UniProtKB - F1RAP6 (F1RAP6_DANRE)
Protein
Submitted name:
Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium-derived factor), member 2b
Gene
serpinf2b
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- serine-type endopeptidase inhibitor activity Source: GO_Central
GO - Biological processi
- negative regulation of endopeptidase activity Source: GO_Central
- negative regulation of fibrinolysis Source: InterPro
Enzyme and pathway databases
Reactomei | R-DRE-114608, Platelet degranulation R-DRE-75205, Dissolution of Fibrin Clot |
Names & Taxonomyi
Protein namesi | Submitted name: Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium-derived factor), member 2bImported |
Gene namesi | Name:serpinf2bImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-061215-114, serpinf2b |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_5009954162 | 20 – 480 | Sequence analysisAdd BLAST | 461 |
Proteomic databases
PaxDbi | F1RAP6 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000061383, Expressed in liver and 18 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 114 – 453 | SERPINInterPro annotationAdd BLAST | 340 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 60 – 90 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 457 – 480 | DisorderedSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Belongs to the serpin family.UniRule annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000158386 |
HOGENOMi | CLU_023330_3_2_1 |
OMAi | FKLEYSQ |
TreeFami | TF317350 |
Family and domain databases
CDDi | cd02053, serpinF2_A2AP, 1 hit |
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR033833, Alpha2AP_serpin_dom IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F1RAP6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNLCFLAFLL LCYSKQGWTD DVTDPEDGVD PVIPLIPLTP SKPISDLKAT
60 70 80 90 100
LDPTVTEELT VNPDGLEADP PTPGPSSGQK EGSSEEELDT LCDGDMTGKQ
110 120 130 140 150
IKRTIGNGIM KLGLLFLENL KPSPDQPNVI FSPLSLSVAL SQLALGATND
160 170 180 190 200
TEELLLHHLH ADALPCYHTA LSSLLRNFRK RSMPIASRIY LKTGFKAKSD
210 220 230 240 250
FMEDSQKLYD SEPATLTDVN DVNEWVKKVT NGHISEFLSS LPPSAVMMLI
260 270 280 290 300
NAMHYKGEWL TRFDPHFTST ENFYIDENQI VNVDMMLGPK YPLSVFTHHE
310 320 330 340 350
LDAQVARFPF KGDRSLLVVM PTSGHVNVSA IAAKLNISDL YSRLPRERNM
360 370 380 390 400
QVKLPKFKLD FNQDLQEAMT SMGLGKLFSH PKLDRITEVP LFVSSVQHMS
410 420 430 440 450
SVEINEEGAE AVAATSVVIS RSNPSFTVNQ PFFFALMDDL SQTPLFLGVI
460 470 480
SNPNPGASTM ITNPGNADKT DDKPFEVHPK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketR4GET4 | R4GET4_DANRE | Serpin peptidase inhibitor, clade F... | serpinf2b | 112 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU861670 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000150152; ENSDARP00000124022; ENSDARG00000061383 ENSDART00000186432; ENSDARP00000148606; ENSDARG00000061383 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU861670 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000124022 |
Proteomic databases
PaxDbi | F1RAP6 |
Genome annotation databases
Ensembli | ENSDART00000150152; ENSDARP00000124022; ENSDARG00000061383 ENSDART00000186432; ENSDARP00000148606; ENSDARG00000061383 |
Organism-specific databases
ZFINi | ZDB-GENE-061215-114, serpinf2b |
Phylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000158386 |
HOGENOMi | CLU_023330_3_2_1 |
OMAi | FKLEYSQ |
TreeFami | TF317350 |
Enzyme and pathway databases
Reactomei | R-DRE-114608, Platelet degranulation R-DRE-75205, Dissolution of Fibrin Clot |
Gene expression databases
Bgeei | ENSDARG00000061383, Expressed in liver and 18 other tissues |
Family and domain databases
CDDi | cd02053, serpinF2_A2AP, 1 hit |
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR033833, Alpha2AP_serpin_dom IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1RAP6_DANRE | |
Accessioni | F1RAP6Primary (citable) accession number: F1RAP6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | May 3, 2011 | |
Last modified: | April 7, 2021 | |
This is version 73 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |