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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene

cacna1fa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.UniRule annotation

GO - Molecular functioni

  • high voltage-gated calcium channel activity Source: GO_Central
  • voltage-gated calcium channel activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:cacna1faImported
Synonyms:si:ch73-289n4.1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-091204-7 cacna1fa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei85 – 104HelicalSequence analysisAdd BLAST20
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Transmembranei156 – 175HelicalSequence analysisAdd BLAST20
Transmembranei230 – 253HelicalSequence analysisAdd BLAST24
Transmembranei309 – 330HelicalSequence analysisAdd BLAST22
Transmembranei342 – 364HelicalSequence analysisAdd BLAST23
Transmembranei489 – 507HelicalSequence analysisAdd BLAST19
Transmembranei527 – 551HelicalSequence analysisAdd BLAST25
Transmembranei619 – 638HelicalSequence analysisAdd BLAST20
Transmembranei688 – 710HelicalSequence analysisAdd BLAST23
Transmembranei820 – 838HelicalSequence analysisAdd BLAST19
Transmembranei877 – 904HelicalSequence analysisAdd BLAST28
Transmembranei925 – 958HelicalSequence analysisAdd BLAST34
Transmembranei1008 – 1029HelicalSequence analysisAdd BLAST22
Transmembranei1050 – 1076HelicalSequence analysisAdd BLAST27
Transmembranei1130 – 1148HelicalSequence analysisAdd BLAST19
Transmembranei1160 – 1180HelicalSequence analysisAdd BLAST21
Transmembranei1255 – 1273HelicalSequence analysisAdd BLAST19
Transmembranei1347 – 1370HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSDARG00000010933 Expressed in 7 organ(s), highest expression level in head

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1504 – 1538Ca_chan_IQInterPro annotationAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1560 – 1580Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
InParanoidiF1R736
OMAiHHYFIDP
OrthoDBiEOG091G0TKO
TreeFamiTF312805

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR031688 CAC1F_C
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR030157 VDCC_L_a1F
IPR005446 VDCC_L_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF184 PTHR10037:SF184, 1 hit
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16885 CAC1F_C, 2 hits
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
PR01630 LVDCCALPHA1
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

F1R736-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SNEEEEGGGE AEEEEEEGGE GGGGGDEETL MSTTSSTATQ KKKSQHVKKQ
60 70 80 90 100
VQGSNQVQRA PRALYCLKLN NPIRRAALHL VEWKPFDIFI LLAIFANCVA
110 120 130 140 150
LGVSKPFPED DSNATNHDLE QVEYVFLIIF TIETFLKILA YGLVMHPSSY
160 170 180 190 200
IRNGWNLLDF VIVIVGLFSV VLETVTHKSG ETTSHTPGKP GGLDVKALRA
210 220 230 240 250
FRVLRPLRLV SGVPSLQIVL NSIMKAMVPL LHISLLVLFV IIIYAIIGLE
260 270 280 290 300
LFIGRMHRTC FYIGTDNYAD DDPLPCAFAG HGRQCYVNGS ECRGKWEGPN
310 320 330 340 350
GGITNFDNFF FAMLTVFQCI TMEGWTDVLY WMNDAIGFEL PWVYFVSLVI
360 370 380 390 400
FGSFFVLNLV LGVLSGEFSK EREKAKARGD FQKLREKQQM EEDLCGYMDW
410 420 430 440 450
ITQAEDIDEF DEDGNRRVTL RDLADKKRGK FGWFSHSNET HGTANQNEPH
460 470 480 490 500
DPFTPSTALY IDPLNIVCRA LRRWNRCIRR NCRTAVKSVT FYWLVLILVF
510 520 530 540 550
LNTALSASEH YNQPEWLTDV QDIANKVLLS LFTVEMLLKM YSLGLQVYFV
560 570 580 590 600
AFFNRFDCFV VCGGILETVL VEMEIMPPLG ISVLRCVRLL RIFKVTRHWT
610 620 630 640 650
ALSNLVASLL NSMKSIASLL LLLFLFLIIF ALLGMQLFGG KFNFDETQTK
660 670 680 690 700
RSTFDSFPQA LLTCFQILTG EDWNVVMYDG IMAYGGPVFP GMIVCLYFVI
710 720 730 740 750
LFICGNYILL NVFLAIAVDN LAGGDGDNKK NDPSGVSRGL GCQLKGTVLI
760 770 780 790 800
ELDCDLINSI PLYFFLSIFP LEEGKIQLNV ADFAPPKEKI LPIPEGSAFF
810 820 830 840 850
CLSKTNPIRV GCHTLIHHHI FTNLILVFII LSSISLAAED PIRAHSFRNN
860 870 880 890 900
VLGYADYAFT SIFTVEILLK VLRQKNIFAV SIFSSDLFFS ISLSSSAISV
910 920 930 940 950
VKILRVLRVL RPLRAINRAK GLKHVVQCVF VAIRTIGNIM IVTTLLQFMF
960 970 980 990 1000
ACIGVQLFKG KFYRCTDEAK NTPEQCKGTF VVYKDGDVSH PMVRERIWLN
1010 1020 1030 1040 1050
SDFNFDNVLM GMMALFTVST FEGWPALLYK AIDANGENHG PIYNYRVEIS
1060 1070 1080 1090 1100
IFFIVYIIII AFFMMNIFVG FVIITFREQG EAEFKNCELD KNQRQCVEYA
1110 1120 1130 1140 1150
LKAQPLKLYI PKNPVQYKFW SIINSTGFEY VMFVLILLNT VTLAVQHYDQ
1160 1170 1180 1190 1200
SKFFSQVMDI LNMVFTGLFT VEMIIKLMAL RLRHYFVDAW NSFDALIVVG
1210 1220 1230 1240 1250
SVVDIVVTEF SSSEDSSRVS ITFFRLFRVM RLVKLLSKGE GIRTLLWTFV
1260 1270 1280 1290 1300
KSLQALPYVA LLIAMIFFIY AVIGMQTFGK IAMQDHTQIN RNNNFQTFPQ
1310 1320 1330 1340 1350
AVLLLFRCAT GEAWQEIMLA SLPGKRCDAE SDFEPGEEFS CGSNIAIVYF
1360 1370 1380 1390 1400
ISFFMLCAFL IINLFVAVIM DNFDYLTRDW SILGPHHLDE FKRIWSEYDP
1410 1420 1430 1440 1450
EAKGRIKHLD VVALLRRIQP PLGFGKLCPH RVACKRLVAM NMPLNADGTV
1460 1470 1480 1490 1500
TFNATLFALV RTALKIKTDG NPDQENEELR IIIKKIWKRT KPKVLDEVIP
1510 1520 1530 1540 1550
PPAEEEVTVG KFYATFLIQD YFRKFRKRKE KVGLEEEGNG NPTALQAGLR
1560 1570 1580 1590 1600
TLQELGPEMR LAMNEDLEEE EEGLDEEQEE DDAHYKVPIT SGFCYVKNPD
1610 1620 1630 1640 1650
DKGFKAYDEN TISILKMFSI RHGYPEDSTI FQGHRDMYDG HSMRHPVYGN
1660 1670 1680 1690 1700
HYGNSYGDGR RTARRRLLPA TPTGRKASFN IQCLRRQGSS DDLPIPGTYH
1710 1720 1730 1740 1750
QNSPPCRAPS WANTGPRRGR LLYAPLILVE EEGAAGAGGV GWYSGPSPYR
1760 1770 1780 1790 1800
AYTTLRVPTQ LSPHYSEKRG SADSLVEAVL ISEGLGLYAK DPKFVAFAKR
1810 1820 1830 1840 1850
EIADACHMTI DEMESAASSE KSQKFMNHTD TGLVYSDEEP IKSHEEEELA

DEMTCVTSF
Length:1,859
Mass (Da):210,345
Last modified:June 20, 2018 - v3
Checksum:i6F5A3F9D42EC7D08
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QGT9F1QGT9_DANRE
Voltage-dependent L-type calcium ch...
cacna1fa si:ch73-289n4.1
659Annotation score:
A0A2R8QID9A0A2R8QID9_DANRE
Voltage-dependent L-type calcium ch...
cacna1fa
1,737Annotation score:
A0A2R8RU84A0A2R8RU84_DANRE
Voltage-dependent L-type calcium ch...
cacna1fa
1,841Annotation score:
A0A2R8Q2C7A0A2R8Q2C7_DANRE
Calcium channel, voltage-dependent,...
cacna1fa
303Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL831748 Genomic DNA No translation available.
BX072561 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSDART00000011078; ENSDARP00000022597; ENSDARG00000112226

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL831748 Genomic DNA No translation available.
BX072561 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000011078; ENSDARP00000022597; ENSDARG00000112226

Organism-specific databases

ZFINiZDB-GENE-091204-7 cacna1fa

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
InParanoidiF1R736
OMAiHHYFIDP
OrthoDBiEOG091G0TKO
TreeFamiTF312805

Gene expression databases

BgeeiENSDARG00000010933 Expressed in 7 organ(s), highest expression level in head

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR031688 CAC1F_C
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR030157 VDCC_L_a1F
IPR005446 VDCC_L_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF184 PTHR10037:SF184, 1 hit
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16885 CAC1F_C, 2 hits
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
PR01630 LVDCCALPHA1
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF1R736_DANRE
AccessioniPrimary (citable) accession number: F1R736
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 20, 2018
Last modified: November 7, 2018
This is version 57 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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