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UniProtKB - F1RCN2 (F1RCN2_DANRE)

Entry version 62 (16 Oct 2019)
Sequence version 1 (03 May 2011)
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Protein
Submitted name:

CECR2 histone acetyl-lysine reader

Gene

cecr2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CECR2 histone acetyl-lysine readerImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cecr2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 25

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-131121-533 cecr2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		F1RCN2

PRoteomics IDEntifications database

More...PRIDEi		F1RCN2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000078310 Expressed in 23 organ(s), highest expression level in testis

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000100992

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini416 – 486BromoInterPro annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni172 – 196DisorderedSequence analysisAdd BLAST25
Regioni287 – 321DisorderedSequence analysisAdd BLAST35
Regioni505 – 610DisorderedSequence analysisAdd BLAST106
Regioni665 – 695DisorderedSequence analysisAdd BLAST31
Regioni760 – 820DisorderedSequence analysisAdd BLAST61
Regioni846 – 946DisorderedSequence analysisAdd BLAST101
Regioni1054 – 1228DisorderedSequence analysisAdd BLAST175
Regioni1247 – 1432DisorderedSequence analysisAdd BLAST186

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili199 – 226Sequence analysisAdd BLAST28
Coiled coili327 – 364Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi178 – 196PolyampholyteSequence analysisAdd BLAST19
Compositional biasi288 – 307PolarSequence analysisAdd BLAST20
Compositional biasi505 – 534PolyampholyteSequence analysisAdd BLAST30
Compositional biasi535 – 566PolarSequence analysisAdd BLAST32
Compositional biasi567 – 581Pro-richSequence analysisAdd BLAST15
Compositional biasi669 – 683PolarSequence analysisAdd BLAST15
Compositional biasi760 – 815PolarSequence analysisAdd BLAST56
Compositional biasi846 – 873PolarSequence analysisAdd BLAST28
Compositional biasi881 – 940PolarSequence analysisAdd BLAST60
Compositional biasi1065 – 1092PolarSequence analysisAdd BLAST28
Compositional biasi1115 – 1148PolarSequence analysisAdd BLAST34
Compositional biasi1158 – 1185PolarSequence analysisAdd BLAST28
Compositional biasi1198 – 1228PolarSequence analysisAdd BLAST31
Compositional biasi1247 – 1269PolarSequence analysisAdd BLAST23
Compositional biasi1287 – 1344PolarSequence analysisAdd BLAST58
Compositional biasi1345 – 1375PolyampholyteSequence analysisAdd BLAST31

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

BromodomainPROSITE-ProRule annotationSAAS annotation, Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1472 Eukaryota
COG5076 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160360

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		F1RCN2

Identification of Orthologs from Complete Genome Data

More...OMAi		ESEYTIM

Database of Orthologous Groups

More...OrthoDBi		103411at2759

TreeFam database of animal gene trees

More...TreeFami		TF324727

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.920.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR029614 CECR2

The PANTHER Classification System

More...PANTHERi		PTHR47092 PTHR47092, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00439 Bromodomain, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00297 BROMO, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47370 SSF47370, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1RCN2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQGCITSAE EIQSWWEVPA IAHFCSLFRT AFNLPDFEIE ELEQALLKQD 
        60         70         80         90        100
QDFLSVLLCS LLKGCYQRSD ITIQSFSGYL EDIINYRWEL EEGKPNPLKE 
       110        120        130        140        150
HPFEELPTRT QVELLHRLCD YRLDAADVFD RLKGLDSDSL RVEPLGQDGN 
       160        170        180        190        200
GALYWYFYGT RLYKEEPVEV VSPQYSNDKA SEKKRRGRPP KNKPEDIDLS 
       210        220        230        240        250
VVEEGVNSVK EEYERVEETK PAIERERGAW SVICETEEQW LNLAESIKDK 
       260        270        280        290        300
ISPQDRHLHR IITQNFLPEI SNMIEHKEKE LKQKLLNSPK EHNSQSEQHS 
       310        320        330        340        350
SKDNWQMQAT TEEERQRDED LERQVLLAEQ RKEDERLLQE EREREEQERV 
       360        370        380        390        400
KAVEERARRR KQREEKAWLL SQGKELPPEL LNLETHSPIR RARRTKQFYE 
       410        420        430        440        450
IDDDYTALYK VLEALKAHKD AWPFMEPVDE SYAPNYHEII QTPMDLSTIE 
       460        470        480        490        500
RKLNDGEYLA KDEFVADVKL MFGNCLEYNG EESEYTIMAE SLERCFTRAL 
       510        520        530        540        550
LKHFPSEDGD TDEEFHVSSE DRKDKKKNKN HKQSGPESLI RATEQVQKRK 
       560        570        580        590        600
TSNSGKGNNQ QQEKPKSTLQ PPPPHYSNGP PHPHNIHPGQ QQRGMLHPAQ 
       610        620        630        640        650
QFQRPSGPGM YAQHMMIDAQ YPYPGQRPLI SRPPGDHENQ HVPHFNMQGS 
       660        670        680        690        700
HINGPHLGTR YTVGPDGQPL QPPHQQHSYS GPTHGPSLGP RPMALQPGGL 
       710        720        730        740        750
CSPPPEGNMY PSHQHPEGQS MRPMGNAYTR PGVPMHSSYP PYGPHGMNIP 
       760        770        780        790        800
RMWPPMNHQR QPTPSGNMMQ EPSASGQHPY NHNMIHSQNS TGFTMANGQF 
       810        820        830        840        850
KMPSANSQGP VGQKLQGGPQ ASRLHLASML DSPEMIALQQ LSASSSHHVG 
       860        870        880        890        900
NFQSPQQSGG NPLASAEQSS PEKQLHMPSR DKQHTPVSSK GSSPKSGNKM 
       910        920        930        940        950
STGEISLTEA ESRSYPSTTE KSEQPSQVTG LASVSSPSKE LNQNEDKHRL 
       960        970        980        990       1000
SNLEKIHDQL NSQLGPPNLK SVDGFSFPLN SPQPMPHKTQ DDIPLNISQQ 
      1010       1020       1030       1040       1050
INKHALPQII QNGSQRQSQN VPPQILQNIP QQMTENVIHQ YHQSVSQQIQ 
      1060       1070       1080       1090       1100
NNESVRGPQV GPLHGMPQIS SQGGQPGVHQ PATLSSLPPS HPVSHPLAQP 
      1110       1120       1130       1140       1150
SPADQGDQRP CEPTSRKVSD GSTASQDGSN ANLRTDCTSG QYKQQPFSPE 
      1160       1170       1180       1190       1200
SKPPLVRQEQ APLQNQTPPT HSQGPESNNV THYGISEPAH QPFGPHHGRP 
      1210       1220       1230       1240       1250
LQTSNHQSYT SQGLPSHENN PNQNPAHYPA FHQQSIQYQY RMATQHSQGH 
      1260       1270       1280       1290       1300
PSMHPQFQQQ QQFYQQQRHG RPVFPTEEWP RHPYQPQHPV MSNSYPTPSA 
      1310       1320       1330       1340       1350
GSFNGRHNDN GMSPHGSDGS VGSLMSPNLL PDGSHSSSFE NKEDGSPAKQ 
      1360       1370       1380       1390       1400
ARTEEPSERS ESPKEILDLD SHNATARHHT SAQPHSSFPY GPRGMHPSMQ 
      1410       1420       1430       1440       1450
QSAAPPPHMM ASGPYSSQQF SGGHFAPQNP HPHLMEALQR PQHLPFSPGQ 
      1460       1470       1480       1490       1500
SRMTMYRHPN VAGHFQGMMV PQRAVVAEHL FRSGHQMLRT ASPNGQGHKQ 

GV
Length:1,502
Mass (Da):169,130
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDCC5F4445568D020
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX004976 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_005174419.1, XM_005174362.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000110426; ENSDARP00000100992; ENSDARG00000078310

Database of genes from NCBI RefSeq genomes

More...GeneIDi		799918

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX004976 Genomic DNA No translation available.
RefSeqiXP_005174419.1, XM_005174362.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000100992

Proteomic databases

PaxDbiF1RCN2
PRIDEiF1RCN2

Genome annotation databases

EnsembliENSDART00000110426; ENSDARP00000100992; ENSDARG00000078310
GeneIDi799918

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27443
ZFINiZDB-GENE-131121-533 cecr2

Phylogenomic databases

eggNOGiKOG1472 Eukaryota
COG5076 LUCA
GeneTreeiENSGT00940000160360
InParanoidiF1RCN2
OMAiESEYTIM
OrthoDBi103411at2759
TreeFamiTF324727

Gene expression databases

BgeeiENSDARG00000078310 Expressed in 23 organ(s), highest expression level in testis

Family and domain databases

Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR029614 CECR2
PANTHERiPTHR47092 PTHR47092, 2 hits
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1RCN2_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1RCN2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: October 16, 2019
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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