UniProtKB - F1RAE2 (F1RAE2_DANRE)
Protein
H/ACA ribonucleoprotein complex subunit
Gene
gar1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.UniRule annotation
GO - Molecular functioni
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- pseudouridine synthesis Source: InterPro
- rRNA processing Source: UniProtKB-KW
Keywordsi
Molecular function | RibonucleoproteinUniRule annotation, RNA-bindingUniRule annotation |
Biological process | Ribosome biogenesisUniRule annotationARBA annotation, rRNA processingUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: H/ACA ribonucleoprotein complex subunitUniRule annotation |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-040426-893, gar1 |
Subcellular locationi
Keywords - Cellular componenti
NucleusUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000076526, Expressed in somite and 34 other tissues |
Interactioni
Subunit structurei
Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
UniRule annotationFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 30 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 150 – 225 | DisorderedSequence analysisAdd BLAST | 76 |
Sequence similaritiesi
Belongs to the GAR1 family.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00730000111223 |
HOGENOMi | CLU_080002_0_1_1 |
OMAi | FNRQQDY |
OrthoDBi | 1530008at2759 |
TreeFami | TF350747 |
Family and domain databases
Gene3Di | 2.40.10.230, 1 hit |
InterProi | View protein in InterPro IPR038664, Gar1/Naf1_Cbf5-bd_sf IPR007504, H/ACA_rnp_Gar1/Naf1 IPR009000, Transl_B-barrel_sf |
Pfami | View protein in Pfam PF04410, Gar1, 1 hit |
SUPFAMi | SSF50447, SSF50447, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
F1RAE2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFRGGGGGR GGGFNRGGGG GRGGGFGGGR GGGFGGGRGG GFGGGRGGRG
60 70 80 90 100
GFNRNQDYGP PEYVVALGEF MHPCEDEIVC KCVTEENKVP YFNAPVYLEN
110 120 130 140 150
KEQIGKVDEI FGQLRDFYFS VKLSDNMKAS SFKKLQKFYI DPMKLLPLQR
160 170 180 190 200
FLPRPPGEKG PPRGGRGGGG RGGRGGGFRG GRGANGGGRG GFGGRGGGFG
210 220
GRGGGGGGFR GGRGGGGGRG FRGGR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ7ZVE0 | GAR1_DANRE | H/ACA ribonucleoprotein complex sub... | gar1 nola1, zgc:56086 | 226 | Annotation score: | ||
E7EXU2 | E7EXU2_DANRE | H/ACA ribonucleoprotein complex sub... | gar1 | 230 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU467639 Genomic DNA No translation available. |
RefSeqi | NP_957269.2, NM_200975.2 |
Genome annotation databases
Ensembli | ENSDART00000111189; ENSDARP00000101401; ENSDARG00000076526 |
GeneIDi | 393950 |
KEGGi | dre:393950 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU467639 Genomic DNA No translation available. |
RefSeqi | NP_957269.2, NM_200975.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSDART00000111189; ENSDARP00000101401; ENSDARG00000076526 |
GeneIDi | 393950 |
KEGGi | dre:393950 |
Organism-specific databases
CTDi | 54433 |
ZFINi | ZDB-GENE-040426-893, gar1 |
Phylogenomic databases
GeneTreei | ENSGT00730000111223 |
HOGENOMi | CLU_080002_0_1_1 |
OMAi | FNRQQDY |
OrthoDBi | 1530008at2759 |
TreeFami | TF350747 |
Gene expression databases
Bgeei | ENSDARG00000076526, Expressed in somite and 34 other tissues |
Family and domain databases
Gene3Di | 2.40.10.230, 1 hit |
InterProi | View protein in InterPro IPR038664, Gar1/Naf1_Cbf5-bd_sf IPR007504, H/ACA_rnp_Gar1/Naf1 IPR009000, Transl_B-barrel_sf |
Pfami | View protein in Pfam PF04410, Gar1, 1 hit |
SUPFAMi | SSF50447, SSF50447, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1RAE2_DANRE | |
Accessioni | F1RAE2Primary (citable) accession number: F1RAE2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | May 3, 2011 | |
Last modified: | December 2, 2020 | |
This is version 65 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |