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Entry version 68 (05 Jun 2019)
Sequence version 1 (03 May 2011)
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Protein
Submitted name:

Si:ch211-241e1.3

Gene

si:ch211-241e1.3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Si:ch211-241e1.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:si:ch211-241e1.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-230 si:ch211-241e1.3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi124 ↔ 133PROSITE-ProRule annotation
Disulfide bondi178 ↔ 187PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1R9B8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000022615 Expressed in 12 organ(s), highest expression level in zone of skin

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000119869

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini105 – 151Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini152 – 207Laminin EGF-likeInterPro annotationAdd BLAST56
Domaini1187 – 1345LAM_G_DOMAINInterPro annotationAdd BLAST159

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili237 – 264Sequence analysisAdd BLAST28
Coiled coili306 – 326Sequence analysisAdd BLAST21
Coiled coili348 – 375Sequence analysisAdd BLAST28
Coiled coili381 – 401Sequence analysisAdd BLAST21
Coiled coili441 – 475Sequence analysisAdd BLAST35
Coiled coili480 – 507Sequence analysisAdd BLAST28
Coiled coili522 – 545Sequence analysisAdd BLAST24
Coiled coili552 – 579Sequence analysisAdd BLAST28
Coiled coili596 – 623Sequence analysisAdd BLAST28
Coiled coili644 – 695Sequence analysisAdd BLAST52

Keywords - Domaini

Coiled coilSequence analysis, Laminin EGF-like domainPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1836 Eukaryota
ENOG410XRDC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155638

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR009254 Laminin_aI
IPR010307 Laminin_dom_II
IPR002049 Laminin_EGF
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00053 Laminin_EGF, 2 hits
PF00054 Laminin_G_1, 1 hit
PF02210 Laminin_G_2, 1 hit
PF06008 Laminin_I, 1 hit
PF06009 Laminin_II, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00180 EGF_Lam, 2 hits
SM00282 LamG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 2 hits
PS50025 LAM_G_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

F1R9B8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XHLFHSNKQR GMSESMAWRT AVLRALISGT LFLLVSAGPR PEHRSPQREE
60 70 80 90 100
AEWIQRAQLN DAQRVQFPSL HDTQQVQIPT LEDGQRCPAG HYLDRSGLFP
110 120 130 140 150
RCVPCSCNGH SNECEENTGR CLNCADNTAG QRCELCKEGF YWSEARRKCT
160 170 180 190 200
ACPCPLGNQD NNFAVGCTET QSRIQCVCKT GHAGERCERC ASGYYGDPLV
210 220 230 240 250
YGGGCRPCRC AGNLCDSKTG ACRNSLELQD TNTEEQCEEC DNCAQTLLND
260 270 280 290 300
LEKLEMELRR IKGQADFDSL RPSSKALLKQ LEDAITATKN LVNTFSFAVN
310 320 330 340 350
SQMPKIVQLE QDVINLADDM DSLKEEVRKR SGDSQKALAN AENSHQRAKD
360 370 380 390 400
LDTETQNLLT KIRELLKQLM DAKSDGSSLP SADLAKLLEK SENMVKDMEK
410 420 430 440 450
RSFTTQKDAA KKEQAEANKF LEDVKNIVKQ CDQNEEASKR VDGLLSNYET
460 470 480 490 500
KLKELEDLLK QAENMVKKAK NLNDVNAQGL KDILKRVNDL QRERDVVRDQ
510 520 530 540 550
IVLATDQLKD TQDLLKMFND GKTEYEQLAA QLNGAKTDLK KKLQTVSQAA
560 570 580 590 600
AKEKLVQQAE EHAENMYKLA KELQDAVQNV SGRSGVQDAL SGIEAYKNIT
610 620 630 640 650
DAVNAAEEAA KKAKEAADKA LNDVSQGDLI NRAQDLKTNG SNLLKTAKNT
660 670 680 690 700
AKDLKGATKD LTEQKNRLQD AEKKKKALEE ELLKIQDGLK GIQRDDIAKI
710 720 730 740 750
IDAAKKTAAA ANRSTSDTMD QLNDIKAEVK KISITPTVSN MDNVLNNVDM
760 770 780 790 800
TVKNVSGSIP SLLDKIDELN NQINYGNNVS DNINKIKELI EQARDAANRV
810 820 830 840 850
VVPMKFTGVG HVELRPPADL ADMRAFTALS LSLQRPEKPP ARGDDAVVQQ
860 870 880 890 900
DEDDLFVMYL GKKNASGDYI GMVLRKNVLH FIYKLNGREY DIEAYNITES
910 920 930 940 950
SSDLSFFDKI DLYRIYQDAE VTYTKQYTSI NPMPPQTKEN KGDLTRNLLD
960 970 980 990 1000
LQPDDVVFYV GGYPDNFTPP ASLNYGKYKG CIEFSTFNEK FLSLYNFKNA
1010 1020 1030 1040 1050
VNINLETPCK RQIPLKSTES DYFEGSGYAK VLLERFPSNL QLVQRVETRA
1060 1070 1080 1090 1100
KDALLLYLGD KDDDFYYSAS LEGGYLVLRG QEKDTILEPI RSNEQPVLSP
1110 1120 1130 1140 1150
GIDVRLILVN RKNLRVIIGT TEVKRDVNIP RKFLYYYIGG IPSILRERYN
1160 1170 1180 1190 1200
ITVPALKACV KNILVSNVAP FIEEKVGIGR GCSDELLMVR KAEFGSGSAL
1210 1220 1230 1240 1250
EKLREDFKLD DVNLSMGFRS TKSDGILMEN QKNNNFIKLS LENGFVVLYF
1260 1270 1280 1290 1300
GGLIYTSTKQ YQDGEWHYLT AVAKGQSVEL RVDEEDVGQR LTGIFREQYS
1310 1320 1330 1340
SNVVLGKNTY EGCVSNLYLR RPGSPYRAED LSVYSSSGDV RLSTCSM
Length:1,347
Mass (Da):150,798
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i75E3B93241DA54CB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL935300 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000140540; ENSDARP00000119869; ENSDARG00000022615

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935300 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000119869

Proteomic databases

PaxDbiF1R9B8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000140540; ENSDARP00000119869; ENSDARG00000022615

Organism-specific databases

ZFINiZDB-GENE-030131-230 si:ch211-241e1.3

Phylogenomic databases

eggNOGiKOG1836 Eukaryota
ENOG410XRDC LUCA
GeneTreeiENSGT00940000155638

Gene expression databases

BgeeiENSDARG00000022615 Expressed in 12 organ(s), highest expression level in zone of skin

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR009254 Laminin_aI
IPR010307 Laminin_dom_II
IPR002049 Laminin_EGF
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00053 Laminin_EGF, 2 hits
PF00054 Laminin_G_1, 1 hit
PF02210 Laminin_G_2, 1 hit
PF06008 Laminin_I, 1 hit
PF06009 Laminin_II, 1 hit
SMARTiView protein in SMART
SM00180 EGF_Lam, 2 hits
SM00282 LamG, 2 hits
SUPFAMiSSF49899 SSF49899, 3 hits
PROSITEiView protein in PROSITE
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 2 hits
PS50025 LAM_G_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1R9B8_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1R9B8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: June 5, 2019
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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