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Entry version 89 (02 Jun 2021)
Sequence version 1 (03 May 2011)
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Protein
Submitted name:

Brevican

Gene

BCAN

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLectinARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
BrevicanImported
Submitted name:
Brevican core protein isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCANImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:85767, BCAN

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Extracellular matrixARBA annotation, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501457122623 – 906Sequence analysisAdd BLAST884

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi203 ↔ 224PROSITE-ProRule annotation
Disulfide bondi301 ↔ 322PROSITE-ProRule annotation
Disulfide bondi667 ↔ 676PROSITE-ProRule annotation
Disulfide bondi810 ↔ 853PROSITE-ProRule annotation
Disulfide bondi839 ↔ 866PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, Glycoprotein, ProteoglycanARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSSSCG00000006477, Expressed in frontal cortex and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000006902

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 155Ig-likeInterPro annotationAdd BLAST106
Domaini157 – 252LinkInterPro annotationAdd BLAST96
Domaini257 – 354LinkInterPro annotationAdd BLAST98
Domaini641 – 677EGF-likeInterPro annotationAdd BLAST37
Domaini690 – 804C-type lectinInterPro annotationAdd BLAST115
Domaini808 – 868SushiInterPro annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni439 – 635DisorderedSequence analysisAdd BLAST197
Regioni879 – 906DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi449 – 470Acidic residuesSequence analysisAdd BLAST22
Compositional biasi518 – 545Pro residuesSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the aggrecan/versican proteoglycan family.ARBA annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Immunoglobulin domainARBA annotation, RepeatARBA annotation, SignalSequence analysis, SushiPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4297, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157343

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000303_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1RP38

Identification of Orthologs from Complete Genome Data

More...
OMAi
APQISCV

Database of Orthologous Groups

More...
OrthoDBi
174823at2759

TreeFam database of animal gene trees

More...
TreeFami
TF332134

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033, CCP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.10.100.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR016187, CTDL_fold
IPR000742, EGF-like_dom
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003599, Ig_sub
IPR013106, Ig_V-set
IPR000538, Link_dom
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008, EGF, 1 hit
PF00059, Lectin_C, 1 hit
PF00084, Sushi, 1 hit
PF07686, V-set, 1 hit
PF00193, Xlink, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01265, LINKMODULE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032, CCP, 1 hit
SM00034, CLECT, 1 hit
SM00181, EGF, 1 hit
SM00409, IG, 1 hit
SM00406, IGv, 1 hit
SM00445, LINK, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 1 hit
SSF56436, SSF56436, 3 hits
SSF57535, SSF57535, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 1 hit
PS50835, IG_LIKE, 1 hit
PS00290, IG_MHC, 1 hit
PS01241, LINK_1, 1 hit
PS50963, LINK_2, 2 hits
PS50923, SUSHI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1RP38-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPLFLPLLA ALALAPVPAA LADALEGDSS EDRAFRVRIA GDAPLQGVLG
60 70 80 90 100
GALTIPCHVH YLRPPPSRRA ALGSPRVKWT FLSRGREAEV LVARGLRVKV
110 120 130 140 150
SEAYRFRVAL PGYPASLTDV SLVLSELRPN DSGIYRCEVQ HGIDDSSDAV
160 170 180 190 200
EVKVKGVVFL YREGSARYAF SFTGAQEACA RIGARIATPE QLYAAYLGGY
210 220 230 240 250
EQCDAGWLSD QTVRYPIQTP REACYGDMDG FPGVRNYGVV DPDDLYDVYC
260 270 280 290 300
YAEELNGELF LGAPPDKLTL EEARAYCQER GAEIATTGQL YAAWDGGLDR
310 320 330 340 350
CSPGWLADGS VRYPIVTPSQ RCGGGLPGVK TLFLFPNQTG FPNKHSRFNV
360 370 380 390 400
YCFRDSTQPS AIPEASNPAS DLASDALEAI VTVTETLEEL QLPQEAVESE
410 420 430 440 450
SRGAIYSIPI MEDGGGGSST PEDPAEAPRT LLEFETQSIV TPLGSSEEES
460 470 480 490 500
QVLEEEEKFE EEEEEEEVED KALWAWPSEP GSLHPEATLP TESAPEESLS
510 520 530 540 550
QASPPARAVL QPGASSPPYG EPEAPRPPRV LGPPTETPPT PREGNLASPP
560 570 580 590 600
SSTLVGARDI GVDTGGPELS GVPRGESEET GSSEDAPSML PATRAPEGTR
610 620 630 640 650
ELEIPSEEHS GRTVPAGTSV RAQPVLPTDS ASRGGVAVAP SSGDCVPSPC
660 670 680 690 700
HNGGTCLEEE EGVRCLCLPG YGGDLCDVGL RFCSPGWDSF QGACYKHFSK
710 720 730 740 750
RKSWEEAENK CRMYGAHLAS ISTPEEQDFI NNQYREYQWI GLNDRTIEGD
760 770 780 790 800
FLWSDGVPLL YENWNPGQPD SYFLSGENCV VMVWHDQGQW SDVPCNYHLS
810 820 830 840 850
YTCKMGLVSC GPPPELPLAQ VFGRPRLRYE VDTVLRYRCR EGLTQRNLPL
860 870 880 890 900
IRCQENGRWE TPQISCVPRR PARALHPVKA PEGRQRRLLG HWKTRSTPPP

NPASGP
Length:906
Mass (Da):98,508
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07623C4ED4448A1B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A287AHN9A0A287AHN9_PIG
Brevican
BCAN
666Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEMK02000022 Genomic DNA No translation available.
DQIR01144353 Transcribed RNA Translation: HDA99829.1

NCBI Reference Sequences

More...
RefSeqi
XP_003481480.1, XM_003481432.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00000007094; ENSSSCP00000006902; ENSSSCG00000006477

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100738802

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ssc:100738802

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000022 Genomic DNA No translation available.
DQIR01144353 Transcribed RNA Translation: HDA99829.1
RefSeqiXP_003481480.1, XM_003481432.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006902

Genome annotation databases

EnsembliENSSSCT00000007094; ENSSSCP00000006902; ENSSSCG00000006477
GeneIDi100738802
KEGGissc:100738802

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
63827
VGNCiVGNC:85767, BCAN

Phylogenomic databases

eggNOGiKOG4297, Eukaryota
GeneTreeiENSGT00940000157343
HOGENOMiCLU_000303_0_0_1
InParanoidiF1RP38
OMAiAPQISCV
OrthoDBi174823at2759
TreeFamiTF332134

Gene expression databases

BgeeiENSSSCG00000006477, Expressed in frontal cortex and 21 other tissues

Family and domain databases

CDDicd00033, CCP, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.100.10, 3 hits
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR016187, CTDL_fold
IPR000742, EGF-like_dom
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003599, Ig_sub
IPR013106, Ig_V-set
IPR000538, Link_dom
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008, EGF, 1 hit
PF00059, Lectin_C, 1 hit
PF00084, Sushi, 1 hit
PF07686, V-set, 1 hit
PF00193, Xlink, 2 hits
PRINTSiPR01265, LINKMODULE
SMARTiView protein in SMART
SM00032, CCP, 1 hit
SM00034, CLECT, 1 hit
SM00181, EGF, 1 hit
SM00409, IG, 1 hit
SM00406, IGv, 1 hit
SM00445, LINK, 2 hits
SUPFAMiSSF48726, SSF48726, 1 hit
SSF56436, SSF56436, 3 hits
SSF57535, SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 1 hit
PS50835, IG_LIKE, 1 hit
PS00290, IG_MHC, 1 hit
PS01241, LINK_1, 1 hit
PS50963, LINK_2, 2 hits
PS50923, SUSHI, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1RP38_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1RP38
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: June 2, 2021
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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