPQ 
       360        370        380        390        400
PGPAVGAAAA QPSQQFAYPQ PHIPPGHLLP VQPAGQSEYL QPHVAGLQPP 
       410        420        430        440        450
SPAQPSTAGA GASPAAAASL PVGTGQNAAS SSVQLMGAPS LPGEAVAPGP 
       460        470        480        490        500
GAVQGAGAAP GLPATVPPAV VGGAVPSGLV PSGQPLPAPP PQMGGSGTPS 
       510        520        530        540        550
TALGAPHAVV PGVPNVPAAA PAPSVPSVST TSVTMPNVPA PLAQTQQLSS 
       560        570        580        590        600
HPPVSRSGSI IQHVGLPLAP GTASAPTSLP QSDLSQFQTQ TQPLVGQVDD 
       610        620        630        640        650
TRRKSESLPQ PPLSLIAENK PVVKPPVADA LANPLQLTPM NSLATSVFSI 
       660        670        680        690        700
AIPVDGDEDR NPSTAFYQAF HLNTIQESKN LWDSASGGGG VAIDNKIEQA 
       710        720        730        740        750
MDLVKSHLMY AVREEVEVLK EQIKELVERN SLLERENALL KSLSNNDQLS 
       760        770        780 
QLPAQQANPG STSQQQAVIA QPPQPTQPPQ QPNVSSA
Length:787
Mass (Da):79,229
Last modified:November 22, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3029347525B76F27
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3LF59I3LF59_PIG
TSC22 domain family member 2
TSC22D2
763Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AEMK02000089 Genomic DNA No translation available.
DQIR01036301 Transcribed RNA Translation: HCZ91776.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSSSCT00000012818; ENSSSCP00000012480; ENSSSCG00000011708

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000089 Genomic DNA No translation available.
DQIR01036301 Transcribed RNA Translation: HCZ91776.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000012480

Proteomic databases

PaxDbiF1SJN6
PRIDEiF1SJN6

Genome annotation databases

EnsembliENSSSCT00000012818; ENSSSCP00000012480; ENSSSCG00000011708

Organism-specific databases

VGNCiVGNC:94482, TSC22D2

Phylogenomic databases

eggNOGiKOG4797, Eukaryota
GeneTreeiENSGT00940000160465
HOGENOMiCLU_020315_0_0_1
InParanoidiF1SJN6
OrthoDBi1602203at2759
TreeFamiTF318837

Gene expression databases

BgeeiENSSSCG00000011708, Expressed in stomach and 39 other tissues
ExpressionAtlasiF1SJN6, baseline and differential
GenevisibleiF1SJN6, SS

Family and domain databases

InterProiView protein in InterPro
IPR000580, TSC-22_Dip_Bun
PfamiView protein in Pfam
PF01166, TSC22, 1 hit
PROSITEiView protein in PROSITE
PS01289, TSC22, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1SJN6_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1SJN6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 22, 2017
Last modified: February 10, 2021
This is version 67 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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