UniProtKB - F1RBC8 (ABCD1_DANRE)
ATP-binding cassette sub-family D member 1
abcd1
Functioni
ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Coupled to the ATP-dependent transporter activity has also a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (By similarity).
Involved in oligodendrocyte patterning and myelination (PubMed:28911205).
By similarity1 PublicationCatalytic activityi
- a very long-chain fatty acid(in) + ATP + H2O = a very long-chain fatty acid(out) + ADP + H+ + phosphateBy similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 515 – 522 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ABC-type fatty-acyl-CoA transporter activity Source: UniProtKB-EC
- acyl-CoA hydrolase activity Source: UniProtKB
- ATPase-coupled transmembrane transporter activity Source: GO_Central
- ATP binding Source: GO_Central
- long-chain fatty acid transporter activity Source: UniProtKB
GO - Biological processi
- adrenal gland development Source: UniProtKB
- cholesterol transport Source: ZFIN
- fatty acid beta-oxidation Source: UniProtKB
- long-chain fatty acid import into peroxisome Source: UniProtKB
- motor behavior Source: UniProtKB
- oligodendrocyte development Source: UniProtKB
- peroxisome organization Source: GO_Central
- positive regulation of myelination Source: UniProtKB
- swimming behavior Source: UniProtKB
- very long-chain fatty acid catabolic process Source: GO_Central
- very long-chain fatty acid metabolic process Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Translocase |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-DRE-1369062, ABC transporters in lipid homeostasis R-DRE-2046105, Linoleic acid (LA) metabolism R-DRE-2046106, alpha-linolenic acid (ALA) metabolism R-DRE-390247, Beta-oxidation of very long chain fatty acids R-DRE-9603798, Class I peroxisomal membrane protein import |
Protein family/group databases
TCDBi | 3.A.1.203.15, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:abcd1Imported ORF Names:si:ch211-169p10 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-050517-27, abcd1 |
Subcellular locationi
Peroxisome
- Peroxisome membrane By similarity; Multi-pass membrane protein Sequence analysis
Peroxisome
- peroxisomal membrane Source: GO_Central
- peroxisome Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 98 – 118 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 138 – 158 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 245 – 265 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 340 – 360 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 481 – 501 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, PeroxisomePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000445227 | 1 – 766 | ATP-binding cassette sub-family D member 1Add BLAST | 766 |
Proteomic databases
PaxDbi | F1RBC8 |
Expressioni
Developmental stagei
Gene expression databases
Bgeei | ENSDARG00000074876, Expressed in mature ovarian follicle and 24 other tissues |
ExpressionAtlasi | F1RBC8, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 101 – 393 | ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST | 293 | |
Domaini | 482 – 708 | ABC transporterPROSITE-ProRule annotationAdd BLAST | 227 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 728 – 766 | DisorderedSequence analysisAdd BLAST | 39 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 735 – 750 | Acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 751 – 766 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0064, Eukaryota |
GeneTreei | ENSGT00950000182955 |
HOGENOMi | CLU_007587_1_1_1 |
InParanoidi | F1RBC8 |
OrthoDBi | 309052at2759 |
PhylomeDBi | F1RBC8 |
TreeFami | TF105205 |
Family and domain databases
Gene3Di | 1.20.1560.10, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR031237, ALDP IPR027417, P-loop_NTPase |
PANTHERi | PTHR11384:SF21, PTHR11384:SF21, 1 hit |
Pfami | View protein in Pfam PF06472, ABC_membrane_2, 1 hit PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF90123, SSF90123, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 1 hit PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MSVYSKLPSQ LKKPLVKKAV VLLIALYGVK KLSPYFFGKL KGRTSKQVKG
60 70 80 90 100
ADPLTSNGEP LVEAARKRKR SPAVNREFFD RLIRLLKILF PRLFCKELGL
110 120 130 140 150
LGFHSLALIS RTFLSIYVAN LDGQIVKTIV KKDPRAFVVE LTKWLLIAIP
160 170 180 190 200
ATFVNSAIRY LEGQLTLAFR TRLVTHAYML YFSDQTYYRV SNMDGRLANP
210 220 230 240 250
DQSLTEDVVM FAASVAHLYS NLTKPILDVV VTCYTLIKTA ESKGANTTWP
260 270 280 290 300
SVIAGIVVAL TAKVLRAFSP RFGKLVAEEA RRKGDLRYMH SRIIANSEEI
310 320 330 340 350
AFYGGHKIEM LQLQRSYNSL SRQINLILFK RLWYVMLEQF LMKYLWSASG
360 370 380 390 400
LVMVAVPIIT ATGYSKYDSE DVKQAALDMK EEDLVSERTQ AFTTARSLLN
410 420 430 440 450
AAADAVERIM VSYKEVTELA GYTARVYEMF EVFEDVRDGV YRRSATEVKP
460 470 480 490 500
EETGAPQNVT HGMRVEGPLQ IRGQVIDVEQ GIKCENLPII TPTGDVVVSS
510 520 530 540 550
LNMQVDEGMH LLITGPNGCG KSSLFRILSG LWPVYSGVLY KPSPDHMFYI
560 570 580 590 600
PQRPYMSVGT LRDQVIYPHS VQEMQEKGIT DRQLEEILQT VSLRYILERE
610 620 630 640 650
GGWDAVSDWK DVLSGGEKQR MGMARMFYHK PQYALLDECT SAVSIDVEGK
660 670 680 690 700
IFEAAKDAGI SLLSITHRPS LWKYHSHLLQ FDGEGGWRFE KLDASTRISL
710 720 730 740 750
QDEKIRLETQ LSGIPKMQQR LTELCRILGE DSSLPTPGDE EEDEEEDEKQ
760
TERDVQSAGK EKDLME
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA9JRC4 | A9JRC4_DANRE | ATP-binding cassette sub-family D m... | abcd1 zgc:172102 | 640 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX005406 Genomic DNA No translation available. |
RefSeqi | XP_005166771.1, XM_005166714.3 |
Genome annotation databases
Ensembli | ENSDART00000111392; ENSDARP00000101144; ENSDARG00000074876 |
GeneIDi | 566367 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX005406 Genomic DNA No translation available. |
RefSeqi | XP_005166771.1, XM_005166714.3 |
3D structure databases
AlphaFoldDBi | F1RBC8 |
SMRi | F1RBC8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000101144 |
Protein family/group databases
TCDBi | 3.A.1.203.15, the atp-binding cassette (abc) superfamily |
Proteomic databases
PaxDbi | F1RBC8 |
Genome annotation databases
Ensembli | ENSDART00000111392; ENSDARP00000101144; ENSDARG00000074876 |
GeneIDi | 566367 |
Organism-specific databases
CTDi | 215 |
ZFINi | ZDB-GENE-050517-27, abcd1 |
Phylogenomic databases
eggNOGi | KOG0064, Eukaryota |
GeneTreei | ENSGT00950000182955 |
HOGENOMi | CLU_007587_1_1_1 |
InParanoidi | F1RBC8 |
OrthoDBi | 309052at2759 |
PhylomeDBi | F1RBC8 |
TreeFami | TF105205 |
Enzyme and pathway databases
Reactomei | R-DRE-1369062, ABC transporters in lipid homeostasis R-DRE-2046105, Linoleic acid (LA) metabolism R-DRE-2046106, alpha-linolenic acid (ALA) metabolism R-DRE-390247, Beta-oxidation of very long chain fatty acids R-DRE-9603798, Class I peroxisomal membrane protein import |
Miscellaneous databases
PROi | PR:F1RBC8 |
Gene expression databases
Bgeei | ENSDARG00000074876, Expressed in mature ovarian follicle and 24 other tissues |
ExpressionAtlasi | F1RBC8, baseline |
Family and domain databases
Gene3Di | 1.20.1560.10, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR031237, ALDP IPR027417, P-loop_NTPase |
PANTHERi | PTHR11384:SF21, PTHR11384:SF21, 1 hit |
Pfami | View protein in Pfam PF06472, ABC_membrane_2, 1 hit PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF90123, SSF90123, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 1 hit PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ABCD1_DANRE | |
Accessioni | F1RBC8Primary (citable) accession number: F1RBC8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2018 |
Last sequence update: | May 3, 2011 | |
Last modified: | May 25, 2022 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families