UniProtKB - F1RA48 (F1RA48_DANRE)
Protein
Receptor protein-tyrosine kinase
Gene
egfra
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Catalytic activityi
- EC:2.7.10.1ARBA annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- epidermal growth factor-activated receptor activity Source: GO_Central
- epidermal growth factor binding Source: GO_Central
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- blood vessel lumenization Source: ZFIN
- cell differentiation Source: GO_Central
- multicellular organism development Source: GO_Central
- negative regulation of apoptotic process Source: GO_Central
- positive regulation of cell population proliferation Source: GO_Central
- positive regulation of epithelial cell proliferation Source: GO_Central
- positive regulation of kinase activity Source: GO_Central
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, ReceptorImportedARBA annotation, Transferase, Tyrosine-protein kinaseARBA annotation |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-030918-1, egfra |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- basal plasma membrane Source: GO_Central
- integral component of plasma membrane Source: GO_Central
Other locations
- receptor complex Source: GO_Central
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_5015090484 | 21 – 389 | Receptor protein-tyrosine kinaseSequence analysisAdd BLAST | 369 |
Keywords - PTMi
PhosphoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000013847, Expressed in swim bladder and 25 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 54 – 165 | Recep_L_domainInterPro annotationAdd BLAST | 112 | |
Domaini | 183 – 334 | Furin-likeInterPro annotationAdd BLAST | 152 |
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155450 |
Family and domain databases
CDDi | cd00064, FU, 1 hit |
Gene3Di | 3.80.20.20, 1 hit |
InterProi | View protein in InterPro IPR006211, Furin-like_Cys-rich_dom IPR006212, Furin_repeat IPR009030, Growth_fac_rcpt_cys_sf IPR000494, Rcpt_L-dom IPR036941, Rcpt_L-dom_sf |
Pfami | View protein in Pfam PF00757, Furin-like, 1 hit PF01030, Recep_L_domain, 1 hit |
SMARTi | View protein in SMART SM00261, FU, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
F1RA48-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGPTEIGLF FTLLLSGSFC ATPEKKVCQG ANNKLTLLGT VEDHYQVLLR
60 70 80 90 100
MYRNCTVVLE NLEITHITEK YDLSFLKSIQ EVGGYVLIAV NTVSKIPLEN
110 120 130 140 150
LRIIRGHSLY EDKFALAVLV NYNNSIEQGV KELPLTSLTE ILKGGVRFNM
160 170 180 190 200
NNHLCNVGTI EWADILNMKS LPTIVSHNIS YGKNCGKCDP SCFNGSCWGT
210 220 230 240 250
GPDKCQRMTK VICAEQCSGR CKGPRPIDCC NEHCAAGCTG PRPTDCLACK
260 270 280 290 300
DFQDEGTCKD ACPRLMLYDP NTHQLAPNPY GKYSFGATCI KTCPHNYVVT
310 320 330 340 350
DHGACVRTCS PGTYEVDEGG VRKCKRCEGL CPKGTTQTDF CFISSLTNVM
360 370 380
RLLLVVLVVY RVSAGSKKVL KVHKSGCRNL RPLRSIKKS
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4IFV9 | A0A0R4IFV9_DANRE | Receptor protein-tyrosine kinase | egfra | 1,191 | Annotation score: | ||
F1R671 | F1R671_DANRE | Receptor protein-tyrosine kinase | egfra | 760 | Annotation score: | ||
F1Q7X2 | F1Q7X2_DANRE | Receptor protein-tyrosine kinase | egfra | 625 | Annotation score: | ||
F1RBY7 | F1RBY7_DANRE | Receptor protein-tyrosine kinase | egfra | 503 | Annotation score: | ||
F1QU74 | F1QU74_DANRE | Epidermal growth factor receptor a ... | egfra | 243 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CABZ01112600 Genomic DNA No translation available. CABZ01112601 Genomic DNA No translation available. CABZ01112602 Genomic DNA No translation available. CR788232 Genomic DNA No translation available. CU929423 Genomic DNA No translation available. FP245481 Genomic DNA No translation available. KT023304 mRNA Translation: AKS25896.1 |
Genome annotation databases
Ensembli | ENSDART00000128514; ENSDARP00000104998; ENSDARG00000013847 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CABZ01112600 Genomic DNA No translation available. CABZ01112601 Genomic DNA No translation available. CABZ01112602 Genomic DNA No translation available. CR788232 Genomic DNA No translation available. CU929423 Genomic DNA No translation available. FP245481 Genomic DNA No translation available. KT023304 mRNA Translation: AKS25896.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSDART00000128514; ENSDARP00000104998; ENSDARG00000013847 |
Organism-specific databases
ZFINi | ZDB-GENE-030918-1, egfra |
Phylogenomic databases
GeneTreei | ENSGT00940000155450 |
Miscellaneous databases
ChiTaRSi | egfra, zebrafish |
Gene expression databases
Bgeei | ENSDARG00000013847, Expressed in swim bladder and 25 other tissues |
Family and domain databases
CDDi | cd00064, FU, 1 hit |
Gene3Di | 3.80.20.20, 1 hit |
InterProi | View protein in InterPro IPR006211, Furin-like_Cys-rich_dom IPR006212, Furin_repeat IPR009030, Growth_fac_rcpt_cys_sf IPR000494, Rcpt_L-dom IPR036941, Rcpt_L-dom_sf |
Pfami | View protein in Pfam PF00757, Furin-like, 1 hit PF01030, Recep_L_domain, 1 hit |
SMARTi | View protein in SMART SM00261, FU, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1RA48_DANRE | |
Accessioni | F1RA48Primary (citable) accession number: F1RA48 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | May 3, 2011 | |
Last modified: | October 7, 2020 | |
This is version 67 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |