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Entry version 74 (07 Apr 2021)
Sequence version 2 (09 Jan 2013)
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Protein
Submitted name:

Si:ch211-213a13.2

Gene

si:ch211-213a13.2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Si:ch211-213a13.2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:si:ch211-213a13.2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-050208-551, si:ch211-213a13.2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1R805

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000074546, Expressed in muscle organ and 18 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000119526

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini261 – 395NACHTInterPro annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 51DisorderedSequence analysisAdd BLAST51

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4308, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01020000230445

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002274_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1R805

TreeFam database of animal gene trees

More...
TreeFami
TF352120

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR006553, Leu-rich_rpt_Cys-con_subtyp
IPR032675, LRR_dom_sf
IPR029495, NACHT-assoc
IPR007111, NACHT_NTPase
IPR041267, NLRP_HD2
IPR041075, NOD2_WH
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14484, FISNA, 1 hit
PF13516, LRR_6, 9 hits
PF05729, NACHT, 1 hit
PF17776, NLRC4_HD2, 1 hit
PF17779, NOD2_WH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01288, FISNA, 1 hit
SM00367, LRR_CC, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 14 hits
PS50837, NACHT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

F1R805-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEMEGASPK MSLPEKHRMR SGSHAPSSVS MKSDWSMEKP PDLTSEGKPA
60 70 80 90 100
STTSFLSLKS DWSMEKPPDL TCKRKLMSTK RLLSETQDFQ AHKNHKNFTD
110 120 130 140 150
NLQEIFKNLE SQIISFLTNE FEMFKKILLR VNTNNFVKDF NENRCSIREA
160 170 180 190 200
ALDLTLYFLR EMKQDEAADT LEDELFFIHQ LKCGLQKKYQ CVFEGIAQQG
210 220 230 240 250
DSTLLKNIYT DLYITQGGSE QVNTKHEVRQ IEVTSRHHEA QEIQVECRHL
260 270 280 290 300
FEASEQDKQI RTVLTKGVAG IGKSVSVQKF VLDWAEGKEN QEISFIFPLP
310 320 330 340 350
FREMNLKEKE TLSLMELITQ FYPETKGLNL TRRNRFKVLF ILDGLDECRL
360 370 380 390 400
PLNFAGNETC CDVSSPVSLD VLLTNLIKGN LLPSALIWIT SRPAAASKIP
410 420 430 440 450
PDCIDRVTEV RGFNDEQKVE YFRKRLTDEN QAKEIIDHVK QSKSLFIMCH
460 470 480 490 500
IPVFCWISAT VLQNFLQEKR NNDVKHNQAD SKTLQESNTE DTPKTLTQMY
510 520 530 540 550
THFLRFQIQQ SRRKYDGENT PDVSWDKDAI LSLGKLAFQQ LLNSNLIFYD
560 570 580 590 600
TDLEACGIDV YKASVYSGMC TQIFKKETGI VLGTMYCFVH LSVQEFIAAL
610 620 630 640 650
YAHLILDINK KSVFDQDSRN RNESMIDLLK TAVDKALESD NGHLDLFLRF
660 670 680 690 700
LLGLSLQSNR RLLRGLFAQH DHNNKWNIWS IWKIFQYFFR TADQQQDHND
710 720 730 740 750
LSKEEIVQYL KQKFEANLSP ERSINLFYCL NELNDQTLVK EIQTRLSKGS
760 770 780 790 800
LSSADLSPAQ WSALAFVLLT SEEEMEEFEL QKFKKSDECL IRLSAVIKTS
810 820 830 840 850
KRALLSKCNL TEESCSALAS VLRSDSSSLK DLDLSNNNLQ DSGVKLLSDG
860 870 880 890 900
LKDNCKLEKL GLSDCSISEE GYKALASALR SNPSHLIELD LRGNDPGPSG
910 920 930 940 950
VKELTDALLD TKCKAKLRFL SSAADEFCQF VTGIMGKNPL LLKELNLSDR
960 970 980 990 1000
ELGDTRVNQL SDLLQDKHCQ INTLMLKNNR ITAEGCADLM SAFNSNPSHL
1010 1020 1030 1040 1050
TELNLSVNEL GDLGVEKICP LLENTLCRLE KLNLSDCSIT GQSYETLASV
1060 1070 1080 1090 1100
LRSNLYLKEL DLRGNDPGKS GVKKFIDFLQ EGSCKLQIIR FLKSPDAEEA
1110 1120 1130 1140 1150
CEYLTKDLVI NPLLLTELDL SKVKLGHLDG EKFSAFLMDS HNKVEKIKLN
1160 1170 1180 1190 1200
NCKLTEKSCS VLAAVLSSKT ILKEMNLNNS RLLDSGVRKI CEGLKNPVCE
1210 1220 1230 1240 1250
LKILKLLSPA ADEACSFVAV HVGENPLLLK ELNLSNYELG DPRVNQLSAL
1260 1270 1280 1290 1300
LQDKHCKLNT LMLSNCGLTE ESCSALASVL RSDSCSLKDL DLSNNNLQNS
1310 1320 1330 1340 1350
GVKRLSDGLK DNCKLEKLRL SDCSISEGGY KALASALRSN LSHLIELDLR
1360 1370 1380 1390 1400
GNDPGQSGVK ELTDLLQDPH CTLKTLRFLS SAVEEVCKHL SDVLTGDPLI
1410 1420 1430 1440 1450
LKELNLGGCK IEDKVSYLAT LLQDKHCQIS TLVLNNTSIT EEGCANLTSA
1460 1470 1480 1490 1500
ITLNPSHLRE LNLSDNKLGD SAVKNLSDLL IKTQFKLEKL HLSNCSITEE
1510 1520 1530 1540 1550
QCVILTSALK SNPSHLRELN LSVNEMGDSA VKNLRDFLMK PQCNLEKLLL
1560 1570 1580 1590 1600
RQCSITEKQC EILTSALKSN PSHLRELDLS RNEINNTGVN LLSEVLKDSH
1610 1620 1630 1640 1650
CKLERLSLIE CGITDVSSFA HNLMNTETLK ELDLRNNSIL ISRRKLLYVL
1660 1670
SDSNCKLSLD KGNLHQRFAE LFFDNQ
Length:1,676
Mass (Da):188,900
Last modified:January 9, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i18A002BE7CBF8CE5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QLB9F1QLB9_DANRE
Si:ch211-213a13.2
si:ch211-213a13.2
2,849Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8RJB7A0A2R8RJB7_DANRE
Si:ch211-213a13.2
si:ch211-213a13.2
315Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SU76A0A0N4SU76_DANRE
Si:ch211-213a13.2
si:ch211-213a13.2
624Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Q135A0A2R8Q135_DANRE
Si:ch211-213a13.2
si:ch211-213a13.2
299Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Q8T4A0A2R8Q8T4_DANRE
Si:ch211-213a13.2
si:ch211-213a13.2
407Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Q9Z6A0A2R8Q9Z6_DANRE
Si:ch211-213a13.2
si:ch211-213a13.2
682Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Q2Q7A0A2R8Q2Q7_DANRE
Si:ch211-213a13.2
si:ch211-213a13.2
362Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Q338A0A2R8Q338_DANRE
Si:ch211-213a13.2
si:ch211-213a13.2
234Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX248395 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000133993; ENSDARP00000119526; ENSDARG00000074546

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248395 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000119526

Proteomic databases

PaxDbiF1R805

Genome annotation databases

EnsembliENSDART00000133993; ENSDARP00000119526; ENSDARG00000074546

Organism-specific databases

ZFINiZDB-GENE-050208-551, si:ch211-213a13.2

Phylogenomic databases

eggNOGiKOG4308, Eukaryota
GeneTreeiENSGT01020000230445
HOGENOMiCLU_002274_3_0_1
InParanoidiF1R805
TreeFamiTF352120

Gene expression databases

BgeeiENSDARG00000074546, Expressed in muscle organ and 18 other tissues

Family and domain databases

Gene3Di3.80.10.10, 6 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR006553, Leu-rich_rpt_Cys-con_subtyp
IPR032675, LRR_dom_sf
IPR029495, NACHT-assoc
IPR007111, NACHT_NTPase
IPR041267, NLRP_HD2
IPR041075, NOD2_WH
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF14484, FISNA, 1 hit
PF13516, LRR_6, 9 hits
PF05729, NACHT, 1 hit
PF17776, NLRC4_HD2, 1 hit
PF17779, NOD2_WH, 1 hit
SMARTiView protein in SMART
SM01288, FISNA, 1 hit
SM00367, LRR_CC, 8 hits
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51450, LRR, 14 hits
PS50837, NACHT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1R805_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1R805
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: January 9, 2013
Last modified: April 7, 2021
This is version 74 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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