Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 79 (07 Oct 2020)
Sequence version 1 (03 May 2011)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

E3 ubiquitin-protein ligase MYCBP2

Gene

mycbp2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (By similarity). Plays a key role in neural development, probably by mediating ubiquitination of threonine residues on target proteins (By similarity). Involved in different processes such as regulation of neurite outgrowth, synaptic growth, synaptogenesis and axon degeneration (By similarity). Required in the visual system for correct fasciculation, targeting and mapping of retinal axons (PubMed:15590740). Acts as a regulator of pteridine synthesis (PubMed:15617681). May play a role in the regulation of the circadian clock gene expression (By similarity).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine.By similarity EC:2.3.2.33

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi4324Zinc 1By similarity1
Metal bindingi4327Zinc 1By similarity1
Metal bindingi4342Zinc 2By similarity1
Metal bindingi4344Zinc 2By similarity1
Metal bindingi4347Zinc 1By similarity1
Metal bindingi4350Zinc 1By similarity1
Metal bindingi4371Zinc 2By similarity1
Metal bindingi4374Zinc 2By similarity1
Metal bindingi4440Zinc 3By similarity1
Metal bindingi4443Zinc 3By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4454By similarity1
Metal bindingi4471Zinc 3By similarity1
Metal bindingi4474Zinc 3By similarity1
Metal bindingi4483Zinc 4By similarity1
Metal bindingi4486Zinc 4By similarity1
Metal bindingi4495Zinc 5By similarity1
Metal bindingi4498Zinc 5By similarity1
Metal bindingi4499Zinc 6By similarity1
Active sitei4506By similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei4507Important for catalysisBy similarity1
Sitei4512Important for catalysisBy similarity1
Metal bindingi4513Zinc 5By similarity1
Metal bindingi4516Zinc 5By similarity1
Sitei4520Important for catalysisBy similarity1
Metal bindingi4534Zinc 6By similarity1
Metal bindingi4548Zinc 6By similarity1
Metal bindingi4554Zinc 6By similarity1
Metal bindingi4565Zinc 4By similarity1
Metal bindingi4568Zinc 4By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri4324 – 4375RING-type; atypicalPROSITE-ProRule annotationAdd BLAST52

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor, Transferase
Biological processBiological rhythms, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase MYCBP2Curated (EC:2.3.2.33By similarity)
Alternative name(s):
Myc-binding protein 2Curated
Protein Esrom1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mycbp2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030616-132, mycbp2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Fishes display defects in the projection of retinal axons as well as reduced yellow pigmentation (PubMed:15590740, PubMed:15617681). Mutants show failure of anterior axons to map to the posterior tectum: in wild types, retinal axons from the anterior eye remain unbranched and are fasciculated until reaching the posterior tectum, while in mutants, anterior axons branch in the anterior tectum (PubMed:15590740). The posterior tectum is very sparsely innervated (PubMed:15590740). Defects are also detectable in the dorsoventral axis (PubMed:15590740). Reduced yellow pigmentation is caused by a deficiency of sepiapterin, a yellow pteridine (PubMed:15617681).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004446101 – 4574E3 ubiquitin-protein ligase MYCBP2Add BLAST4574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1733 ↔ 1850By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1RD40

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed when the visual system begins developing. In the eye, expressed in all cells, including retinal ganglion cells, with no obvious gradient.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000001220, Expressed in multi-cellular organism and 32 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000111741

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1RD40

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati591 – 646RCC1 1Sequence analysisAdd BLAST56
Repeati690 – 746RCC1 2Sequence analysisAdd BLAST57
Repeati943 – 993RCC1 3Sequence analysisAdd BLAST51
Repeati995 – 1051RCC1 4Sequence analysisAdd BLAST57
Repeati2336 – 2417FilaminPROSITE-ProRule annotationAdd BLAST82
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3617 – 3795DOCPROSITE-ProRule annotationAdd BLAST179

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni4435 – 4572Tandem cysteine domainBy similarityAdd BLAST138

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi175 – 179Poly-GluSequence analysis5
Compositional biasi757 – 805Cys-richPROSITE-ProRule annotationAdd BLAST49
Compositional biasi2630 – 2746Ser-richPROSITE-ProRule annotationAdd BLAST117
Compositional biasi3093 – 3113Lys-richPROSITE-ProRule annotationAdd BLAST21
Compositional biasi3506 – 3514Poly-GluSequence analysis9
Compositional biasi4201 – 4204Poly-GluSequence analysis4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners.By similarity
The tandem cysteine domain region confers threonine specificity and contains the two essential catalytic cysteine residues that relay ubiquitin. It binds four zinc ions in a C5HC7HC2 configuration.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RING-Cys relay (RCR) family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4324 – 4375RING-type; atypicalPROSITE-ProRule annotationAdd BLAST52

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1428, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155756

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000063_0_0_1

KEGG Orthology (KO)

More...
KOi
K10693

Identification of Orthologs from Complete Genome Data

More...
OMAi
EPSMLCH

Database of Orthologous Groups

More...
OrthoDBi
215263at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
F1RD40

TreeFam database of animal gene trees

More...
TreeFami
TF313151

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.30, 2 hits
2.60.120.260, 1 hit
2.60.120.820, 2 hits
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004939, APC_su10/DOC_dom
IPR017868, Filamin/ABP280_repeat-like
IPR008979, Galactose-bd-like_sf
IPR014756, Ig_E-set
IPR012983, PHR
IPR038648, PHR_sf
IPR009091, RCC1/BLIP-II
IPR000408, Reg_chr_condens
IPR003646, SH3-like_bac-type
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00630, Filamin, 1 hit
PF08005, PHR, 2 hits
PF00415, RCC1, 1 hit
PF08239, SH3_3, 1 hit
PF13639, zf-RING_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00633, RCCNDNSATION

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01337, APC10, 1 hit
SM00184, RING, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785, SSF49785, 1 hit
SSF50985, SSF50985, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51284, DOC, 1 hit
PS50194, FILAMIN_REPEAT, 1 hit
PS00626, RCC1_2, 2 hits
PS50012, RCC1_3, 2 hits
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: F1RD40-1) [UniParc]FASTAAdd to basket
Also known as: Variant 21 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMCAAAAAGA GGSGILSSSS HSMGLGVRVI PGAGNDFAPI GSGMGSCPVV
60 70 80 90 100
GARSDCRSRY QLLLSGRALA ERYRRIYTTA INDKEQGLNL GRGKKALSKK
110 120 130 140 150
KLKRRQKVKS KVKTRTKTDT LDGAFPVPDI KLHSNPSAFN VYCNVRHCVL
160 170 180 190 200
DWQQKEAALA LASRNSVQSG DSDSEEEEEY REPFVKLPKI IGIGLCGVFE
210 220 230 240 250
LIKETRFSHP SLCLRSLQAL LDMLQGQQPE SFQTEPPDVL ESLFHLLLET
260 270 280 290 300
TVRSTGMNDP TGQTLTALSC ACLFSLVVAW GDTGKTLQAV SAILTNNGSH
310 320 330 340 350
ACQTIQVPTI LNALQRSVQA VLVGKIQIQE WFGNGIKRAA LMNKWVLKEV
360 370 380 390 400
NIDDDEHCLL QTDGSFLYLL CKDGLYKVGS GYSGTVRGHV YNSTSRIRNR
410 420 430 440 450
KEKRSWLGFA QGCLLYRDMN SHNMAAIKIN PETLEQEGTI TVPGLQADGQ
460 470 480 490 500
NIIFTDGEYI NQIAACKDDG FVVRIYATSS DPALQQELQL KLARKCLHAC
510 520 530 540 550
GISLFDLEKD LHIISTGFDE EAALIGAGRE FALMKTASGK IYYTGKYQSL
560 570 580 590 600
GIKQGGPSSG KWVELPVTKS PKIVQFSVGH DGSHALLVAE DGSVFFTGSA
610 620 630 640 650
SKGEDGESTK SRRQPKPYKP KKMIKLETKM AVYTACNNGS SSIVTKDGEL
660 670 680 690 700
YMFGKDAIYS DSTCQVSDLK GHFVTQVAMG KAHTCVLTKS GEVWTFGVNN
710 720 730 740 750
KGQCGRDTGA MSQAGKAFGV ENMATAMDED LEDELDEKEE KSMMCQPGMH
760 770 780 790 800
KWKLDQCMVC TVCGDCTGYG ASCVSSGRPD RVPGGICGCG SGESGCSSCG
810 820 830 840 850
CCKACARELD GQEARQRGIF DAVKEMIPLD LLLGVNIEEH IQIRQEEKRQ
860 870 880 890 900
RINRRHRLEE GRGPLVFPGP LFMNQREQVL ARLRPLQAVK LMREKLKDGS
910 920 930 940 950
SERGDKDASK ITTYPPGAVR FDCELRAVQV SCGFHHSVVL MENGDVYTFG
960 970 980 990 1000
YGQHGQLGHG DVNSRGSPTL VQALPGPSTQ VTAGSNHTAV LLMDGQVFTF
1010 1020 1030 1040 1050
GSFSKGQLGR PILDMPYWNA KPSPMPNIGA KYGRKATWIG ASGDQTFLRI
1060 1070 1080 1090 1100
DEALINSHVL ATSEIFANKH IIGLVPTSIS EPPPFKCLLI NKLDGSCRTF
1110 1120 1130 1140 1150
NDSEQEDLQG FGLCLDPVYD VIWRFLPVTR EMCCYNAVIA DARVPTASDI
1160 1170 1180 1190 1200
QALCSILSPE LALPSGSHAS TTRSHGALHI LGCLDTLAAM QELKMGVASA
1210 1220 1230 1240 1250
EEETQAVMKV YSKEDYSVVN RFESHGGGWG YSAHSVEAIR FCADADILLG
1260 1270 1280 1290 1300
GLGLFGGRGE YTAKIKLFEL GPDGGDHETD GDLLAETDVL AYDCAAREKY
1310 1320 1330 1340 1350
AMMFDEPVLL QLGWWYVAWA RVSGPSSDCG SHGQATITTD DGVVFQFKSS
1360 1370 1380 1390 1400
KKSNNGTDVN AGQIPQLLYR LPSNDGNASK GKQQTSEPVH ILKRTFARTV
1410 1420 1430 1440 1450
SVDCFESLLS ILHWSWTTLV LGVEELRGLK GFQFTATLLD LERLRFVGTC
1460 1470 1480 1490 1500
CLRLLRVYIC DIFPISASTK AIVEESSKLA ECVGKTRSLL KKILSEGMDN
1510 1520 1530 1540 1550
CLTKLDNDPQ GYLSQPLTLL EAVLQECHNT FTACFHSFYP TPALQWACLC
1560 1570 1580 1590 1600
DLLNCLDQDI QEANFRTSSS RLLAAVMSAL CNTSVKLTSI LPIAYDGEVL
1610 1620 1630 1640 1650
LRSLVKQVST ENDSALAHRF PLLVAHMEKL SHTEENLMGM TTFREVLEKM
1660 1670 1680 1690 1700
LVIVVLPVRK SLRKEVELFS PHLVSNTCGL LASIVSELTA SALGSEVDGL
1710 1720 1730 1740 1750
NSLHSVKATP NRFTKTSQGR SWNTGNGSPD AICFTVDKPG VVLVGFCVYG
1760 1770 1780 1790 1800
GGGIHEYELE VLADDAQTEH PGDSAHSHRW TSLELVKGTY CTDDSPSDIA
1810 1820 1830 1840 1850
EIRLDKAVPL KENVKYAVRL RNYGSRTANG DGGITTVQCS DGVAFTFSTC
1860 1870 1880 1890 1900
SLSSNGTNQT RGQIPQILYY RSEYDGDLQS QLLSKANEED KNCSRALSVV
1910 1920 1930 1940 1950
SVVVRAAKDL LHRAFAVDVE DIPELLSSSS LFSMLLPLIL AYIGPVAASV
1960 1970 1980 1990 2000
PKAAVEVFGL VQELLPAVSA LNQKYAPPTF NPNQSTDSTT GNQPEQGLSA
2010 2020 2030 2040 2050
CTTSNHYAVL ESDHPYKQAG VTQYKVSFPD CVRWMTVEFD PQCGTAQPED
2060 2070 2080 2090 2100
VLRLLIPSRS LHFSGLSSKA LAHETINSWT ELKKFSGSSG WPTAVLVLPG
2110 2120 2130 2140 2150
NEALFSLETA SDYVKDEKAS FYGFKCVAVG YEFNPGLDEG IIQLEKELAY
2160 2170 2180 2190 2200
LGSVCAAALM KKDLALPIGN ELEEDLEILE EASLQVCKSH SGLLGKGLAL
2210 2220 2230 2240 2250
SHSPTILEAL EGNLPLHLQT NEHSFLEDFI TCVQSSSGGR LARWLQPDSY
2260 2270 2280 2290 2300
ADPQKTSLIL NKDDIRCGWP TTVVVQTKDQ YGDVVHVPNM KVEVKAVPVS
2310 2320 2330 2340 2350
QKKSIQQENM KKLQRLPGTS SNSATGTDLT FGGHPAPKLE ATYEPMIIKE
2360 2370 2380 2390 2400
ARYIAITMMK AYENYSFEEL RFASPTPKRP SENMLIRANT DGTYSANWTP
2410 2420 2430 2440 2450
GAVGLYTIHV TIDGIEIDAG LEVEVKDPPK GMIPPGTQMV KPKAEPQPSK
2460 2470 2480 2490 2500
VRKFVAKDSA GLRVRSHPSL QSEQIGIVQV NGTITFIDEI HNDDGVWLRL
2510 2520 2530 2540 2550
NDETVKKYVP NMNGYTEAWC LSFNQHLGRS LLVPVDVINS EGTWVQLDKN
2560 2570 2580 2590 2600
SVVEFCESDE GEAWSLARDR GGNQYLRHVE EQAVLEHGAQ TPPPSPFSVQ
2610 2620 2630 2640 2650
AFNRGMASSG AQGFDYGISN NKGDRDNMAS WSVSPGSKHR QESRSSKTDS
2660 2670 2680 2690 2700
HSNRSVDQVK SKNNESLSAS EALILKSDTG KLRSDSHSRS HSPNHNTLQA
2710 2720 2730 2740 2750
LKADGRTSGL RAESPNPGSR SSSPKQKTFT SGRSSPSSTS SPRSSSPHDK
2760 2770 2780 2790 2800
NLPAKVSPSK VHLDPPRERS KSDSYTLDPD TLRKKKVPLM EPLRGRSTSP
2810 2820 2830 2840 2850
KPKLPPKESK GGSSNAENRA PSPHVVQENL HSEVVEVCRS SALLSNDEGN
2860 2870 2880 2890 2900
DENSELHNAE EGSSKVHFSI GKAPVKEELE SRSSPKVSRK TSSRHVRPKK
2910 2920 2930 2940 2950
DKSGPLFKGE NVRPTEPAKQ AMSPSVAECA RAVFAAFLWH EGIVHDAMAC
2960 2970 2980 2990 3000
SSFLKFNPEL TKEHAPIRNS LSCQQGFDEK ESKLKNRHSL EISSALNMFN
3010 3020 3030 3040 3050
ISPHGPDISK MGSINKNKVL SMLKEPPLPE KCEDGKESVS YEMTSHSSMR
3060 3070 3080 3090 3100
SKSILPLTLQ HLVAFWEDIS MATIKAATQN MIFPSPGSSA ILKKKENEKD
3110 3120 3130 3140 3150
SKKTKKEKKK KEKAEVRPRG NLFGEMAQLA MGGPEKDTIC ELCGESHPYP
3160 3170 3180 3190 3200
VTYHMRQAHP GCGRYAGGQG YNSIGHFCGG WAGNCGDGGI GGSTWYLVCD
3210 3220 3230 3240 3250
RCREKYLREK QTAAREKVKQ SRKKPLQVKT PRALPTMEAH QVIRANALFL
3260 3270 3280 3290 3300
LSLSSAAEPS LLCHHPPKPF HSHLPSLKEG VSEELPNKMG CLYLQTLARQ
3310 3320 3330 3340 3350
HTENFGVYQD DNLFQDEMRY LRSTSVPAPY ISVTPDACPN VFEEPGSNMK
3360 3370 3380 3390 3400
SMPPSLETSP ITDSDTAKRT VFQRSYSVVA SEYDKQHSAS PARVKAVPRR
3410 3420 3430 3440 3450
RVHSGDAEVG SSLLRHPSPE LSRLISAHGS LSKGERNFQW PVLAFVIQHH
3460 3470 3480 3490 3500
DLEGLEVAMK HALRKSACRV FAMEAFNWLL CNVTQTTSLH DILWHFVASL
3510 3520 3530 3540 3550
TPSPFETEEE EDEENKGNKE NLEQEKDLGV CEHPLSDIII AGEAAHPLPH
3560 3570 3580 3590 3600
TFHCLLQTIS DLMMSLPSGS SLQQMALRCW SLKFKQSDHQ FLHQSNVFHH
3610 3620 3630 3640 3650
INNILSKSDD GDSEESFNIS VQSGYEAISQ ELCVVTCLKD LTSVVDIKTS
3660 3670 3680 3690 3700
SRPAMIGSLT DGSTETFWES GDEDKNKTKS ITISCVKGIN ASYVSVHVDN
3710 3720 3730 3740 3750
SRDIGNKVTS MIFLCGKAVE DLCRIKQIDL DSRHMGWVTS ELPGGDHHVI
3760 3770 3780 3790 3800
KIELKGPENT LRVRQVKVLG WKEGESIKIA GQISASVAQQ KNCEAETLRV
3810 3820 3830 3840 3850
FRLITSQVFG KLICGDAEPT PEQEEKNLLS SPEGEDKAPS DADLKEHMVG
3860 3870 3880 3890 3900
IIFSRSKLTN LQKQVCAHIV QAIRMEATRV REEWEHAISS KENANSQPSD
3910 3920 3930 3940 3950
DDASSDAYCF ELLSMVLALS GSNVGRQYLA QQLTLLQDLF SLLHTASPRV
3960 3970 3980 3990 4000
QRQVTSLLRR VLPEVTPMRL ASVIGVKALP PADISDIIHS TEKGDWTKLG
4010 4020 4030 4040 4050
ILDMFLGCIA KALTVQLKAK GTTIVGTAGM AAGKGVTTVT LPMIFNSSYI
4060 4070 4080 4090 4100
RRGESHWWMK GSTPPQIAEI IIKLVKDMAA GHLSDAWSRV TKNAIAETII
4110 4120 4130 4140 4150
ALTKMEEEHR SPVRCIATTR LWLALASLCV LDQDHVDRLS SGRWMGKDGQ
4160 4170 4180 4190 4200
QKQMPMCDNH DDGETAAIIL CNACGNLCTD CDRFLHLHRR TRTHQRQVFK
4210 4220 4230 4240 4250
EEEEAIKVDL HEGCGRTKLF WLMALADSKT MKAMVEFREH TGKPASSSSD
4260 4270 4280 4290 4300
ACRFCGTRHG TELSAVGSVC SDQDCQEYAK LACSKTHPCG HPCGGVKNED
4310 4320 4330 4340 4350
LCLPCLHGCD KTATCLKQDA DDMCMICFTE ALSAAPAIQL DCSHVFHLQC
4360 4370 4380 4390 4400
TRRVLENRWL GPRITFGFMS CPICKNKINH LVLKDLLDPI KELYEDVRRK
4410 4420 4430 4440 4450
ALMRLEYEGL HKSEAITMSG ARFFNNPAGF AMNRYAYYVC FKCKKAYFGG
4460 4470 4480 4490 4500
EARCDAEAGQ GDDYDPRELI CGACSDVSRA QMCSKHGTDF LEYKCRYCCS
4510 4520 4530 4540 4550
VAVFFCFGTT HFCNACHDDF QRMTSVPKEE LPHCPAGPKG KQLEGSECPL
4560 4570
HVVHPPTGEE FALGCGVCRN AHTF
Length:4,574
Mass (Da):501,847
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i17005A5FCAD05F74
GO
Isoform 2 (identifier: F1RD40-2) [UniParc]FASTAAdd to basket
Also known as: Variant 31 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     863-897: Missing.

Show »
Length:4,539
Mass (Da):497,790
Checksum:i565C26FF497E326A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8QJA3A0A2R8QJA3_DANRE
RCR-type E3 ubiquitin transferase
mycbp2
4,543Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD58756 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAD61237 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1834I → M in AAW31810 (PubMed:15590740).Curated1
Sequence conflicti2427D → A in AAW31810 (PubMed:15590740).Curated1
Sequence conflicti3515N → T in AAW31810 (PubMed:15590740).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059624863 – 897Missing in isoform 2. Add BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY818192 mRNA Translation: AAW31810.1
AL731656 Genomic DNA Translation: CAD61237.2 Sequence problems.
AL731859 Genomic DNA Translation: CAD58756.1 Sequence problems.
AL840634 Genomic DNA No translation available.
BX510646 Genomic DNA No translation available.
CR628366 Genomic DNA No translation available.
CU138551 Genomic DNA No translation available.
GU299766 mRNA Translation: ADB77874.1
GU299767 mRNA Translation: ADB77875.1

NCBI Reference Sequences

More...
RefSeqi
NP_001012247.2, NM_001012247.2 [F1RD40-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000039157; ENSDARP00000028785; ENSDARG00000001220 [F1RD40-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
368439

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:368439

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY818192 mRNA Translation: AAW31810.1
AL731656 Genomic DNA Translation: CAD61237.2 Sequence problems.
AL731859 Genomic DNA Translation: CAD58756.1 Sequence problems.
AL840634 Genomic DNA No translation available.
BX510646 Genomic DNA No translation available.
CR628366 Genomic DNA No translation available.
CU138551 Genomic DNA No translation available.
GU299766 mRNA Translation: ADB77874.1
GU299767 mRNA Translation: ADB77875.1
RefSeqiNP_001012247.2, NM_001012247.2 [F1RD40-1]

3D structure databases

SMRiF1RD40
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000111741

Proteomic databases

PaxDbiF1RD40

Genome annotation databases

EnsembliENSDART00000039157; ENSDARP00000028785; ENSDARG00000001220 [F1RD40-1]
GeneIDi368439
KEGGidre:368439

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23077
ZFINiZDB-GENE-030616-132, mycbp2

Phylogenomic databases

eggNOGiKOG1428, Eukaryota
GeneTreeiENSGT00940000155756
HOGENOMiCLU_000063_0_0_1
KOiK10693
OMAiEPSMLCH
OrthoDBi215263at2759
PhylomeDBiF1RD40
TreeFamiTF313151

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

Protein Ontology

More...
PROi
PR:F1RD40

Gene expression databases

BgeeiENSDARG00000001220, Expressed in multi-cellular organism and 32 other tissues

Family and domain databases

Gene3Di2.130.10.30, 2 hits
2.60.120.260, 1 hit
2.60.120.820, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004939, APC_su10/DOC_dom
IPR017868, Filamin/ABP280_repeat-like
IPR008979, Galactose-bd-like_sf
IPR014756, Ig_E-set
IPR012983, PHR
IPR038648, PHR_sf
IPR009091, RCC1/BLIP-II
IPR000408, Reg_chr_condens
IPR003646, SH3-like_bac-type
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00630, Filamin, 1 hit
PF08005, PHR, 2 hits
PF00415, RCC1, 1 hit
PF08239, SH3_3, 1 hit
PF13639, zf-RING_2, 1 hit
PRINTSiPR00633, RCCNDNSATION
SMARTiView protein in SMART
SM01337, APC10, 1 hit
SM00184, RING, 1 hit
SUPFAMiSSF49785, SSF49785, 1 hit
SSF50985, SSF50985, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS51284, DOC, 1 hit
PS50194, FILAMIN_REPEAT, 1 hit
PS00626, RCC1_2, 2 hits
PS50012, RCC1_3, 2 hits
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYCB2_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1RD40
Secondary accession number(s): D3JU51
, D3JU52, F1QI76, Q5IBM5, Q7ZZ57, Q8AW10
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2018
Last sequence update: May 3, 2011
Last modified: October 7, 2020
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again