UniProtKB - F1R8Q9 (F1R8Q9_DANRE)
Protein
Submitted name:
Pim proto-oncogene, serine/threonine kinase,-related 64
Gene
pimr64
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 114 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- protein serine/threonine kinase activity Source: GO_Central
GO - Biological processi
- negative regulation of apoptotic process Source: GO_Central
- protein autophosphorylation Source: GO_Central
- regulation of mitotic cell cycle Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Pim proto-oncogene, serine/threonine kinase,-related 64Imported |
Gene namesi | Name:pimr64Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-091113-46, pimr64 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000055551, Expressed in testis and 13 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 85 – 363 | Protein kinaseInterPro annotationAdd BLAST | 279 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 84 | DisorderedSequence analysisAdd BLAST | 84 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 14 – 30 | PolarSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the protein kinase superfamily.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00950000182996 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
F1R8Q9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALVGESRGR SRSRSAAFPE TQTAALDTDT QEATDELPGY LAPLSSQLAD
60 70 80 90 100
SVSTDQKKRK RQIDSQQTRS TSSRRSAKRS RRDEYVKGPL LGRGGFGSVF
110 120 130 140 150
AGIRRSDGLP VAIKYVSKDR TCETLRVDGQ GRLPLEVALM IRVTSAPACP
160 170 180 190 200
SVLQLLDWFD RPRRYVLILE RPAPCQDLQS FCEENGCLDE RLAKRVLVQL
210 220 230 240 250
IAALKHCESR GVLHRDVKPE NLLISTETQD IKLLDFGCGD QLKSSAYRYF
260 270 280 290 300
AGTPAYAPPE WFRRHRYHAA PATVWSVGVT LFNILCDRFP FRGARRVTSR
310 320 330 340 350
SRLLFPRQLS TGLEKGSCTL AAPSYRAEQT LYSSETPPEQ LQDRRSAIIP
360
LMRRDADAHT PAD
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9QER9 | E9QER9_DANRE | Non-specific serine/threonine prote... | pimr64 | 311 | Annotation score: | ||
E9QEU8 | E9QEU8_DANRE | Pim proto-oncogene, serine/threonin... | pimr64 | 311 | Annotation score: | ||
X1WGR0 | X1WGR0_DANRE | Pim proto-oncogene, serine/threonin... | pimr64 | 353 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CT573382 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000077922; ENSDARP00000072388; ENSDARG00000113632 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CT573382 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSDART00000077922; ENSDARP00000072388; ENSDARG00000113632 |
Organism-specific databases
ZFINi | ZDB-GENE-091113-46, pimr64 |
Phylogenomic databases
GeneTreei | ENSGT00950000182996 |
Gene expression databases
Bgeei | ENSDARG00000055551, Expressed in testis and 13 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1R8Q9_DANRE | |
Accessioni | F1R8Q9Primary (citable) accession number: F1R8Q9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | June 20, 2018 | |
Last modified: | April 7, 2021 | |
This is version 56 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |