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UniProtKB - F1RY56 (F1RY56_PIG)

Entry version 80 (10 Feb 2021)
Sequence version 1 (03 May 2011)
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Protein
Submitted name:

Cyclin E2

Gene

CCNE2

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclinUniRule annotationARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-SSC-1538133, G0 and Early G1
R-SSC-187577, SCF(Skp2)-mediated degradation of p27/p21
R-SSC-2559586, DNA Damage/Telomere Stress Induced Senescence
R-SSC-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-SSC-69017, CDK-mediated phosphorylation and removal of Cdc6
R-SSC-69200, Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
R-SSC-69202, Cyclin E associated events during G1/S transition
R-SSC-69231, Cyclin D associated events in G1
R-SSC-69563, p53-Dependent G1 DNA Damage Response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cyclin E2Imported
Submitted name:
G1/S-specific cyclin-E2 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCNE2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...VGNCi		VGNC:86355, CCNE2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		F1RY56

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSSSCG00000006095, Expressed in tonsil and 34 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		F1RY56, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9823.ENSSSCP00000006506

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini143 – 174Cyclin N-terminalInterPro annotationAdd BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 46DisorderedSequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi6 – 30PolarSequence analysisAdd BLAST25
Compositional biasi31 – 46PolyampholyteSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0655, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156934

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020695_8_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		F1RY56

Identification of Orthologs from Complete Genome Data

More...OMAi		SWGCSKD

Database of Orthologous Groups

More...OrthoDBi		993640at2759

TreeFam database of animal gene trees

More...TreeFami		TF101005

Family and domain databases

Conserved Domains Database

More...CDDi		cd00043, CYCLIN, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039361, Cyclin
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR004367, Cyclin_C-dom
IPR028858, Cyclin_E
IPR006671, Cyclin_N

The PANTHER Classification System

More...PANTHERi		PTHR10177, PTHR10177, 1 hit
PTHR10177:SF70, PTHR10177:SF70, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001771, Cyclin_A_B_D_E, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00385, CYCLIN, 1 hit
SM01332, Cyclin_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47954, SSF47954, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00292, CYCLINS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1RY56-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRRSSRLQA KQQPQSSQTD SPQEAQIIQT KKRKTTQDVK KRKEEKVTKK 
        60         70         80         90        100
HQYEIRNCWP PVLSGGISPC IIIETPHKEI GTSDFSRFTN YRFKNLFINP 
       110        120        130        140        150
SPLPDLSWGC SQDVWLNMLK KETRYVHDKH FEVLHSDLEP QMRSILLDWL 
       160        170        180        190        200
LEVCEVYTLH RETFYLAQDF FDRFMLTQKD INKNMLQLIG ITSLFIASKL 
       210        220        230        240        250
EEIYAPKLQE FAYVTDGACS EEDILRMELI ILKALKWELC PVTVISWLNL 
       260        270        280        290        300
FLQVDALKDA PKVLLPQYSQ EKFIQIAQLL DLCILAIDSL EFQYRILAAA 
       310        320        330        340        350
ALCHFTSIEV VKKASGLEWD NISECVDWMV PFVSVVKSTS PVKLKIFKKI 
       360        370        380        390        400
SMEDRHNIQT HTNYLAMLDE ANYVNTFRKG GQLSPVCNGG IMTPPKSTEK 

PPAKH
Length:405
Mass (Da):46,806
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD4B6C389DE8261F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A287A1H1A0A287A1H1_PIG
Cyclin E2
CCNE2
375Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AEMK02000022 Genomic DNA No translation available.
DQIR01098251 Transcribed RNA Translation: HDA53727.1

NCBI Reference Sequences

More...RefSeqi		NP_001230860.1, NM_001243931.1
XP_005663015.1, XM_005662958.2
XP_005663016.1, XM_005662959.2
XP_005663017.1, XM_005662960.2
XP_013852050.1, XM_013996596.1
XP_013852051.1, XM_013996597.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSSSCT00000006686; ENSSSCP00000006506; ENSSSCG00000006095

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100512048

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ssc:100512048

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000022 Genomic DNA No translation available.
DQIR01098251 Transcribed RNA Translation: HDA53727.1
RefSeqiNP_001230860.1, NM_001243931.1
XP_005663015.1, XM_005662958.2
XP_005663016.1, XM_005662959.2
XP_005663017.1, XM_005662960.2
XP_013852050.1, XM_013996596.1
XP_013852051.1, XM_013996597.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006506

Proteomic databases

PRIDEiF1RY56

Genome annotation databases

EnsembliENSSSCT00000006686; ENSSSCP00000006506; ENSSSCG00000006095
GeneIDi100512048
KEGGissc:100512048

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9134
VGNCiVGNC:86355, CCNE2

Phylogenomic databases

eggNOGiKOG0655, Eukaryota
GeneTreeiENSGT00940000156934
HOGENOMiCLU_020695_8_0_1
InParanoidiF1RY56
OMAiSWGCSKD
OrthoDBi993640at2759
TreeFamiTF101005

Enzyme and pathway databases

ReactomeiR-SSC-1538133, G0 and Early G1
R-SSC-187577, SCF(Skp2)-mediated degradation of p27/p21
R-SSC-2559586, DNA Damage/Telomere Stress Induced Senescence
R-SSC-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-SSC-69017, CDK-mediated phosphorylation and removal of Cdc6
R-SSC-69200, Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
R-SSC-69202, Cyclin E associated events during G1/S transition
R-SSC-69231, Cyclin D associated events in G1
R-SSC-69563, p53-Dependent G1 DNA Damage Response

Gene expression databases

BgeeiENSSSCG00000006095, Expressed in tonsil and 34 other tissues
ExpressionAtlasiF1RY56, baseline and differential

Family and domain databases

CDDicd00043, CYCLIN, 1 hit
InterProiView protein in InterPro
IPR039361, Cyclin
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR004367, Cyclin_C-dom
IPR028858, Cyclin_E
IPR006671, Cyclin_N
PANTHERiPTHR10177, PTHR10177, 1 hit
PTHR10177:SF70, PTHR10177:SF70, 1 hit
PfamiView protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit
PIRSFiPIRSF001771, Cyclin_A_B_D_E, 2 hits
SMARTiView protein in SMART
SM00385, CYCLIN, 1 hit
SM01332, Cyclin_C, 1 hit
SUPFAMiSSF47954, SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292, CYCLINS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1RY56_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1RY56
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: February 10, 2021
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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