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Protein
Submitted name:

Glucagon receptor b

Gene

gcgrb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • gastric inhibitory peptide receptor activity Source: InterPro
  • peptide hormone binding Source: ZFIN

GO - Biological processi

  • cell surface receptor signaling pathway Source: InterPro
  • regulation of glucose metabolic process Source: ZFIN

Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-DRE-163359 Glucagon signaling in metabolic regulation
R-DRE-416476 G alpha (q) signalling events
R-DRE-418555 G alpha (s) signalling events
R-DRE-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Submitted name:
Glucagon receptor bImported
Gene namesi
Name:gcgrbImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 1

Organism-specific databases

ZFINiZDB-GENE-050516-2 gcgrb

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei129 – 150HelicalSequence analysisAdd BLAST22
Transmembranei251 – 270HelicalSequence analysisAdd BLAST20
Transmembranei290 – 313HelicalSequence analysisAdd BLAST24
Transmembranei334 – 356HelicalSequence analysisAdd BLAST23
Transmembranei368 – 392HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500326916122 – 509Sequence analysisAdd BLAST488

Proteomic databases

PaxDbiF1RCQ6

Expressioni

Gene expression databases

BgeeiENSDARG00000036272

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000013211

Structurei

3D structure databases

ProteinModelPortaliF1RCQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 114G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST78
Domaini127 – 393G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST267

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
InParanoidiF1RCQ6
KOiK04583
OMAiNTSECED
OrthoDBiEOG091G0NF8
TreeFamiTF315710

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR001749 GPCR_2_GIP_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01129 GIPRECEPTOR
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

F1RCQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVCLLLVLF ILTTHTQVSS GKSLKLLQEQ WRIYTNECIQ SFISTPPAAG
60 70 80 90 100
LVCNRTFDQY VCWPDGLPGT TVNVSCPWYL PWYSKVDHGL VYRVCGADGR
110 120 130 140 150
WVHGKNTSEC EQDDPGQKQY GQILSKFRAM YTVGYSLSLA ALTLALGILV
160 170 180 190 200
SFRKLHCMRN NIHMNLFGSF MVRALSILIK DTLLDQMNRA RSGPSHYQST
210 220 230 240 250
RWLDTQTVVG CRSAMVMMQY SVMANNCWLL VEGLYLHSLL VTTVFSERNY
260 270 280 290 300
FCIYLCIGWG APLIFVLPWM TVKYLYENEE CWERNMNMGY WWIIRSPILF
310 320 330 340 350
AYLINFIIFI RIIKILMSKL KAHQMRYTDY KFRLAKSTLT LIPLLGIHAV
360 370 380 390 400
LFTFVIDESV PKESLLRLIR LFYDLLFSSF QGLLVAILYC FVNKEVQSEM
410 420 430 440 450
LKKWKRWKLG KDIDEEYRHT HSQTPHAKSS TAPPAAHDCP DTSSSLESQR
460 470 480 490 500
LVTGLQNGLS RSRGRARLQF TSQTQEGASN CSSLTEDICL EERPLNNEGS

AAVLEETNV
Length:509
Mass (Da):58,358
Last modified:June 26, 2013 - v2
Checksum:iD5EAF4716D9AAA9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928676 Genomic DNA No translation available.
RefSeqiXP_009293538.1, XM_009295263.2

Genome annotation databases

EnsembliENSDART00000021878; ENSDARP00000013211; ENSDARG00000036272
GeneIDi565237
KEGGidre:565237

Similar proteinsi

Entry informationi

Entry nameiF1RCQ6_DANRE
AccessioniPrimary (citable) accession number: F1RCQ6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 26, 2013
Last modified: April 25, 2018
This is version 52 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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